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anti-MAP2K6 antibody :: Rabbit MAP2K6 Antibody

Scan QR to view Datasheet Catalog #    MBS8504796
Western Blot (WB)
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAP2K6, Antibody

 Also Known As   

MAP2K6 Antibody

 Product Synonym Names    MAPKK6; MEK6; MKK6; PRKMK6; SAPKK3
 Product Gene Name   

anti-MAP2K6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601254
 3D Structure    ModBase 3D Structure for P52564
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    Recombinant protein of human MAP2K6
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-MAP2K6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MAP2K6 antibody

   This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activatedprotein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as anintegration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase inresponse to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediatedsignal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cyclearrest, transcription activation and apoptosis.
 Product Categories/Family for anti-MAP2K6 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-MAP2K6 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-MAP2K6 antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Western Blot (WB) of anti-MAP2K6 antibody    Western blot analysis of extracts of HeLa cell line, using MAP2K6 antibody.
anti-MAP2K6 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MAP2K6. It may not necessarily be applicable to this product.
 NCBI GI #    14589900
 NCBI GeneID    5608
 NCBI Accession #    NP_002749.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002758.3 [Other Products]
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 UniProt Primary Accession #    P52564 [Other Products]
 UniProt Related Accession #    P52564 [Other Products]
 Molecular Weight    37kD
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 NCBI Official Full Name    dual specificity mitogen-activated protein kinase kinase 6 isoform 1
 NCBI Official Synonym Full Names    mitogen-activated protein kinase kinase 6
 NCBI Official Symbol    MAP2K6 [Similar Products]
 NCBI Official Synonym Symbols   
MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3
[Similar Products]
 NCBI Protein Information    dual specificity mitogen-activated protein kinase kinase 6
 UniProt Protein Name    Dual specificity mitogen-activated protein kinase kinase 6
 UniProt Synonym Protein Names   
MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3
 Protein Family    Dual specificity mitogen-activated protein kinase kinase
 UniProt Gene Name    MAP2K6 [Similar Products]
 UniProt Synonym Gene Names    MEK6; MKK6; PRKMK6; SKK3; MAP kinase kinase 6; MAPKK 6; MEK 6; SAPK kinase 3; SAPKK-3; SAPKK3 [Similar Products]
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 NCBI Summary for MAP2K6    This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAP2K6    Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
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 Research Articles on MAP2K6    1. acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAP2K6 antibodyPathways associated with anti-MAP2K6 antibody
 Reference Product  PubMed Publications
 MAPK14 antibody  >15 publications with MAP2K6 and MAPK14
 MAP3K5 antibody  >8 publications with MAP2K6 and MAP3K5
 TRAF6 antibody  >6 publications with MAP2K6 and TRAF6
 MAP3K4 antibody  >4 publications with MAP2K6 and MAP3K4
 STAT4 antibody  >3 publications with MAP2K6 and STAT4
 RELA antibody  >2 publications with MAP2K6 and RELA
 SMAD7 antibody  >1 publications with MAP2K6 and SMAD7
 MAPK13 antibody  >1 publications with MAP2K6 and MAPK13
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Diseases associated with anti-MAP2K6 antibodyOrgans/Tissues associated with anti-MAP2K6 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >49 publications with MAP2K6 and Neoplasms
 Necrosis Antibodies  >34 publications with MAP2K6 and Necrosis
 Inflammation Antibodies  >15 publications with MAP2K6 and Inflammation
 Adenocarcinoma Antibodies  >9 publications with MAP2K6 and Adenocarcinoma
 Nervous System Diseases Antibodies  >9 publications with MAP2K6 and Nervous System Diseases
 Breast Neoplasms Antibodies  >8 publications with MAP2K6 and Breast Neoplasms
 Brain Diseases Antibodies  >7 publications with MAP2K6 and Brain Diseases
 Cardiovascular Diseases Antibodies  >7 publications with MAP2K6 and Cardiovascular Diseases
 Liver Diseases Antibodies  >7 publications with MAP2K6 and Liver Diseases
 Neoplasms, Experimental Antibodies  >6 publications with MAP2K6 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >29 publications with MAP2K6 and Muscle
 Bone Antibodies  >19 publications with MAP2K6 and Bone
 Brain Antibodies  >12 publications with MAP2K6 and Brain
 Liver Antibodies  >11 publications with MAP2K6 and Liver
 Kidney Antibodies  >11 publications with MAP2K6 and Kidney
 Heart Antibodies  >9 publications with MAP2K6 and Heart
 Skin Antibodies  >6 publications with MAP2K6 and Skin
 Eye Antibodies  >5 publications with MAP2K6 and Eye
 Lung Antibodies  >5 publications with MAP2K6 and Lung
 Thymus Antibodies  >5 publications with MAP2K6 and Thymus
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