NP_001244303.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,249 Da
NCBI Official Full Name
lamin isoform D
NCBI Official Synonym Full Names
lamin A/C
NCBI Official Synonym Symbols
FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; MADA; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B [Similar Products]
NCBI Protein Information
lamin
UniProt Protein Name
Prelamin-A/C
UniProt Synonym Protein Names
Lamin-A/CAlternative name(s):70 kDa lamin; Renal carcinoma antigen NY-REN-32
UniProt Synonym Gene Names
NCBI Summary for LMNA
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
UniProt Comments for LMNA
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920).
Product References and Citations for anti-LMNA antibody
Dan Constantinescu, Stem Cells, Jan 2006; 24: 177-185. Jan Lammerding, J. Biol. Chem., Sep 2006; 281: 25768-25780. Carmen Ivorra, Genes & Dev., Feb 2006; 20: 307-320. Dayle McClintock, PNAS, Feb 2006; 103: 2154-2159.
Research Articles on LMNA
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Products associated with anti-LMNA antibody
Pathways associated with anti-LMNA antibody
Diseases associated with anti-LMNA antibody
Disease Name |
Pubmed Publications |
Cardiovascular Diseases Antibodies |
>229 publications with LMNA and Cardiovascular Diseases |
Progeria Antibodies |
>210 publications with LMNA and Progeria |
Hutchinson Gilford progeria syndrome Antibodies |
>210 publications with LMNA and Hutchinson Gilford progeria syndrome |
Heart Diseases Antibodies |
>203 publications with LMNA and Heart Diseases |
Cardiomyopathy, Dilated Antibodies |
>177 publications with LMNA and Cardiomyopathy, Dilated |
Muscular Dystrophy, Emery-Dreifuss Antibodies |
>131 publications with LMNA and Muscular Dystrophy, Emery-Dreifuss |
Lipodystrophy, Familial Partial Antibodies |
>120 publications with LMNA and Lipodystrophy, Familial Partial |
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2 Antibodies |
>120 publications with LMNA and LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2 |
Death, Sudden, Cardiac Antibodies |
>43 publications with LMNA and Death, Sudden, Cardiac |
Muscular Dystrophies, Limb-Girdle Antibodies |
>35 publications with LMNA and Muscular Dystrophies, Limb-Girdle |
Organs/Tissues associated with anti-LMNA antibody
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