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anti-M-CS antibody :: M-CSF Receptor Antibody

Scan QR to view Datasheet Catalog #    MBS859977
Western Blot (WB)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

M-CSF Receptor, Antibody

 Also Known As   

M-CSF Receptor (Phospho-Tyr809) Antibody

 Product Synonym Names    CD115; CSF-1-R; CSF1R; CSFMR; EC 2.7.10.1; FMS; Fms proto-oncogene; M-CSFR; Macrophage colony stimulating factor I receptor precursor; c-fms; kinase CSFR
 Product Gene Name   

anti-M-CS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164770
 3D Structure    ModBase 3D Structure for P07333
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    M-CSF Receptor (Phospho-Tyr809) antibody detects endogenous levels of M-CSF Receptor only when phosphorylated at tyrosine 809.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human M-CSF Receptor around the phosphorylation site of tyrosine 809 (S-N-YP-V-V).
 All Sites    Human: Tyr809
Mouse: Tyr807
Rat: Tyr807
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-M-CS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-M-CS antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-M-CS antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-M-CS antibody    WB: 1:500-1:1000
ELISA: 1:1000
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 Western Blot (WB) of anti-M-CS antibody    Western blot analysis of extracts from 293 cells, treated with LPS (100ng/ml, 30mins), using M-CSF Receptor (Phospho-Tyr809) antibody.
anti-M-CS antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for M-CS. It may not necessarily be applicable to this product.
 NCBI GI #    569026720
 NCBI GeneID    1436
 NCBI Accession #    NP_001275634.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001288705.2 [Other Products]
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 UniProt Primary Accession #    P07333 [Other Products]
 UniProt Secondary Accession #    Q6LDW5; Q6LDY4; Q86VW7; B5A955; D3DQG2 [Other Products]
 UniProt Related Accession #    P07333 [Other Products]
 Molecular Weight    33,248 Da
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 NCBI Official Full Name    macrophage colony-stimulating factor 1 receptor
 NCBI Official Synonym Full Names    colony stimulating factor 1 receptor
 NCBI Official Symbol    CSF1R [Similar Products]
 NCBI Official Synonym Symbols   
FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R
[Similar Products]
 NCBI Protein Information    macrophage colony-stimulating factor 1 receptor
 UniProt Protein Name    Macrophage colony-stimulating factor 1 receptor
 UniProt Synonym Protein Names   
CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115
 UniProt Gene Name    CSF1R [Similar Products]
 UniProt Synonym Gene Names    FMS; CSF-1-R; CSF-1R; M-CSF-R [Similar Products]
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 NCBI Summary for M-CS    The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017]
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 UniProt Comments for M-CS    Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.
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Product References and Citations for anti-M-CS antibody

   BC Gliniak, Mol. Biol. Cell, May 1992; 3: 535. T Inaba, J. Biol. Chem., Mar 1992; 267: 5693-5699. Shinya Suzu, Blood, Apr 2005; 105: 3230-3237. Shin-ichi Murase, J. Neurosci., Dec 1998; 18: 10481.
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 Research Articles on M-CS    1. Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-M-CS antibodyPathways associated with anti-M-CS antibody
 Reference Product  PubMed Publications
 CSF1 antibody  >113 publications with M-CS and CSF1
 GRB2 antibody  >53 publications with M-CS and GRB2
 CBL antibody  >41 publications with M-CS and CBL
 MYB antibody  >21 publications with M-CS and MYB
 SHC1 antibody  >15 publications with M-CS and SHC1
 SOCS1 antibody  >13 publications with M-CS and SOCS1
 IL34 antibody  >7 publications with M-CS and IL34
 SPI1 antibody  >2 publications with M-CS and SPI1
 PIK3R1 antibody  >1 publications with M-CS and PIK3R1
 ITGAV antibody  >1 publications with M-CS and ITGAV
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
Diseases associated with anti-M-CS antibodyOrgans/Tissues associated with anti-M-CS antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1328 publications with M-CS and Necrosis
 Inflammation Antibodies  >816 publications with M-CS and Inflammation
 Leukemia, Myeloid, Acute Antibodies  >386 publications with M-CS and Leukemia, Myeloid, Acute
 Lung Diseases Antibodies  >328 publications with M-CS and Lung Diseases
 Death Antibodies  >305 publications with M-CS and Death
 Cardiovascular Diseases Antibodies  >182 publications with M-CS and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >182 publications with M-CS and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >170 publications with M-CS and Neoplasms, Experimental
 Atherosclerosis Antibodies  >98 publications with M-CS and Atherosclerosis
 Lung Neoplasms Antibodies  >90 publications with M-CS and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3302 publications with M-CS and Blood
 Bone Antibodies  >2064 publications with M-CS and Bone
 Bone Marrow Antibodies  >1499 publications with M-CS and Bone Marrow
 Lung Antibodies  >450 publications with M-CS and Lung
 Spleen Antibodies  >284 publications with M-CS and Spleen
 Liver Antibodies  >225 publications with M-CS and Liver
 Kidney Antibodies  >152 publications with M-CS and Kidney
 Muscle Antibodies  >144 publications with M-CS and Muscle
 Lymph Node Antibodies  >142 publications with M-CS and Lymph Node
 Embryonic Tissue Antibodies  >138 publications with M-CS and Embryonic Tissue
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