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anti-KRT18 antibody :: anti-Human Keratin 18 Antibody

Scan QR to view Datasheet Catalog #    MBS854124
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Keratin 18 (KRT18), Antibody

 Also Known As   

Keratin 18 Antibody

 Product Synonym Names    Keratin type I cytoskeletal 18; Cytokeratin-18; CK-18 K18
 Product Gene Name   

anti-KRT18 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    148070
 3D Structure    ModBase 3D Structure for P05783
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 Species Reactivity    Human
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 Specificity    Keratin 18 antibody detects endogenous levels of total Keratin 18 protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from human Keratin 18.
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-KRT18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KRT18 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-KRT18 antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:10000
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 Immunohistochemistry (IHC) of anti-KRT18 antibody    Peptide-+ Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Keratin 18 antibody.
anti-KRT18 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-KRT18 antibody    Western blot analysis of extracts from HeLa cells, using Keratin 18 antibody.
anti-KRT18 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-KRT18 antibody    Peptide-+ Immunofluorescence analysis of HeLa cells, using Keratin 18 antibody.
anti-KRT18 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for KRT18. It may not necessarily be applicable to this product.
 NCBI GI #    4557888
 NCBI GeneID    3875
 NCBI Accession #    NP_000215.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000224.2 [Other Products]
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 UniProt Primary Accession #    P05783 [Other Products]
 UniProt Secondary Accession #    Q53G38; Q5U0N8; Q9BW26 [Other Products]
 UniProt Related Accession #    P05783 [Other Products]
 Molecular Weight    48,058 Da
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 NCBI Official Full Name    keratin, type I cytoskeletal 18
 NCBI Official Synonym Full Names    keratin 18
 NCBI Official Symbol    KRT18 [Similar Products]
 NCBI Official Synonym Symbols   
K18; CK-18; CYK18
[Similar Products]
 NCBI Protein Information    keratin, type I cytoskeletal 18
 UniProt Protein Name    Keratin, type I cytoskeletal 18
 UniProt Synonym Protein Names   
Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18
 Protein Family    Keratin
 UniProt Gene Name    KRT18 [Similar Products]
 UniProt Synonym Gene Names    CYK18; CK-18; K18 [Similar Products]
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 NCBI Summary for KRT18    KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KRT18    Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
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Product References and Citations for anti-KRT18 antibody

   Thomas M. Magin, J. Cell Biol., Mar 1998; 140: 1441. Carlos Caulín, J. Cell Biol., Sep 1997; 138: 1379. J Liao, J. Cell Biol., Dec 1995; 131: 1291. Nam-On Ku, J. Clin. Invest., Jan 1997; 99: 19.
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 Research Articles on KRT18    1. results show that the caspase digestion-resistant K18 helps to maintain keratin filament organization and delays apoptosis, thereby resulting in protection from liver injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KRT18 antibodyPathways associated with anti-KRT18 antibody
 Reference Product  PubMed Publications
 KRT8 antibody  >39 publications with KRT18 and KRT8
 CASP3 antibody  >5 publications with KRT18 and CASP3
 KRT5 antibody  >3 publications with KRT18 and KRT5
 EGFR antibody  >3 publications with KRT18 and EGFR
 DNAJB6 antibody  >1 publications with KRT18 and DNAJB6
 CASP7 antibody  >1 publications with KRT18 and CASP7
 CASP6 antibody  >1 publications with KRT18 and CASP6
 Products by Pathway  Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram
Diseases associated with anti-KRT18 antibodyOrgans/Tissues associated with anti-KRT18 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >41 publications with KRT18 and Neoplasms
 Liver Diseases Antibodies  >28 publications with KRT18 and Liver Diseases
 Carcinoma Antibodies  >23 publications with KRT18 and Carcinoma
 Adenocarcinoma Antibodies  >13 publications with KRT18 and Adenocarcinoma
 Breast Neoplasms Antibodies  >12 publications with KRT18 and Breast Neoplasms
 Fibrosis Antibodies  >12 publications with KRT18 and Fibrosis
 Fatty Liver Antibodies  >9 publications with KRT18 and Fatty Liver
 Liver Cirrhosis Antibodies  >8 publications with KRT18 and Liver Cirrhosis
 Neoplasm Metastasis Antibodies  >8 publications with KRT18 and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >7 publications with KRT18 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >34 publications with KRT18 and Liver
 Blood Antibodies  >18 publications with KRT18 and Blood
 Eye Antibodies  >6 publications with KRT18 and Eye
 Muscle Antibodies  >6 publications with KRT18 and Muscle
 Kidney Antibodies  >6 publications with KRT18 and Kidney
 Prostate Antibodies  >5 publications with KRT18 and Prostate
 Vascular Antibodies  >4 publications with KRT18 and Vascular
 Lymph Antibodies  >4 publications with KRT18 and Lymph
 Lymph Node Antibodies  >4 publications with KRT18 and Lymph Node
 Bladder Antibodies  >4 publications with KRT18 and Bladder
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