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anti-MAP3K7 antibody :: Rabbit MAP3K7 (Ab-187) Antibody

Scan QR to view Datasheet Catalog #    MBS000479 anti-MAP3K7 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAP3K7 (Ab-187), Antibody

 Also Known As   

Rabbit MAP3K7 (Ab-187) Antibody

 Product Gene Name   

anti-MAP3K7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (91223292..91297020, complement). Location: 6q15
 OMIM    602614
 3D Structure    ModBase 3D Structure for O43318
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-MAP3K7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MAP3K7 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MAP3K7. It may not necessarily be applicable to this product.
 NCBI GI #    4507361
 NCBI GeneID    6885
 NCBI Accession #    NP_003179.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003188.3 [Other Products]
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 UniProt Primary Accession #    O43318 [Other Products]
 UniProt Secondary Accession #    O43317; O43319; Q5TDN2; Q5TDN3; Q5TDT7; Q9NTR3; Q9NZ70; B2RE27; E1P523 [Other Products]
 UniProt Related Accession #    O43318 [Other Products]
 Molecular Weight    67,196 Da
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 NCBI Official Full Name    mitogen-activated protein kinase kinase kinase 7 isoform A
 NCBI Official Synonym Full Names    mitogen-activated protein kinase kinase kinase 7
 NCBI Official Symbol    MAP3K7 [Similar Products]
 NCBI Official Synonym Symbols   
TAK1; MEKK7; TGF1a
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase kinase kinase 7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1
 UniProt Protein Name    Mitogen-activated protein kinase kinase kinase 7
 UniProt Synonym Protein Names   
Transforming growth factor-beta-activated kinase 1
 Protein Family    Mitogen-activated protein kinase kinase kinase
 UniProt Gene Name    MAP3K7 [Similar Products]
 UniProt Synonym Gene Names    TAK1; TGF-beta-activated kinase 1 [Similar Products]
 UniProt Entry Name    M3K7_HUMAN
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 NCBI Summary for MAP3K7    The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAP3K7    TAK1: a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described.

Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; MLK family; TAK1 subfamily

Chromosomal Location of Human Ortholog: 6q15

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; endosome membrane; IkappaB kinase complex; cytosol; nucleus

Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding; protein kinase activity

Biological Process: positive regulation of JNK activity; I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; activation of MAPK activity; apoptosis; stress-activated MAPK cascade; positive regulation of T cell cytokine production; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; transforming growth factor beta receptor signaling pathway; JNK cascade; angiogenesis; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-2 production; toll-like receptor signaling pathway; innate immune response; positive regulation of T cell activation; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation; neural tube formation
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 Research Articles on MAP3K7    1. Results indicate that TAK1 and p38 kinases appear to be central in the 'priming effect' of LTB(4) on neutrophils to enhance response to Toll-like receptor ligands.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAP3K7 antibodyPathways associated with anti-MAP3K7 antibody
 Reference Product  PubMed Publications
 TAB2 antibody  >6 publications with MAP3K7 and TAB2
 TRAF6 antibody  >4 publications with MAP3K7 and TRAF6
 MAPK14 antibody  >3 publications with MAP3K7 and MAPK14
 MAPK8 antibody  >2 publications with MAP3K7 and MAPK8
 TNFRSF11A antibody  >2 publications with MAP3K7 and TNFRSF11A
 TAB1 antibody  >2 publications with MAP3K7 and TAB1
 IKBKB antibody  >2 publications with MAP3K7 and IKBKB
 CARD11 antibody  >2 publications with MAP3K7 and CARD11
 STAT3 antibody  >1 publications with MAP3K7 and STAT3
 SMAD3 antibody  >1 publications with MAP3K7 and SMAD3
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
Diseases associated with anti-MAP3K7 antibodyOrgans/Tissues associated with anti-MAP3K7 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13 publications with MAP3K7 and Neoplasms
 Inflammation Antibodies  >8 publications with MAP3K7 and Inflammation
 Necrosis Antibodies  >6 publications with MAP3K7 and Necrosis
 Death Antibodies  >2 publications with MAP3K7 and Death
 Disease Models, Animal Antibodies  >2 publications with MAP3K7 and Disease Models, Animal
 Kidney Diseases Antibodies  >2 publications with MAP3K7 and Kidney Diseases
 Prostatic Diseases Antibodies  >2 publications with MAP3K7 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >2 publications with MAP3K7 and Prostatic Neoplasms
 Anemia Antibodies  >1 publications with MAP3K7 and Anemia
 Heart Diseases Antibodies  >1 publications with MAP3K7 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with MAP3K7 and Blood
 Bone Antibodies  >7 publications with MAP3K7 and Bone
 Prostate Antibodies  >4 publications with MAP3K7 and Prostate
 Muscle Antibodies  >3 publications with MAP3K7 and Muscle
 Embryonic Tissue Antibodies  >3 publications with MAP3K7 and Embryonic Tissue
 Heart Antibodies  >3 publications with MAP3K7 and Heart
 Vascular Antibodies  >2 publications with MAP3K7 and Vascular
 Kidney Antibodies  >2 publications with MAP3K7 and Kidney
 Liver Antibodies  >2 publications with MAP3K7 and Liver
 Brain Antibodies  >2 publications with MAP3K7 and Brain
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