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anti-LAMC3 antibody :: Rabbit anti-Human, mouse LAMC3 Antibody

Scan QR to view Datasheet Catalog #    MBS000712 anti-LAMC3 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LAMC3, Antibody

 Also Known As   

Rabbit LAMC3 Antibody

 Product Gene Name   

anti-LAMC3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (133884504..133968446). Location: 9q31-q34
 OMIM    604349
 3D Structure    ModBase 3D Structure for Q9Y6N6
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-LAMC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LAMC3 antibody   

Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for LAMC3. It may not necessarily be applicable to this product.
 NCBI GI #    110611156
 NCBI GeneID    10319
 NCBI Accession #    NP_006050.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_006059.3 [Other Products]
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 UniProt Primary Accession #    Q9Y6N6 [Other Products]
 UniProt Secondary Accession #    Q59H72; B1APX9; B1APY0 [Other Products]
 UniProt Related Accession #    Q9Y6N6 [Other Products]
 Molecular Weight    171,227 Da
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 NCBI Official Full Name    laminin subunit gamma-3
 NCBI Official Synonym Full Names    laminin, gamma 3
 NCBI Official Symbol    LAMC3 [Similar Products]
 NCBI Official Synonym Symbols   
OCCM
[Similar Products]
 NCBI Protein Information    laminin subunit gamma-3; laminin-12 subunit gamma; laminin-14 subunit gamma; laminin-15 subunit gamma
 UniProt Protein Name    Laminin subunit gamma-3
 UniProt Synonym Protein Names   
Laminin-12 subunit gamma; Laminin-14 subunit gamma; Laminin-15 subunit gamma
 Protein Family    Laminin
 UniProt Gene Name    LAMC3 [Similar Products]
 UniProt Entry Name    LAMC3_HUMAN
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 NCBI Summary for LAMC3    Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq, Aug 2011]
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 UniProt Comments for LAMC3    LAMC3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMC3 are the cause of cortical malformations occipital (OCCM). OCCM is a disease in which affected individuals develop seizures, sometimes associated with transient visual changes. Brain MRI shows both pachygyria and polymicrogyria restricted to the lateral occipital lobes.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Extracellular matrix; Secreted

Chromosomal Location of Human Ortholog: 9q34.12

Cellular Component: proteinaceous extracellular matrix; membrane; extracellular region; basement membrane

Molecular Function: structural molecule activity

Biological Process: cellular morphogenesis during differentiation; extracellular matrix organization and biogenesis; visual perception; retina development in camera-type eye; cell adhesion; astrocyte development

Disease: Cortical Malformations, Occipital
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 Research Articles on LAMC3    1. Recessive LAMC3 mutations cause malformations of occipital cortical development.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-LAMC3 antibodyDiseases associated with anti-LAMC3 antibody
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with LAMC3 and Neoplasms
 Child Development Disorders, Pervasive Antibodies  >2 publications with LAMC3 and Child Development Disorders, Pervasive
 Central Nervous System Diseases Antibodies  >1 publications with LAMC3 and Central Nervous System Diseases
 Maxillofacial Abnormalities Antibodies  >1 publications with LAMC3 and Maxillofacial Abnormalities
 Intracranial Hypertension Antibodies  >1 publications with LAMC3 and Intracranial Hypertension
 Urinary Bladder Neoplasms Antibodies  >1 publications with LAMC3 and Urinary Bladder Neoplasms
 Hydrocephalus Antibodies  >1 publications with LAMC3 and Hydrocephalus
 Neurobehavioral Manifestations Antibodies  >1 publications with LAMC3 and Neurobehavioral Manifestations
 Brain Diseases Antibodies  >1 publications with LAMC3 and Brain Diseases
Organs/Tissues associated with anti-LAMC3 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with LAMC3 and Brain
 Testis Antibodies  >5 publications with LAMC3 and Testis
 Eye Antibodies  >4 publications with LAMC3 and Eye
 Heart Antibodies  >2 publications with LAMC3 and Heart
 Lung Antibodies  >2 publications with LAMC3 and Lung
 Embryonic Tissue Antibodies  >2 publications with LAMC3 and Embryonic Tissue
 Placenta Antibodies  >2 publications with LAMC3 and Placenta
 Mouth Antibodies  >1 publications with LAMC3 and Mouth
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