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anti-Kv4.2/KCND2 antibody :: Kv4.2/KCND2 Antibody

Scan QR to view Datasheet Catalog #    MBS859585
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kv4.2/KCND2, Antibody

★Popular Item★
 Also Known As   

Kv4.2/KCND2 (Phospho-Ser616) Antibody

 Product Synonym Names    KCND2; KIAA1044; Potassium channel Kv4.2; Potassium voltage-gated channel subfamily D member 2
 Product Gene Name   

anti-Kv4.2/KCND2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605410
 3D Structure    ModBase 3D Structure for Q9NZV8
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    Kv4.2/KCND2 (Phospho-Ser616) antibody detects endogenous levels of Kv4.2/KCND2 only when phosphorylated at serine 616.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human Kv4.2/KCND2 around the phosphorylation site of serine 616 (P-E-SP-P-E).
 All Sites    Human: Ser616
Mouse: Ser616
Rat: Ser616
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-Kv4.2/KCND2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Kv4.2/KCND2 purchase    Maintenance of PM potassium gradient is fundamental for cell survival. Both inward and outward ion rectifying voltage gated potassium channels are known but distinguishing different subtypes specifically is the job of MyBiosource's Kv4 2 KCND phospho S616 (subfamily member 2) polyclonal antibody product. Generated by rabbit immunizations and affinity isolated , this anti KCND2 antibody will quickly become a favorite. With a broad species reactivity profile, human mouse rat, this product performs equally well in Western blot or IHC research with used with any anti rabbit IgG ALEXA fluorâ® or AMP secondary antibodies . When paired with a nonPhospho Kv4 2 antibody, signaling networks, important in cell biology, may be deduced. Similar experiments with related gene products - potassium voltage gated channel protein - are possible with other ion channel isolated antibody pairs. Advice on such custom uses for related subfamily potassium channel antibody visit our Technical service website.
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 Product Categories/Family for anti-Kv4.2/KCND2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-Kv4.2/KCND2 antibody   

Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-Kv4.2/KCND2 antibody    IHC: 1:50-1:100
ELISA: 1:5000
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 Immunohistochemistry (IHC) of anti-Kv4.2/KCND2 antibody    P-peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv4.2/KCND2 (Phospho-Ser616) antibody.
anti-Kv4.2/KCND2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for Kv4.2/KCND2. It may not necessarily be applicable to this product.
 NCBI GI #    9789987
 NCBI GeneID    3751
 NCBI Accession #    NP_036413.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012281.2 [Other Products]
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 UniProt Primary Accession #    Q9NZV8 [Other Products]
 UniProt Secondary Accession #    O95012; O95021; Q2TBD3; Q9UBY7; Q9UN98; Q9UNH9 [Other Products]
 UniProt Related Accession #    Q9NZV8 [Other Products]
 Molecular Weight    70,537 Da
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 NCBI Official Full Name    potassium voltage-gated channel subfamily D member 2
 NCBI Official Synonym Full Names    potassium voltage-gated channel subfamily D member 2
 NCBI Official Symbol    KCND2 [Similar Products]
 NCBI Official Synonym Symbols   
RK5; KV4.2
[Similar Products]
 NCBI Protein Information    potassium voltage-gated channel subfamily D member 2
 UniProt Protein Name    Potassium voltage-gated channel subfamily D member 2
 UniProt Synonym Protein Names   
Voltage-gated potassium channel subunit Kv4.2
 UniProt Gene Name    KCND2 [Similar Products]
 UniProt Synonym Gene Names    KIAA1044 [Similar Products]
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 NCBI Summary for Kv4.2/KCND2    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Kv4.2/KCND2    Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity ().
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Product References and Citations for anti-Kv4.2/KCND2 antibody

   Kong W., Am. J. Physiol. 275:H1963-H1970(1998). Kikuno R., DNA Res. 6:197-205(1999). Zhu X.-R., Recept. Channels 6:387-400(1999).
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 Research Articles on Kv4.2/KCND2    1. Our results do not support the notion that accessory KChIP2 binding is a prerequisite for dendritic trafficking and functional surface expression of Kv4.2 channels, however, accessory KChIP2 binding may play a potential role in Kv4.2 modulation during intrinsic plasticity processes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Kv4.2/KCND2 antibodyPathways associated with anti-Kv4.2/KCND2 antibody
 Reference Product  PubMed Publications
 KCNIP2 antibody  >16 publications with Kv4.2/KCND2 and KCNIP2
 KCNIP1 antibody  >11 publications with Kv4.2/KCND2 and KCNIP1
 KCNIP4 antibody  >4 publications with Kv4.2/KCND2 and KCNIP4
 KCNH2 antibody  >2 publications with Kv4.2/KCND2 and KCNH2
 IRX5 antibody  >2 publications with Kv4.2/KCND2 and IRX5
 KCNC1 antibody  >1 publications with Kv4.2/KCND2 and KCNC1
 KCNAB2 antibody  >1 publications with Kv4.2/KCND2 and KCNAB2
 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram
Diseases associated with anti-Kv4.2/KCND2 antibodyOrgans/Tissues associated with anti-Kv4.2/KCND2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >22 publications with Kv4.2/KCND2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >21 publications with Kv4.2/KCND2 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >13 publications with Kv4.2/KCND2 and Arrhythmias, Cardiac
 Hypertrophy Antibodies  >10 publications with Kv4.2/KCND2 and Hypertrophy
 Disease Models, Animal Antibodies  >9 publications with Kv4.2/KCND2 and Disease Models, Animal
 Nervous System Diseases Antibodies  >8 publications with Kv4.2/KCND2 and Nervous System Diseases
 Heart Failure Antibodies  >5 publications with Kv4.2/KCND2 and Heart Failure
 Cardiomegaly Antibodies  >5 publications with Kv4.2/KCND2 and Cardiomegaly
 Hypertension Antibodies  >5 publications with Kv4.2/KCND2 and Hypertension
 Seizures Antibodies  >4 publications with Kv4.2/KCND2 and Seizures
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >44 publications with Kv4.2/KCND2 and Brain
 Kidney Antibodies  >11 publications with Kv4.2/KCND2 and Kidney
 Embryonic Tissue Antibodies  >7 publications with Kv4.2/KCND2 and Embryonic Tissue
 Ovary Antibodies  >4 publications with Kv4.2/KCND2 and Ovary
 Vascular Antibodies  >3 publications with Kv4.2/KCND2 and Vascular
 Connective Tissue Antibodies  >1 publications with Kv4.2/KCND2 and Connective Tissue
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