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anti-M-CSF Receptor antibody :: Rabbit M-CSF Receptor (Ab-809) Antibody

Scan QR to view Datasheet Catalog #    MBS002565 anti-M-CSF Receptor antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

M-CSF Receptor (Ab-809), Antibody

 Also Known As   

Rabbit M-CSF Receptor (Ab-809) Antibody

 Product Gene Name   

anti-M-CSF Receptor antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (149432854..149492935, complement). Location: 5q32
 OMIM    164770
 3D Structure    ModBase 3D Structure for P07333
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-M-CSF Receptor antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-M-CSF Receptor antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for M-CSF Receptor. It may not necessarily be applicable to this product.
 NCBI GI #    27262659
 NCBI GeneID    1436
 NCBI Accession #    NP_005202.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005211.3 [Other Products]
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 UniProt Primary Accession #    P07333 [Other Products]
 UniProt Secondary Accession #    Q6LDW5; Q6LDY4; Q86VW7; D3DQG2 [Other Products]
 UniProt Related Accession #    P07333 [Other Products]
 Molecular Weight    107,984 Da
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 NCBI Official Full Name    macrophage colony-stimulating factor 1 receptor
 NCBI Official Synonym Full Names    colony stimulating factor 1 receptor
 NCBI Official Symbol    CSF1R [Similar Products]
 NCBI Official Synonym Symbols   
FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R
[Similar Products]
 NCBI Protein Information    macrophage colony-stimulating factor 1 receptor; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; proto-oncogene c-Fms; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog
 UniProt Protein Name    Macrophage colony-stimulating factor 1 receptor
 UniProt Synonym Protein Names   
CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115
 UniProt Gene Name    CSF1R [Similar Products]
 UniProt Synonym Gene Names    FMS; CSF-1-R; CSF-1R; M-CSF-R [Similar Products]
 UniProt Entry Name    CSF1R_HUMAN
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 NCBI Summary for M-CSF Receptor    The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]
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 UniProt Comments for M-CSF Receptor    CSFR: an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors.

Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Oncoprotein; Kinase, protein; EC 2.7.10.1; TK group; PDGFR family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: macrophage colony stimulating factor receptor activity; protein homodimerization activity; cytokine binding; protein phosphatase binding; ATP binding

Biological Process: regulation of bone resorption; macrophage differentiation; phosphoinositide-mediated signaling; peptidyl-tyrosine phosphorylation; monocyte differentiation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; multicellular organismal development; osteoclast differentiation; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; cell proliferation; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; phosphatidylinositol metabolic process; positive regulation of protein amino acid phosphorylation; intercellular junction maintenance; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration

Disease: Leukoencephalopathy, Diffuse Hereditary, With Spheroids
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 Research Articles on M-CSF Receptor    1. Data indicate that blood treated with EDTA and refrigerated maintained CD115 stability.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-M-CSF Receptor antibodyPathways associated with anti-M-CSF Receptor antibody
 Reference Product  PubMed Publications
 CSF1 antibody  >66 publications with M-CSF Receptor and CSF1
 GRB2 antibody  >52 publications with M-CSF Receptor and GRB2
 CBL antibody  >37 publications with M-CSF Receptor and CBL
 LYN antibody  >26 publications with M-CSF Receptor and LYN
 INPPL1 antibody  >16 publications with M-CSF Receptor and INPPL1
 SHC1 antibody  >15 publications with M-CSF Receptor and SHC1
 FYN antibody  >13 publications with M-CSF Receptor and FYN
 SOCS3 antibody  >12 publications with M-CSF Receptor and SOCS3
 SOCS1 antibody  >10 publications with M-CSF Receptor and SOCS1
 SOS1 antibody  >3 publications with M-CSF Receptor and SOS1
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
Diseases associated with anti-M-CSF Receptor antibodyOrgans/Tissues associated with anti-M-CSF Receptor antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1340 publications with M-CSF Receptor and Neoplasms
 Necrosis Antibodies  >1203 publications with M-CSF Receptor and Necrosis
 Inflammation Antibodies  >615 publications with M-CSF Receptor and Inflammation
 Leukemia, Myeloid, Acute Antibodies  >370 publications with M-CSF Receptor and Leukemia, Myeloid, Acute
 Lung Diseases Antibodies  >267 publications with M-CSF Receptor and Lung Diseases
 Lymphoma Antibodies  >155 publications with M-CSF Receptor and Lymphoma
 Cardiovascular Diseases Antibodies  >155 publications with M-CSF Receptor and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >150 publications with M-CSF Receptor and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >144 publications with M-CSF Receptor and Breast Neoplasms
 Drug Toxicity Antibodies  >124 publications with M-CSF Receptor and Drug Toxicity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2997 publications with M-CSF Receptor and Blood
 Bone Antibodies  >1815 publications with M-CSF Receptor and Bone
 Bone Marrow Antibodies  >1346 publications with M-CSF Receptor and Bone Marrow
 Lung Antibodies  >379 publications with M-CSF Receptor and Lung
 Spleen Antibodies  >249 publications with M-CSF Receptor and Spleen
 Brain Antibodies  >209 publications with M-CSF Receptor and Brain
 Liver Antibodies  >183 publications with M-CSF Receptor and Liver
 Kidney Antibodies  >124 publications with M-CSF Receptor and Kidney
 Muscle Antibodies  >120 publications with M-CSF Receptor and Muscle
 Embryonic Tissue Antibodies  >119 publications with M-CSF Receptor and Embryonic Tissue
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