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anti-MAP2K7 antibody :: Rabbit MAP2K7 (Phospho-Thr275) Antibody

Scan QR to view Datasheet Catalog #    MBS003486 anti-MAP2K7 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAP2K7 (Phospho-Thr275), Antibody

 Also Known As   

Rabbit MAP2K7 (Phospho-Thr275) Antibody

 Product Gene Name   

anti-MAP2K7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (7968765..7979363). Location: 19p13.3-p13.2
 OMIM    603014
 3D Structure    ModBase 3D Structure for O14733
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-MAP2K7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MAP2K7 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MAP2K7. It may not necessarily be applicable to this product.
 NCBI GI #    21735544
 NCBI GeneID    5609
 NCBI Accession #    NP_660186.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_145185.2 [Other Products]
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 UniProt Primary Accession #    O14733 [Other Products]
 UniProt Secondary Accession #    O14648; O14816; O60452; O60453; Q1PG43; Q8IY10; B2R9S5; D6W659 [Other Products]
 UniProt Related Accession #    O14733 [Other Products]
 Molecular Weight    47,485 Da
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 NCBI Official Full Name    dual specificity mitogen-activated protein kinase kinase 7
 NCBI Official Synonym Full Names    mitogen-activated protein kinase kinase 7
 NCBI Official Symbol    MAP2K7 [Similar Products]
 NCBI Official Synonym Symbols   
MKK7; Jnkk2; MAPKK7; PRKMK7; SAPKK4; SAPKK-4
[Similar Products]
 NCBI Protein Information    dual specificity mitogen-activated protein kinase kinase 7; MEK 7; JNKK 2; MAPKK 7; SAPK kinase 4; MAPK/ERK kinase 7; MAP kinase kinase 7; JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2; stress-activated protein kinase kinase 4
 UniProt Protein Name    Dual specificity mitogen-activated protein kinase kinase 7
 UniProt Synonym Protein Names   
JNK-activating kinase 2; MAPK/ERK kinase 7; MEK 7; Stress-activated protein kinase kinase 4; SAPK kinase 4; SAPKK-4; SAPKK4; c-Jun N-terminal kinase kinase 2
 Protein Family    Dual specificity mitogen-activated protein kinase kinase
 UniProt Gene Name    MAP2K7 [Similar Products]
 UniProt Synonym Gene Names    JNKK2; MEK7; MKK7; PRKMK7; SKK4; MAP kinase kinase 7; MAPKK 7; MEK 7; SAPK kinase 4; SAPKK-4; SAPKK4; JNK kinase 2; JNKK 2 [Similar Products]
 UniProt Entry Name    MP2K7_HUMAN
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 NCBI Summary for MAP2K7    The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAP2K7    MKK7: a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported.

Protein type: EC 2.7.12.2; Protein kinase, STE; Kinase, protein; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: cytoplasm; intracellular; nucleus; cytosol

Molecular Function: protein C-terminus binding; MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; enzyme binding; protein-tyrosine kinase activity; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; JUN kinase kinase activity; protein kinase binding; protein phosphatase binding; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; apoptosis; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; pathogenesis; toll-like receptor 3 signaling pathway; signal transduction; response to osmotic stress; activation of JNK activity; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to heat; positive regulation of neuron apoptosis; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; response to UV
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 Research Articles on MAP2K7    1. Data indicate that WDR62 dimerization is required for JNK2 and MKK7beta1 recruitment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAP2K7 antibodyPathways associated with anti-MAP2K7 antibody
 Reference Product  PubMed Publications
 MAPK8 antibody  >16 publications with MAP2K7 and MAPK8
 MAP3K1 antibody  >13 publications with MAP2K7 and MAP3K1
 MAPK8IP1 antibody  >5 publications with MAP2K7 and MAPK8IP1
 GADD45B antibody  >5 publications with MAP2K7 and GADD45B
 MAP3K2 antibody  >5 publications with MAP2K7 and MAP3K2
 TRAF6 antibody  >3 publications with MAP2K7 and TRAF6
 MAP3K5 antibody  >3 publications with MAP2K7 and MAP3K5
 MAPK8IP3 antibody  >1 publications with MAP2K7 and MAPK8IP3
 MAPK8IP2 antibody  >1 publications with MAP2K7 and MAPK8IP2
 CNKSR1 antibody  >1 publications with MAP2K7 and CNKSR1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 FAS (CD95) Signaling Pathway antibodies  FAS (CD95) Signaling Pathway Diagram
Diseases associated with anti-MAP2K7 antibodyOrgans/Tissues associated with anti-MAP2K7 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >30 publications with MAP2K7 and Necrosis
 Neoplasms Antibodies  >26 publications with MAP2K7 and Neoplasms
 Inflammation Antibodies  >10 publications with MAP2K7 and Inflammation
 Hypertrophy Antibodies  >8 publications with MAP2K7 and Hypertrophy
 Cardiovascular Diseases Antibodies  >7 publications with MAP2K7 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >5 publications with MAP2K7 and Carcinoma, Hepatocellular
 Drug Toxicity Antibodies  >5 publications with MAP2K7 and Drug Toxicity
 Liver Diseases Antibodies  >5 publications with MAP2K7 and Liver Diseases
 Heart Failure Antibodies  >4 publications with MAP2K7 and Heart Failure
 Liver Neoplasms Antibodies  >4 publications with MAP2K7 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >13 publications with MAP2K7 and Liver
 Muscle Antibodies  >12 publications with MAP2K7 and Muscle
 Heart Antibodies  >12 publications with MAP2K7 and Heart
 Kidney Antibodies  >10 publications with MAP2K7 and Kidney
 Brain Antibodies  >8 publications with MAP2K7 and Brain
 Lung Antibodies  >5 publications with MAP2K7 and Lung
 Skin Antibodies  >4 publications with MAP2K7 and Skin
 Embryonic Tissue Antibodies  >4 publications with MAP2K7 and Embryonic Tissue
 Prostate Antibodies  >4 publications with MAP2K7 and Prostate
 Thymus Antibodies  >3 publications with MAP2K7 and Thymus
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