NP_115940.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
kiSS-1 receptor
NCBI Official Synonym Full Names
KISS1 receptor
NCBI Official Synonym Symbols
HH8; CPPB1; GPR54; AXOR12; KISS-1R; HOT7T175 [Similar Products]
NCBI Protein Information
kiSS-1 receptor
UniProt Protein Name
KiSS-1 receptor
UniProt Synonym Protein Names
G-protein coupled receptor 54; G-protein coupled receptor OT7T175; hOT7T175; Hypogonadotropin-1; Kisspeptins receptor; Metastin receptor
UniProt Synonym Gene Names
NCBI Summary for KISS1R
The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008]
UniProt Comments for KISS1R
Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
Research Articles on KISS1R
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Products associated with anti-KISS1R antibody
Pathways associated with anti-KISS1R antibody
Diseases associated with anti-KISS1R antibody
Organs/Tissues associated with anti-KISS1R antibody
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