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anti-LAMB1 antibody :: Rabbit anti-Human, mouse LAMB1 Antibody

Scan QR to view Datasheet Catalog #    MBS003981 anti-LAMB1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LAMB1, Antibody

 Also Known As   

Rabbit LAMB1 Antibody

 Product Gene Name   

anti-LAMB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (107564246..107643804, complement). Location: 7q22
 OMIM    150240
 3D Structure    ModBase 3D Structure for P07942
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-LAMB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LAMB1 antibody   

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for LAMB1. It may not necessarily be applicable to this product.
 NCBI GI #    167614504
 NCBI GeneID    3912
 NCBI Accession #    NP_002282.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002291.2 [Other Products]
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 UniProt Primary Accession #    P07942 [Other Products]
 UniProt Secondary Accession #    Q14D91 [Other Products]
 UniProt Related Accession #    P07942 [Other Products]
 Molecular Weight    198,038 Da
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 NCBI Official Full Name    laminin subunit beta-1
 NCBI Official Synonym Full Names    laminin, beta 1
 NCBI Official Symbol    LAMB1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    laminin subunit beta-1; laminin B1 chain
 UniProt Protein Name    Laminin subunit beta-1
 UniProt Synonym Protein Names   
Laminin B1 chain; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta
 Protein Family    Maltoporin
 UniProt Gene Name    LAMB1 [Similar Products]
 UniProt Entry Name    LAMB1_HUMAN
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 NCBI Summary for LAMB1    Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]
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 UniProt Comments for LAMB1    LAMB1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: extracellular matrix; extracellular space; laminin-8 complex; laminin-1 complex; laminin-2 complex; perinuclear region of cytoplasm; laminin-10 complex; extracellular region; basement membrane

Molecular Function: integrin binding; enzyme binding; extracellular matrix structural constituent; glycosphingolipid binding; structural molecule activity

Biological Process: odontogenesis; axon guidance; extracellular matrix disassembly; extracellular matrix organization and biogenesis; neuronal-glial interaction involved in cerebral cortex radial glia guided migration; negative regulation of cell adhesion; cell adhesion; neurite development; positive regulation of epithelial cell proliferation; embryo implantation; positive regulation of cell migration

Disease: Lissencephaly 5
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 Research Articles on LAMB1    1. results suggest that Lm3B11/3B21 may be required for normal mature vessels and interfere with tumor angiogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LAMB1 antibodyPathways associated with anti-LAMB1 antibody
 Reference Product  PubMed Publications
 ACHE antibody  >1 publications with LAMB1 and ACHE
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with anti-LAMB1 antibodyOrgans/Tissues associated with anti-LAMB1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with LAMB1 and Neoplasms
 Nervous System Diseases Antibodies  >7 publications with LAMB1 and Nervous System Diseases
 Kidney Diseases Antibodies  >5 publications with LAMB1 and Kidney Diseases
 Brain Diseases Antibodies  >4 publications with LAMB1 and Brain Diseases
 Inflammation Antibodies  >3 publications with LAMB1 and Inflammation
 Cardiovascular Diseases Antibodies  >3 publications with LAMB1 and Cardiovascular Diseases
 Colitis, Ulcerative Antibodies  >3 publications with LAMB1 and Colitis, Ulcerative
 Drug Toxicity Antibodies  >2 publications with LAMB1 and Drug Toxicity
 Coloboma Antibodies  >2 publications with LAMB1 and Coloboma
 Heart Diseases Antibodies  >2 publications with LAMB1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >12 publications with LAMB1 and Embryonic Tissue
 Kidney Antibodies  >11 publications with LAMB1 and Kidney
 Vascular Antibodies  >10 publications with LAMB1 and Vascular
 Brain Antibodies  >10 publications with LAMB1 and Brain
 Blood Antibodies  >9 publications with LAMB1 and Blood
 Eye Antibodies  >7 publications with LAMB1 and Eye
 Muscle Antibodies  >5 publications with LAMB1 and Muscle
 Nerve Antibodies  >4 publications with LAMB1 and Nerve
 Testis Antibodies  >3 publications with LAMB1 and Testis
 Ganglia Antibodies  >3 publications with LAMB1 and Ganglia
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