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anti-KDM1A antibody :: Rabbit KDM1A Antibody

Scan QR to view Datasheet Catalog #    MBS8502059
Western blot
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KDM1A, Antibody

★Popular Item★
 Also Known As   

KDM1A Antibody

 Product Synonym Names    KDM1; AOF2; BHC110; KIAA0601; LSD1; KDM1A
 Product Gene Name   

anti-KDM1A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609132
 3D Structure    ModBase 3D Structure for O60341
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    Recombinant protein of human KDM1A
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-KDM1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KDM1A antibody

   Lysine-specific demethylase 1 (LSD1; also known as AOF2 and BHC110) is a nuclear amine oxidase homolog that acts as a histone demethylase and transcription cofactor (1). Gene activation and repression is specifically regulated by the methylation state of distinct histone protein lysine residues. For example, methylation of histone H3 at Lys4 facilitates transcriptional activation by coordinating the recruitment of BPTF, a component of the NURF chromatin remodeling complex, and WDR5, a component of multiple histone methyltransferase complexes (2, 3). In contrast, methylation of histone H3 at Lys9 facilitates transcriptional repression by recruiting HP1 (4, 5). LSD1 is a component of the CoREST transcriptional co-repressor complex that also contains CoREST, CtBP, HDAC1 and HDAC2. As part of this complex, LSD1 demethylates mono-methyl and di-methyl histone H3 at Lys4 through a FAD-dependent oxidation reaction to facilitate neuronal-specific gene repression in non-neuronal cells (1, 6, 7). In contrast, LSD1 associates with androgen receptor in human prostate cells to demethylate mono-methyl and di-methyl histone H3 at Lys9 and facilitate androgen receptor-dependent transcriptional activation (8). Therefore, depending on gene context LSD1 can function as either a transcriptional co-repressor or co-activator. LSD1 activity is inhibited by the amine oxidase inhibitors pargyline, deprenyl, clorgyline and tranylcypromine (8).
 Product Categories/Family for anti-KDM1A antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-KDM1A antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-KDM1A antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Western blot of anti-KDM1A antibody    Western blot analysis of extracts of PC12 celllysate using KDM1A antibody.
anti-KDM1A antibody Western blot image
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NCBI/Uniprot data below describe general gene information for KDM1A. It may not necessarily be applicable to this product.
 NCBI GI #    58761544
 NCBI GeneID    23028
 NCBI Accession #    NP_001009999.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001009999.2 [Other Products]
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 UniProt Primary Accession #    O60341 [Other Products]
 UniProt Secondary Accession #    Q5TH94; Q5TH95; Q86VT7; Q8IXK4; Q8NDP6; Q8TAZ3; Q96AW4; A8MWP9 [Other Products]
 UniProt Related Accession #    O60341 [Other Products]
 Molecular Weight    95kDa
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 NCBI Official Full Name    lysine-specific histone demethylase 1A isoform a
 NCBI Official Synonym Full Names    lysine demethylase 1A
 NCBI Official Symbol    KDM1A [Similar Products]
 NCBI Official Synonym Symbols   
AOF2; CPRF; KDM1; LSD1; BHC110
[Similar Products]
 NCBI Protein Information    lysine-specific histone demethylase 1A
 UniProt Protein Name    Lysine-specific histone demethylase 1A
 UniProt Synonym Protein Names   
BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2
 Protein Family    Lysine-specific histone demethylase
 UniProt Gene Name    KDM1A [Similar Products]
 UniProt Synonym Gene Names    AOF2; KDM1; KIAA0601; LSD1 [Similar Products]
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 NCBI Summary for KDM1A    This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
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 UniProt Comments for KDM1A    Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.
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Product References and Citations for anti-KDM1A antibody

   1. Shi, Y. et al. (2004) Cell 119, 941-953. 2. Wysocka, J. et al. (2006) Nature 442, 86-90. 3. Wysocka, J. et al. (2005) Cell 121, 859-872. 4. Jacobs, S.A. and Khorasanizadeh, S. (2002) Science 295, 2080-2083. 5. Nielsen, P.R. et al. (2002) Nature 416, 103-107. 6. Shi, Y.J. et al. (2005) Mol. Cell 19, 857-864. 7. Lee, M.G. et al. (2005) Nature 437, 432-435. 8. Metzger, E. et al. (2005) Nature 437, 436-439.
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 Research Articles on KDM1A    1. Results show that LSD1 protein level is elevated in prostate tumors (PCa) and correlate with faster tumor growth in xenograft mouse models. Knockdown of LSD1 reduces PCa cell viability, and gene expression data suggest a dual coregulatory role of LSD1 for VDR, acting as a coactivator and corepressor in a locus-specific manner.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-KDM1A antibodyDiseases associated with anti-KDM1A antibody
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >54 publications with KDM1A and Neoplasms
 Breast Neoplasms Antibodies  >14 publications with KDM1A and Breast Neoplasms
 Colorectal Neoplasms Antibodies  >7 publications with KDM1A and Colorectal Neoplasms
 Intestinal Neoplasms Antibodies  >5 publications with KDM1A and Intestinal Neoplasms
 Lymphoma Antibodies  >5 publications with KDM1A and Lymphoma
 Disease Models, Animal Antibodies  >4 publications with KDM1A and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >4 publications with KDM1A and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >4 publications with KDM1A and Neoplasm Invasiveness
 Liver Diseases Antibodies  >3 publications with KDM1A and Liver Diseases
 Inflammation Antibodies  >3 publications with KDM1A and Inflammation
Organs/Tissues associated with anti-KDM1A antibody
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >17 publications with KDM1A and Nerve
 Prostate Antibodies  >11 publications with KDM1A and Prostate
 Brain Antibodies  >9 publications with KDM1A and Brain
 Blood Antibodies  >8 publications with KDM1A and Blood
 Lung Antibodies  >6 publications with KDM1A and Lung
 Heart Antibodies  >4 publications with KDM1A and Heart
 Embryonic Tissue Antibodies  >4 publications with KDM1A and Embryonic Tissue
 Muscle Antibodies  >4 publications with KDM1A and Muscle
 Bone Antibodies  >4 publications with KDM1A and Bone
 Liver Antibodies  >3 publications with KDM1A and Liver
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