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anti-LAMA5 antibody :: Rabbit LAMA5 Antibody

Scan QR to view Datasheet Catalog #    MBS002764
Immunohistochemistry
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LAMA5, Antibody

 Also Known As   

Rabbit LAMA5 Antibody

 Product Gene Name   

anti-LAMA5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (60884121..60942368, complement). Location: 20q13.2-q13.3
 OMIM    601033
 3D Structure    ModBase 3D Structure for O15230
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 Host    Rabbit
 Species Reactivity    Human (Identities = 100%, Positives = 100%)
Mouse (Identities = 92%, Positives = 100%)
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 Specificity    LAMA5 antibody detects endogenous levels of total LAMA5 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human LAMA5.
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 Preparation and Storage    Store at -20 deg C/ 1 year
 Other Notes    Small volumes of anti-LAMA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LAMA5 antibody   

Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-LAMA5 antibody    IHC: 1:50~1:100
ELISA: 1:20000
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 Immunohistochemistry of anti-LAMA5 antibody    anti-LAMA5 antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for LAMA5. It may not necessarily be applicable to this product.
 NCBI GI #    21264602
 NCBI GeneID    3911
 NCBI Accession #    NP_005551.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005560.3 [Other Products]
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 UniProt Primary Accession #    O15230 [Other Products]
 UniProt Secondary Accession #    Q8TDF8; Q8WZA7; Q9H1P1 [Other Products]
 UniProt Related Accession #    O15230 [Other Products]
 Molecular Weight    399,737 Da
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 NCBI Official Full Name    laminin subunit alpha-5
 NCBI Official Synonym Full Names    laminin, alpha 5
 NCBI Official Symbol    LAMA5 [Similar Products]
 NCBI Protein Information    laminin subunit alpha-5; laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha
 UniProt Protein Name    Laminin subunit alpha-5
 UniProt Synonym Protein Names   
Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha
 Protein Family    Laminin
 UniProt Gene Name    LAMA5 [Similar Products]
 UniProt Synonym Gene Names    KIAA0533; KIAA1907 [Similar Products]
 UniProt Entry Name    LAMA5_HUMAN
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 NCBI Summary for LAMA5    Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LAMA5    LAMA5: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q13.2-q13.3

Cellular Component: extracellular matrix; extracellular space; laminin-5 complex; laminin-1 complex; laminin-10 complex; extracellular region; basement membrane; basal lamina; nucleus

Molecular Function: integrin binding; structural molecule activity

Biological Process: integrin-mediated signaling pathway; regulation of cell adhesion; focal adhesion formation; endothelial cell differentiation; extracellular matrix organization and biogenesis; muscle development; cell migration; regulation of embryonic development; cell recognition; cytoskeleton organization and biogenesis; regulation of cell migration; regulation of cell proliferation; odontogenesis of dentine-containing teeth; cell proliferation; extracellular matrix disassembly; embryonic development; morphogenesis of embryonic epithelium; hair follicle development; ureteric bud branching; cilium biogenesis; angiogenesis; cell differentiation; neural crest cell migration; morphogenesis of a polarized epithelium; lung development
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 Research Articles on LAMA5    1. Laminin-5 is a useful biomarker in the evaluation of invasiveness in cervical adenocarcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-LAMA5 antibodyDiseases associated with anti-LAMA5 antibody
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >5 publications with LAMA5 and Kidney Diseases
 Congenital Abnormalities Antibodies  >4 publications with LAMA5 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >3 publications with LAMA5 and Disease Models, Animal
 Inflammation Antibodies  >2 publications with LAMA5 and Inflammation
 Cardiovascular Diseases Antibodies  >1 publications with LAMA5 and Cardiovascular Diseases
 Neoplasms Antibodies  >1 publications with LAMA5 and Neoplasms
Organs/Tissues associated with anti-LAMA5 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >10 publications with LAMA5 and Kidney
 Embryonic Tissue Antibodies  >10 publications with LAMA5 and Embryonic Tissue
 Lung Antibodies  >5 publications with LAMA5 and Lung
 Vascular Antibodies  >5 publications with LAMA5 and Vascular
 Skin Antibodies  >5 publications with LAMA5 and Skin
 Placenta Antibodies  >3 publications with LAMA5 and Placenta
 Liver Antibodies  >2 publications with LAMA5 and Liver
 Mouth Antibodies  >2 publications with LAMA5 and Mouth
 Heart Antibodies  >2 publications with LAMA5 and Heart
 Spleen Antibodies  >1 publications with LAMA5 and Spleen
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