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anti-KI67 antibody :: Mouse anti-Human KI67 Antibody

Scan QR to view Datasheet Catalog #    MBS850259
Western Blot (WB)
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KI67, Antibody

★Popular Item★
 Also Known As   

KI67 Antibody

 Product Synonym Names    KIA; Ki-67; MKI67
 Product Gene Name   

anti-KI67 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176741
 3D Structure    ModBase 3D Structure for P46013
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 Isotype    IgG1
 Clone Number    9C12B2
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of Ki167 (aa3118-3256) expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C
 Other Notes    Small volumes of anti-KI67 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KI67 antibody

   Ki67. antigen identified by monoclonal antibody Ki-67. Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.
 Product Categories/Family for anti-KI67 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-KI67 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-KI67 antibody    WB: 1:500-1:2000
ELISA: 1:10000
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 Western Blot (WB) of anti-KI67 antibody    Figure 1. Western blot analysis using Ki67 mouse mAb against truncated Trx-Ki67 recombinant protein(1), truncated Ki67 (aa3118-3256)-His recombinant protein(2) and truncated Ki67 (aa3118-3256)-hIgGFc transfected CHO-K1 cell lysate(3).
anti-KI67 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for KI67. It may not necessarily be applicable to this product.
 NCBI GI #    225543215
 NCBI GeneID    4288
 NCBI Accession #    NP_001139438.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145966.1 [Other Products]
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 UniProt Primary Accession #    P46013 [Other Products]
 UniProt Secondary Accession #    Q5VWH2 [Other Products]
 UniProt Related Accession #    P46013 [Other Products]
 Molecular Weight    319,444 Da
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 NCBI Official Full Name    proliferation marker protein Ki-67 isoform 2
 NCBI Official Synonym Full Names    marker of proliferation Ki-67
 NCBI Official Symbol    MKI67 [Similar Products]
 NCBI Official Synonym Symbols   
KIA; MIB-; MIB-1; PPP1R105
[Similar Products]
 NCBI Protein Information    proliferation marker protein Ki-67
 UniProt Protein Name    Proliferation marker protein Ki-67
 UniProt Synonym Protein Names   
Antigen identified by monoclonal antibody Ki-67
 UniProt Gene Name    MKI67 [Similar Products]
 UniProt Synonym Gene Names    Antigen KI-67Curated; Antigen Ki67Curated [Similar Products]
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 NCBI Summary for KI67    This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
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 UniProt Comments for KI67    Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
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 Research Articles on KI67    1. High Ki-67 expression in localized PCa is a factor of poor prognosis for prostate cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KI67 antibodyDiseases associated with anti-KI67 antibody
 Reference Product  PubMed Publications
 MKI67IP antibody  >8 publications with KI67 and MKI67IP
 CBX3 antibody  >1 publications with KI67 and CBX3
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9254 publications with KI67 and Neoplasms
 Adenocarcinoma Antibodies  >2117 publications with KI67 and Adenocarcinoma
 Breast Neoplasms Antibodies  >1548 publications with KI67 and Breast Neoplasms
 Nervous System Diseases Antibodies  >1433 publications with KI67 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >1044 publications with KI67 and Neoplasm Metastasis
 Carcinoma, Squamous Cell Antibodies  >981 publications with KI67 and Carcinoma, Squamous Cell
 Adenoma Antibodies  >693 publications with KI67 and Adenoma
 Hyperplasia Antibodies  >583 publications with KI67 and Hyperplasia
 Colorectal Neoplasms Antibodies  >581 publications with KI67 and Colorectal Neoplasms
 Neoplasms, Experimental Antibodies  >534 publications with KI67 and Neoplasms, Experimental
Organs/Tissues associated with anti-KI67 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1742 publications with KI67 and Blood
 Brain Antibodies  >1239 publications with KI67 and Brain
 Vascular Antibodies  >1110 publications with KI67 and Vascular
 Lymph Node Antibodies  >1097 publications with KI67 and Lymph Node
 Lymph Antibodies  >1092 publications with KI67 and Lymph
 Skin Antibodies  >869 publications with KI67 and Skin
 Lung Antibodies  >635 publications with KI67 and Lung
 Liver Antibodies  >604 publications with KI67 and Liver
 Muscle Antibodies  >596 publications with KI67 and Muscle
 Bone Antibodies  >523 publications with KI67 and Bone
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