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anti-LILRB4 antibody :: Rabbit anti-Human LILRB4 Antibody

Scan QR to view Datasheet Catalog #    MBS003353 anti-LILRB4 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LILRB4, Antibody

 Also Known As   

Rabbit LILRB4 Antibody

 Product Gene Name   

anti-LILRB4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (55174124..55179848). Location: 19q13.4
 OMIM    604821
 3D Structure    ModBase 3D Structure for Q8NHJ6
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-LILRB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LILRB4 antibody   

Immunofluorescence (IF), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for LILRB4. It may not necessarily be applicable to this product.
 NCBI GI #    125987588
 NCBI GeneID    11006
 NCBI Accession #    NP_001074907.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001081438.1 [Other Products]
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 UniProt Primary Accession #    Q8NHJ6 [Other Products]
 UniProt Secondary Accession #    O15468; O75021; Q6FGQ9; Q8N1C7; Q8NHL5; A8MVL8 [Other Products]
 UniProt Related Accession #    Q8NHJ6 [Other Products]
 Molecular Weight    49,356 Da
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 NCBI Official Synonym Full Names    leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
 NCBI Official Symbol    LILRB4 [Similar Products]
 NCBI Official Synonym Symbols   
ILT3; LIR5; CD85K; ILT-3; LIR-5
[Similar Products]
 NCBI Protein Information    leukocyte immunoglobulin-like receptor subfamily B member 4
 UniProt Protein Name    Leukocyte immunoglobulin-like receptor subfamily B member 4
 UniProt Synonym Protein Names   
CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18
 Protein Family    Leukocyte immunoglobulin-like receptor subfamily
 UniProt Gene Name    LILRB4 [Similar Products]
 UniProt Synonym Gene Names    ILT3; LIR5; ILT-3; LIR-5 [Similar Products]
 UniProt Entry Name    LIRB4_HUMAN
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 NCBI Summary for LILRB4    This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LILRB4    LILRB4: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; receptor activity; antigen binding

Biological Process: negative regulation of osteoclast differentiation; immune system process; signal transduction
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 Research Articles on LILRB4    1. Cyclosporine up-regulated the expression of ILT3 and ILT4 on natural killer cells, which influenced their cytotoxicity against tumor cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LILRB4 antibodyPathways associated with anti-LILRB4 antibody
 Reference Product  PubMed Publications
 PTPN6 antibody  >6 publications with LILRB4 and PTPN6
 PTPN11 antibody  >6 publications with LILRB4 and PTPN11
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
Diseases associated with anti-LILRB4 antibodyOrgans/Tissues associated with anti-LILRB4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >15 publications with LILRB4 and Inflammation
 Neoplasms Antibodies  >10 publications with LILRB4 and Neoplasms
 Hypersensitivity Antibodies  >9 publications with LILRB4 and Hypersensitivity
 Disease Models, Animal Antibodies  >4 publications with LILRB4 and Disease Models, Animal
 Necrosis Antibodies  >4 publications with LILRB4 and Necrosis
 Hematologic Diseases Antibodies  >2 publications with LILRB4 and Hematologic Diseases
 Lung Diseases Antibodies  >2 publications with LILRB4 and Lung Diseases
 Carcinoma Antibodies  >2 publications with LILRB4 and Carcinoma
 Skin Diseases Antibodies  >1 publications with LILRB4 and Skin Diseases
 Pneumonia Antibodies  >1 publications with LILRB4 and Pneumonia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >78 publications with LILRB4 and Blood
 Lung Antibodies  >4 publications with LILRB4 and Lung
 Uterus Antibodies  >3 publications with LILRB4 and Uterus
 Spleen Antibodies  >3 publications with LILRB4 and Spleen
 Pancreas Antibodies  >2 publications with LILRB4 and Pancreas
 Liver Antibodies  >1 publications with LILRB4 and Liver
 Intestine Antibodies  >1 publications with LILRB4 and Intestine
 Placenta Antibodies  >1 publications with LILRB4 and Placenta
 Stomach Antibodies  >1 publications with LILRB4 and Stomach
 Kidney Antibodies  >1 publications with LILRB4 and Kidney
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