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anti-LAT antibody :: Rabbit LAT (Phospho-Tyr191) Antibody

Scan QR to view Datasheet Catalog #    MBS003406 anti-LAT antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LAT (Phospho-Tyr191), Antibody

 Also Known As   

Rabbit LAT (Phospho-Tyr191) Antibody

 Product Gene Name   

anti-LAT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (28996147..29002104). Location: 16p11.2
 OMIM    602354
 3D Structure    ModBase 3D Structure for O43561
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-LAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LAT antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for LAT. It may not necessarily be applicable to this product.
 NCBI GI #    62739155
 NCBI GeneID    27040
 NCBI Accession #    NP_001014987.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001014987.1 [Other Products]
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 UniProt Primary Accession #    O43561 [Other Products]
 UniProt Secondary Accession #    O43919 [Other Products]
 UniProt Related Accession #    O43561 [Other Products]
 Molecular Weight    27,930 Da
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 NCBI Official Full Name    linker for activation of T-cells family member 1 isoform b
 NCBI Official Synonym Full Names    linker for activation of T cells
 NCBI Official Symbol    LAT [Similar Products]
 NCBI Official Synonym Symbols   
LAT1; pp36
[Similar Products]
 NCBI Protein Information    linker for activation of T-cells family member 1; p36-38; 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; linker for activation of T cells, transmembrane adaptor
 UniProt Protein Name    Linker for activation of T-cells family member 1
 UniProt Synonym Protein Names   
36 kDa phospho-tyrosine adapter protein; pp36; p36-38
 Protein Family    L-lysine-epsilon aminotransferase
 UniProt Gene Name    LAT [Similar Products]
 UniProt Synonym Gene Names    pp36 [Similar Products]
 UniProt Entry Name    LAT_HUMAN
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 NCBI Summary for LAT    The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LAT    LAT: an adaptor protein involved in T-cell antigen receptor (TCR) signal transduction pathway. Plays an important role downstream of protein tyrosine kinases. Essential for TCR-mediated Ras-Erk activation and calcium flux.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: signalosome; mast cell granule; plasma membrane; integral to membrane; immunological synapse; intercellular junction; lipid raft

Molecular Function: protein binding; SH3/SH2 adaptor activity; protein kinase binding

Biological Process: integrin-mediated signaling pathway; platelet activation; T cell activation; positive regulation of signal transduction; calcium-mediated signaling; mast cell degranulation; T cell receptor signaling pathway; Ras protein signal transduction; innate immune response; immune response; gene expression; inflammatory response; blood coagulation; lymphocyte homeostasis; regulation of T cell activation
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 Research Articles on LAT    1. A novel function and mechanism of TRAF6 action in the T cell receptor(TCR)-LAT signaling pathway indicates that LAT also plays an adapter role in TCR/CD28-induced activation of TRAF6.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LAT antibodyPathways associated with anti-LAT antibody
 Reference Product  PubMed Publications
 LCK antibody  >126 publications with LAT and LCK
 SYK antibody  >119 publications with LAT and SYK
 CD4 antibody  >116 publications with LAT and CD4
 ZAP70 antibody  >111 publications with LAT and ZAP70
 GRB2 antibody  >91 publications with LAT and GRB2
 CBL antibody  >38 publications with LAT and CBL
 VAV1 antibody  >35 publications with LAT and VAV1
 ITK antibody  >26 publications with LAT and ITK
 GRAP2 antibody  >24 publications with LAT and GRAP2
 GAB2 antibody  >16 publications with LAT and GAB2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 GPVI-mediated Activation Cascade Pathway antibodies  GPVI-mediated Activation Cascade Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram
Diseases associated with anti-LAT antibodyOrgans/Tissues associated with anti-LAT antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >575 publications with LAT and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >491 publications with LAT and Nervous System Diseases
 Vascular Diseases Antibodies  >467 publications with LAT and Vascular Diseases
 Carcinoma Antibodies  >172 publications with LAT and Carcinoma
 Kidney Diseases Antibodies  >156 publications with LAT and Kidney Diseases
 Hypertension Antibodies  >136 publications with LAT and Hypertension
 Liver Diseases Antibodies  >114 publications with LAT and Liver Diseases
 Anemia Antibodies  >98 publications with LAT and Anemia
 Inflammation Antibodies  >97 publications with LAT and Inflammation
 Hemorrhage Antibodies  >96 publications with LAT and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2326 publications with LAT and Blood
 Skin Antibodies  >744 publications with LAT and Skin
 Brain Antibodies  >550 publications with LAT and Brain
 Muscle Antibodies  >407 publications with LAT and Muscle
 Heart Antibodies  >407 publications with LAT and Heart
 Liver Antibodies  >370 publications with LAT and Liver
 Bone Antibodies  >315 publications with LAT and Bone
 Pancreas Antibodies  >280 publications with LAT and Pancreas
 Kidney Antibodies  >278 publications with LAT and Kidney
 Uterus Antibodies  >198 publications with LAT and Uterus
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