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anti-MADD antibody :: MADD Antibody

Scan QR to view Datasheet Catalog #    MBS851663
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MADD, Antibody

 Also Known As   

MADD Antibody

 Product Synonym Names    MAP kinase-activating death domain protein; Differentially expressed in normal and neoplastic cells; Insulinoma glucagonoma clone 20; Rab3 GDP/GTP exchange factor; MADD; DENN; IG20; KIAA0358
 Product Gene Name   

anti-MADD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603584
 3D Structure    ModBase 3D Structure for Q8WXG6
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    MADD antibody detects endogenous levels of total MADD protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human MADD.
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-MADD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MADD antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-MADD antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-MADD antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:1000
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 Testing Data of anti-MADD antibody    Peptide-+
anti-MADD antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-MADD antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using MADD antibody. Western blot analysis of extracts from COLO cells, HeLa cells and Jurkat cells, using MADD antibody.
anti-MADD antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-MADD antibody    Peptide-+ Immunofluorescence analysis of A549 cells, using MADD antibody.
anti-MADD antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for MADD. It may not necessarily be applicable to this product.
 NCBI GI #    209862998
 NCBI GeneID    8567
 NCBI Accession #    NP_001129415.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135943.1 [Other Products]
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 UniProt Primary Accession #    Q8WXG6 [Other Products]
 UniProt Secondary Accession #    O15065; O15293; Q15732; Q15741; Q8IWD7; Q8WXG3; Q8WXG4; Q8WXG5; A8K8S7; B5MEE5; D3DQR4 [Other Products]
 UniProt Related Accession #    Q8WXG6 [Other Products]
 Molecular Weight    171,006 Da
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 NCBI Official Full Name    MAP kinase-activating death domain protein isoform i
 NCBI Official Synonym Full Names    MAP kinase activating death domain
 NCBI Official Symbol    MADD [Similar Products]
 NCBI Official Synonym Symbols   
DENN; IG20; RAB3GEP
[Similar Products]
 NCBI Protein Information    MAP kinase-activating death domain protein
 UniProt Protein Name    MAP kinase-activating death domain protein
 UniProt Synonym Protein Names   
Differentially expressed in normal and neoplastic cells; Insulinoma glucagonoma clone 20; Rab3 GDP/GTP exchange factor
 Protein Family    Malonyl-S-ACP:biotin-protein carboxyltransferase
 UniProt Gene Name    MADD [Similar Products]
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 NCBI Summary for MADD    Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MADD    Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
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Product References and Citations for anti-MADD antibody

   Chow V.T.K., DNA Seq. 6:263-273(1996). Schievella A.R., J. Biol. Chem. 272:12069-12075(1997). Chow V.T.K., Genome 41:543-552(1998).
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 Research Articles on MADD    1. The risk of coronary disease and ischemic stroke associated with multiple polymorphisms and haplotypes of MADD and FOLH1 in Han Chinese patients are reported in association with alcohol consumption.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MADD antibodyPathways associated with anti-MADD antibody
 Reference Product  PubMed Publications
 TNFRSF10B antibody  >4 publications with MADD and TNFRSF10B
 TNFRSF10A antibody  >2 publications with MADD and TNFRSF10A
 TNFRSF1A antibody  >1 publications with MADD and TNFRSF1A
 PTPRN antibody  >1 publications with MADD and PTPRN
 PIDD antibody  >1 publications with MADD and PIDD
 Products by Pathway  Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway antibodies  Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway Diagram
 TNF Receptor Signaling Pathway antibodies  TNF Receptor Signaling Pathway Diagram
Diseases associated with anti-MADD antibodyOrgans/Tissues associated with anti-MADD antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >27 publications with MADD and Nervous System Diseases
 Necrosis Antibodies  >24 publications with MADD and Necrosis
 Neoplasms Antibodies  >16 publications with MADD and Neoplasms
 Brain Diseases Antibodies  >10 publications with MADD and Brain Diseases
 Diabetes Mellitus, Type 2 Antibodies  >7 publications with MADD and Diabetes Mellitus, Type 2
 Carcinoma Antibodies  >5 publications with MADD and Carcinoma
 Liver Diseases Antibodies  >5 publications with MADD and Liver Diseases
 Kidney Diseases Antibodies  >4 publications with MADD and Kidney Diseases
 Disease Models, Animal Antibodies  >4 publications with MADD and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >3 publications with MADD and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >38 publications with MADD and Muscle
 Blood Antibodies  >38 publications with MADD and Blood
 Brain Antibodies  >18 publications with MADD and Brain
 Kidney Antibodies  >9 publications with MADD and Kidney
 Liver Antibodies  >9 publications with MADD and Liver
 Nerve Antibodies  >9 publications with MADD and Nerve
 Heart Antibodies  >8 publications with MADD and Heart
 Lung Antibodies  >4 publications with MADD and Lung
 Skin Antibodies  >4 publications with MADD and Skin
 Thyroid Antibodies  >4 publications with MADD and Thyroid
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