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anti-LAMB2 antibody :: Rabbit LAMB2 Antibody

Scan QR to view Datasheet Catalog #    MBS003909
Western Blot
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LAMB2, Antibody

★Popular Item★
 Also Known As   

Rabbit LAMB2 Antibody

 Product Gene Name   

anti-LAMB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (49158547..49170599, complement). Location: 3p21
 OMIM    150325
 3D Structure    ModBase 3D Structure for P55268
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Specificity    LAMB2 antibody detects endogenous levels of total LAMB2 protein.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human LAMB2.
 Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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 Other Notes    Small volumes of anti-LAMB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LAMB2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-LAMB2 antibody    WB: 1:500~1:1000
ELISA: 1:5000
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 Western Blot of anti-LAMB2 antibody    anti-LAMB2 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for LAMB2. It may not necessarily be applicable to this product.
 NCBI GI #    119703755
 NCBI GeneID    3913
 NCBI Accession #    NP_002283.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002292.3 [Other Products]
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 UniProt Primary Accession #    P55268 [Other Products]
 UniProt Secondary Accession #    Q16321 [Other Products]
 UniProt Related Accession #    P55268 [Other Products]
 Molecular Weight    195,981 Da
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 NCBI Official Full Name    laminin subunit beta-2
 NCBI Official Synonym Full Names    laminin, beta 2 (laminin S)
 NCBI Official Symbol    LAMB2 [Similar Products]
 NCBI Official Synonym Symbols   
LAMS; NPHS5
[Similar Products]
 NCBI Protein Information    laminin subunit beta-2; laminin S; S-LAM beta; laminin B1s chain; S-laminin subunit beta
 UniProt Protein Name    Laminin subunit beta-2
 UniProt Synonym Protein Names   
Laminin B1s chain; Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-laminin subunit beta
 Protein Family    Laminin
 UniProt Gene Name    LAMB2 [Similar Products]
 UniProt Synonym Gene Names    LAMS; S-LAM beta [Similar Products]
 UniProt Entry Name    LAMB2_HUMAN
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 NCBI Summary for LAMB2    Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011]
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 UniProt Comments for LAMB2    LAMB2: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMB2 are the cause of Pierson syndrome (PIERSS); also known as microcoria-congenital nephrotic syndrome. Pierson syndrome is characterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome. Defects in LAMB2 are the cause of nephrotic syndrome type 5 with or without ocular abnormalities (NPHS5). NPHS5 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. NPHS5 is characterized by very early onset of progressive renal failure. A subset of patients may develop mild ocular anomalies, such as myopia, nystagmus, and strabismus.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Extracellular matrix; Secreted

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: extracellular matrix; laminin-3 complex; extracellular region; basement membrane; synapse; basal lamina

Molecular Function: integrin binding; structural molecule activity

Biological Process: axon guidance; extracellular matrix organization and biogenesis; Schwann cell development; visual perception; retina development in camera-type eye; axon extension involved in regeneration; cell adhesion; astrocyte development; neuromuscular junction development

Disease: Nephrotic Syndrome, Type 5, With Or Without Ocular Abnormalities; Pierson Syndrome
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 Research Articles on LAMB2    1. Comprehensive gene sequencing revealed a novel LAMB2 variant (c.440A --> G; His147R) that was homozygous in the 9 living, affected family members, observed at a frequency of 2.1% in the Old Order Mennonite population, and absent in 91 non-Mennonite controls
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-LAMB2 antibodyDiseases associated with anti-LAMB2 antibody
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >33 publications with LAMB2 and Kidney Diseases
 Pierson syndrome Antibodies  >24 publications with LAMB2 and Pierson syndrome
 Proteinuria Antibodies  >13 publications with LAMB2 and Proteinuria
 Neoplasms Antibodies  >4 publications with LAMB2 and Neoplasms
 Cataract Antibodies  >3 publications with LAMB2 and Cataract
 Glomerulonephritis Antibodies  >3 publications with LAMB2 and Glomerulonephritis
 Renal Insufficiency Antibodies  >2 publications with LAMB2 and Renal Insufficiency
 Kidney Failure, Chronic Antibodies  >2 publications with LAMB2 and Kidney Failure, Chronic
 Edema Antibodies  >1 publications with LAMB2 and Edema
 Heart Diseases Antibodies  >1 publications with LAMB2 and Heart Diseases
Organs/Tissues associated with anti-LAMB2 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >23 publications with LAMB2 and Kidney
 Eye Antibodies  >19 publications with LAMB2 and Eye
 Muscle Antibodies  >11 publications with LAMB2 and Muscle
 Brain Antibodies  >4 publications with LAMB2 and Brain
 Ovary Antibodies  >2 publications with LAMB2 and Ovary
 Skin Antibodies  >2 publications with LAMB2 and Skin
 Blood Antibodies  >2 publications with LAMB2 and Blood
 Vascular Antibodies  >2 publications with LAMB2 and Vascular
 Nerve Antibodies  >2 publications with LAMB2 and Nerve
 Mouth Antibodies  >1 publications with LAMB2 and Mouth
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