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anti-MAN1B1 antibody :: Rabbit anti-Human MAN1B1 Antibody

Scan QR to view Datasheet Catalog #    MBS000494 anti-MAN1B1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAN1B1, Antibody

 Also Known As   

Rabbit MAN1B1 Antibody

 Product Gene Name   

anti-MAN1B1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (139981379..140003639). Location: 9q34
 OMIM    604346
 3D Structure    ModBase 3D Structure for Q9UKM7
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-MAN1B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MAN1B1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MAN1B1. It may not necessarily be applicable to this product.
 NCBI GI #    218749883
 NCBI GeneID    11253
 NCBI Accession #    NP_057303.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_016219.4 [Other Products]
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 UniProt Primary Accession #    Q9UKM7 [Other Products]
 UniProt Secondary Accession #    Q5VSG3; Q9BRS9; Q9Y5K7 [Other Products]
 UniProt Related Accession #    Q9UKM7 [Other Products]
 Molecular Weight    79,580 Da
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 NCBI Official Full Name    endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
 NCBI Official Synonym Full Names    mannosidase, alpha, class 1B, member 1
 NCBI Official Symbol    MAN1B1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; ER alpha 1,2-mannosidase; Man9GlcNAc2-specific processing alpha-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1
 UniProt Protein Name    Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
 UniProt Synonym Protein Names   
ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1
 Protein Family    Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
 UniProt Gene Name    MAN1B1 [Similar Products]
 UniProt Synonym Gene Names    ERMan1 [Similar Products]
 UniProt Entry Name    MA1B1_HUMAN
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 NCBI Summary for MAN1B1    This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]
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 UniProt Comments for MAN1B1    MAN1B1: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the glycosyl hydrolase 47 family.

Protein type: Membrane protein, integral; EC; Hydrolase; Glycan Metabolism - N-glycan biosynthesis; Endoplasmic reticulum; Calcium-binding

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane; vesicle

Molecular Function: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding

Biological Process: ER-associated protein catabolic process; cellular protein metabolic process; protein folding; protein amino acid N-linked glycosylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; oligosaccharide metabolic process

Disease: Mental Retardation, Autosomal Recessive 15
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 Research Articles on MAN1B1    1. Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-MAN1B1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with MAN1B1 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with MAN1B1 and Liver Diseases
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