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IGKC antibody :: Kappa Light Chain Antibody

Scan QR to view Datasheet Catalog #    MBS438431
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $150 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $270 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $285 +1 FREE 8GB USB
0.2 mg (With BSA & Azide at 0.2mg/ml)  /  $360 +1 FREE 8GB USB
0.2 mg (Without BSA & Azide at 1mg/ml)  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kappa Light Chain (IGKC), Antibody

 Also Known As   

Kappa Light Chain (B-Cell Marker) Mouse Monoclonal Antibody

 Product Synonym Names    HCAK1; Ig Kappa Chain C Region; IGKC; Immunoglobulin KM
 Product Gene Name   

IGKC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P01601
 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    KLC709
 Host    Mouse
 Species Reactivity    Human
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 Specificity    This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. It recognizes human Ig kappa light chains of both secreted and cell surface immunoglobulin. It detects also free kappa light chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cell Surface, Cytoplasmic and Secreted
 Immunogen    Recombinant human Ig kappa chain
 Hu-Chromosome Location    2p11.2
 Positive Control    293T, Raji or hPBL cells. Tonsil or Spleen
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of IGKC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for IGKC antibody   

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Formalin

 Application Notes for IGKC antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunohistochemistry (Formalin-fixed) (0.5-1.0ug/ml for 30 min at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of IGKC antibody    Formalin-fixed, paraffin-embedded human Tonsil stained with Kappa Light Chain Monoclonal Antibody (KLC709).
IGKC antibody  Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IGKC. It may not necessarily be applicable to this product.
 NCBI GI #    857434459
 NCBI GeneID    3514
 NCBI Accession #    P01601.2 [Other Products]
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 UniProt Primary Accession #    P01601 [Other Products]
 UniProt Secondary Accession #    A0A0B4J1Z3 [Other Products]
 UniProt Related Accession #    P01834; P04431; P01601 [Other Products]
 Molecular Weight    ~22.5kDa
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 NCBI Official Full Name    Ig kappa chain V-ID region 16
 NCBI Official Synonym Full Names    immunoglobulin kappa constant
 NCBI Official Symbol    IGKC [Similar Products]
 NCBI Official Synonym Symbols   
Km; HCAK1; IGKCD
[Similar Products]
 UniProt Protein Name    Ig kappa chain V-ID region 16
 UniProt Synonym Protein Names   
Ig kappa chain V-I region HK101
 UniProt Gene Name    IGKV1D-16 [Similar Products]
 UniProt Entry Name    KV109_HUMAN
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 UniProt Comments for IGKC    KV109:

Protein type: Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: external side of plasma membrane; extracellular region; extracellular space; plasma membrane

Molecular Function: antigen binding; serine-type endopeptidase activity

Biological Process: B cell receptor signaling pathway; complement activation; complement activation, classical pathway; defense response to bacterium; innate immune response; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of B cell activation; receptor-mediated endocytosis; regulation of immune response; retinal homeostasis

Disease: Immunoglobulin Kappa Light Chain Deficiency
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Product References and Citations for IGKC antibody

   Kiyotaki M et. al. J Immunol. 1987;138(12):4150-8. Nakamura T et. al. Proc Natl Acad Sci U S A. 1992;89(18):8522-6
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 Research Articles on IGKC    1. genetic polymorphism is associated with immunobiology of breast cancer in Japan
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with IGKC antibody Organs/Tissues associated with IGKC antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 CD22 Mediated BCR Regulation Pathway antibodies  CD22 Mediated BCR Regulation Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 FCERI Mediated Ca+2 Mobilization Pathway antibodies  FCERI Mediated Ca+2 Mobilization Pathway Diagram
 FCERI Mediated MAPK Activation Pathway antibodies  FCERI Mediated MAPK Activation Pathway Diagram
 FCERI Mediated NF-kB Activation Pathway antibodies  FCERI Mediated NF-kB Activation Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with IGKC and Blood
 Lung Antibodies  >7 publications with IGKC and Lung
 Vascular Antibodies  >3 publications with IGKC and Vascular
 Muscle Antibodies  >2 publications with IGKC and Muscle
 Eye Antibodies  >2 publications with IGKC and Eye
 Uncharacterized Tissue Antibodies  >2 publications with IGKC and Uncharacterized Tissue
 Skin Antibodies  >1 publications with IGKC and Skin
 Intestine Antibodies  >1 publications with IGKC and Intestine
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