Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow MAP2K6  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Gamma-glutamyltransferase 4 (heavy chain, Cleaved-Thr472) (G... Antibody
 • AurB (Ab-232) Antibody
 • MT-ND5 Antibody
 • Cluster of Differentiation 3 (CD3) ELISA Kit
 • Prostaglandin E Synthase, Microsomal (PTGES) ELISA Kit
 • Adenylate Cyclase 1, Brain (ADCY1) ELISA Kit
 • Centriole and Centrosome Antibody IgM (ACA-IgM) ELISA Kit
 • Signal Transducer and Activator of Transcription 5A (STAT5A) ELISA Kit
 • Hepatitis B Virus Large Envelope Protein (HBV-LP) ELISA Kit
 • C Reactive Protein (CRP) ELISA Kit
 • Cytokeratin Low Moecular Weight (CK-LMW) ELISA Kit
 • Heat Shock Protein 27 Antibody (HSP27-AB) ELISA Kit
 • Adrenocortical Dysplasia Homolog (ACD) ELISA Kit
 • 5-Phosphoribosyl 1-Pyrophosphate (PRPP) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-MAP2K6 antibody :: Rabbit MAP2K6 Antibody

Scan QR to view Datasheet Catalog #    MBS8504796
Testing Data
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAP2K6, Antibody

 Also Known As   

MAP2K6 Antibody

 Product Synonym Names    MAPKK6; MEK6; MKK6; PRKMK6; SAPKK3;
 Product Gene Name   

anti-MAP2K6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    601254
 3D Structure    ModBase 3D Structure for P52564
Section Bar
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
Section Bar
 Immunogen    Recombinant protein of human MAP2K6
 Species    Rabbit
Section Bar
 Preparation and Storage    Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-MAP2K6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-MAP2K6 antibody

   Background: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activatedprotein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as anintegration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase inresponse to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediatedsignal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cyclearrest, transcription activation and apoptosis.
 Product Categories/Family for anti-MAP2K6 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-MAP2K6 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-MAP2K6 antibody    WB: 1:500-1:2000, IHC: 1:50-1:200
Section Bar
 Testing Data of anti-MAP2K6 antibody    Western blot analysis of extracts of HeLa cell line, using MAP2K6 antibody.
anti-MAP2K6 antibody Testing Data image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for MAP2K6. It may not necessarily be applicable to this product.
 NCBI GI #    14589900
 NCBI GeneID    5608
 NCBI Accession #    NP_002749.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002758.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P52564 [Other Products]
 UniProt Related Accession #    P52564 [Other Products]
 Molecular Weight    37kD
Table BarTOPTable Bar
 NCBI Official Full Name    dual specificity mitogen-activated protein kinase kinase 6
 NCBI Official Synonym Full Names    mitogen-activated protein kinase kinase 6
 NCBI Official Symbol    MAP2K6 [Similar Products]
 NCBI Official Synonym Symbols   
MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3
[Similar Products]
 NCBI Protein Information    dual specificity mitogen-activated protein kinase kinase 6; MEK 6; MAPKK 6; SAPK kinase 3; MAPK/ERK kinase 6; stress-activated protein kinase kinase 3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
 UniProt Protein Name    Dual specificity mitogen-activated protein kinase kinase 6
 UniProt Synonym Protein Names   
MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3
 Protein Family    Dual specificity mitogen-activated protein kinase kinase
 UniProt Gene Name    MAP2K6 [Similar Products]
 UniProt Synonym Gene Names    MEK6; MKK6; PRKMK6; SKK3; MAP kinase kinase 6; MAPKK 6; MEK 6; SAPK kinase 3; SAPKK-3; SAPKK3 [Similar Products]
 UniProt Entry Name    MP2K6_HUMAN
Section Bar
 NCBI Summary for MAP2K6    This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for MAP2K6    MKK6: a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported.

Protein type: Protein kinase, STE; EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); Kinase, protein; STE group; STE7 family

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: nucleoplasm; cytoskeleton; cytosol

Molecular Function: MAP kinase kinase activity; protein binding; protein-tyrosine kinase activity; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; DNA damage induced protein phosphorylation; apoptosis; positive regulation of apoptosis; activation of MAPK activity; stress-activated MAPK cascade; pathogenesis; toll-like receptor 3 signaling pathway; signal transduction; toll-like receptor 10 signaling pathway; ovulation cycle process; toll-like receptor 5 signaling pathway; regulation of transcription, DNA-dependent; cell cycle arrest; toll-like receptor 4 signaling pathway; cardiac muscle contraction; response to drug; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; muscle cell differentiation; positive regulation of prostaglandin secretion; toll-like receptor signaling pathway; innate immune response; positive regulation of muscle cell differentiation; toll-like receptor 9 signaling pathway; positive regulation of nitric-oxide synthase biosynthetic process
Table BarTOPTable Bar
 Research Articles on MAP2K6    1. Serine phosphorylation of p66shc is carried out by active MKK6. beta-Amyloid-induced ROS production and apoptosis increased in the presence of MKK6 and p66shc, which directly associate.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-MAP2K6 antibodyPathways associated with anti-MAP2K6 antibody
 Reference Product  PubMed Publications
 MAPK14 antibody  >18 publications with MAP2K6 and MAPK14
 MAP3K5 antibody  >10 publications with MAP2K6 and MAP3K5
 TRAF6 antibody  >7 publications with MAP2K6 and TRAF6
 MAP3K4 antibody  >4 publications with MAP2K6 and MAP3K4
 GADD45A antibody  >3 publications with MAP2K6 and GADD45A
 ZAK antibody  >1 publications with MAP2K6 and ZAK
 GADD45B antibody  >1 publications with MAP2K6 and GADD45B
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram
Diseases associated with anti-MAP2K6 antibodyOrgans/Tissues associated with anti-MAP2K6 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >36 publications with MAP2K6 and Necrosis
 Inflammation Antibodies  >16 publications with MAP2K6 and Inflammation
 Disease Models, Animal Antibodies  >12 publications with MAP2K6 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >9 publications with MAP2K6 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >9 publications with MAP2K6 and Adenocarcinoma
 Nervous System Diseases Antibodies  >9 publications with MAP2K6 and Nervous System Diseases
 Breast Neoplasms Antibodies  >8 publications with MAP2K6 and Breast Neoplasms
 Brain Diseases Antibodies  >7 publications with MAP2K6 and Brain Diseases
 Liver Diseases Antibodies  >7 publications with MAP2K6 and Liver Diseases
 Neoplasms, Experimental Antibodies  >6 publications with MAP2K6 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >30 publications with MAP2K6 and Muscle
 Bone Antibodies  >21 publications with MAP2K6 and Bone
 Brain Antibodies  >12 publications with MAP2K6 and Brain
 Liver Antibodies  >11 publications with MAP2K6 and Liver
 Kidney Antibodies  >11 publications with MAP2K6 and Kidney
 Heart Antibodies  >9 publications with MAP2K6 and Heart
 Lung Antibodies  >8 publications with MAP2K6 and Lung
 Skin Antibodies  >6 publications with MAP2K6 and Skin
 Eye Antibodies  >5 publications with MAP2K6 and Eye
 Connective Tissue Antibodies  >5 publications with MAP2K6 and Connective Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions