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anti-Lck antibody :: Rabbit Lck (Phospho-Tyr393) Antibody

Scan QR to view Datasheet Catalog #    MBS003240 anti-Lck antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lck (Phospho-Tyr393), Antibody

 Also Known As   

Rabbit Lck (Phospho-Tyr393) Antibody

 Product Gene Name   

anti-Lck antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (32716840..32751766). Location: 1p34.3
 OMIM    153390
 3D Structure    ModBase 3D Structure for P06239
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-Lck antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-Lck antibody   

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for Lck. It may not necessarily be applicable to this product.
 NCBI GI #    112789548
 NCBI GeneID    3932
 NCBI Accession #    NP_001036236.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001042771.1 [Other Products]
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 UniProt Primary Accession #    P06239 [Other Products]
 UniProt Secondary Accession #    P07100; Q12850; Q13152; Q5TDH8; Q5TDH9; Q7RTZ3; Q96DW4; Q9NYT8; D3DPP8 [Other Products]
 UniProt Related Accession #    P06239 [Other Products]
 Molecular Weight    58,001 Da
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 NCBI Official Full Name    tyrosine-protein kinase Lck
 NCBI Official Synonym Full Names    lymphocyte-specific protein tyrosine kinase
 NCBI Official Symbol    LCK [Similar Products]
 NCBI Official Synonym Symbols   
LSK; YT16; p56lck; pp58lck
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase Lck; leukocyte C-terminal Src kinase; p56(LSTRA) protein-tyrosine kinase; t cell-specific protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; lymphocyte cell-specific protein-tyrosine kinase; T-lymphocyte specific protein tyrosine kinase p56lck
 UniProt Protein Name    Tyrosine-protein kinase Lck
 UniProt Synonym Protein Names   
Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    LCK [Similar Products]
 UniProt Synonym Gene Names    LSK [Similar Products]
 UniProt Entry Name    LCK_HUMAN
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 NCBI Summary for Lck    This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Lck    Lck: a tyrosine kinase of the Src family that is crucial to antigen-receptor signaling in lymphocytes. plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Binds to the cytoplasmic domain of cell surface receptors, such as CD2, CD4, CD5, CD8, CD44, CD45 and CD122. Also binds to effector molecules, such as PI4K, VAV1, RASA1, FYB and to other protein kinases including CDC2, RAF1, ZAP70 and SYK. Binds to phosphatidylinositol 3'-kinase (PI3K) from T-lymphocytes through its SH3 domain and to the tyrosine phosphorylated form of Sam68 through its SH2 domain. Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Overexpression in mice leads to thymic tumors. Aberrant expression is seen in T cell leukemias and colon cancer. The leukemic translocation t(1;7)(p34;q34) has breakpoints at the T cell receptor gene and close to the Lck promoters, can cause increased Lck expression, and in one case, point mutations. A mutated Lck has also been seen in a cell line. One patient with aberrant Lck splicing suffered from SCID-like T cell deficiency. Inhibitor: BMS-279700. Three alternatively spliced isoforms of the human proteinhave been described.

Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Oncoprotein; EC 2.7.10.2; Kinase, protein; TK group; Src family

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: pericentriolar material; extrinsic to internal side of plasma membrane; endocytic vesicle; plasma membrane; immunological synapse; intercellular junction; cytosol; lipid raft

Molecular Function: protein C-terminus binding; CD8 receptor binding; identical protein binding; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine phosphatase activity; protein kinase binding; protein phosphatase binding; antigen binding; ATPase binding; protein binding; protein-tyrosine kinase activity; protein complex binding; phosphoinositide 3-kinase binding; SH2 domain binding; glycoprotein binding; CD4 receptor binding; ATP binding

Biological Process: nerve growth factor receptor signaling pathway; viral reproduction; T cell receptor signaling pathway; protein amino acid phosphorylation; B cell receptor signaling pathway; positive regulation of T cell receptor signaling pathway; hemopoiesis; positive regulation of gamma-delta T cell differentiation; T cell differentiation; aging; caspase activation; regulation of lymphocyte activation; response to drug; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; cellular zinc ion homeostasis; regulation of defense response to virus by virus; regulation of cell proliferation; dephosphorylation; response to hydrogen peroxide; positive regulation of tyrosine phosphorylation of Stat5 protein; response to zinc ion; response to mechanical stimulus; release of sequestered calcium ion into cytosol; T cell costimulation; innate immune response; positive regulation of T cell activation; blood coagulation; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Immunodeficiency 22
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 Research Articles on Lck    1. conformational states regulate clustering in early T cell signaling
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Lck antibodyPathways associated with anti-Lck antibody
 Reference Product  PubMed Publications
 CD4 antibody  >769 publications with Lck and CD4
 ZAP70 antibody  >270 publications with Lck and ZAP70
 PTPRC antibody  >202 publications with Lck and PTPRC
 CD28 antibody  >159 publications with Lck and CD28
 SYK antibody  >134 publications with Lck and SYK
 LAT antibody  >126 publications with Lck and LAT
 CSK antibody  >95 publications with Lck and CSK
 CD2 antibody  >79 publications with Lck and CD2
 MAPK1 antibody  >50 publications with Lck and MAPK1
 CBL antibody  >49 publications with Lck and CBL
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Atypical NF-kappaB Pathway antibodies  Atypical NF-kappaB Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
Diseases associated with anti-Lck antibodyOrgans/Tissues associated with anti-Lck antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >388 publications with Lck and Neoplasms
 Necrosis Antibodies  >54 publications with Lck and Necrosis
 Inflammation Antibodies  >53 publications with Lck and Inflammation
 Neoplasms, Experimental Antibodies  >47 publications with Lck and Neoplasms, Experimental
 Lung Diseases Antibodies  >29 publications with Lck and Lung Diseases
 Adenocarcinoma Antibodies  >28 publications with Lck and Adenocarcinoma
 Drug Toxicity Antibodies  >18 publications with Lck and Drug Toxicity
 Breast Neoplasms Antibodies  >17 publications with Lck and Breast Neoplasms
 Liver Diseases Antibodies  >16 publications with Lck and Liver Diseases
 Kidney Diseases Antibodies  >12 publications with Lck and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1797 publications with Lck and Blood
 Thymus Antibodies  >279 publications with Lck and Thymus
 Spleen Antibodies  >113 publications with Lck and Spleen
 Lymph Node Antibodies  >62 publications with Lck and Lymph Node
 Lymph Antibodies  >59 publications with Lck and Lymph
 Lung Antibodies  >47 publications with Lck and Lung
 Liver Antibodies  >45 publications with Lck and Liver
 Brain Antibodies  >45 publications with Lck and Brain
 Heart Antibodies  >40 publications with Lck and Heart
 Vascular Antibodies  >34 publications with Lck and Vascular
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