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anti-MAPKAPK-2 antibody :: MAPKAPK-2 Antibody

Scan QR to view Datasheet Catalog #    MBS857571
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAPKAPK-2, Antibody

★Popular Item★
 Also Known As   

MAPKAPK-2 (Phospho-Thr334) Antibody

 Product Gene Name   

anti-MAPKAPK-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602006
 3D Structure    ModBase 3D Structure for P49137
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    MAPKAPK-2 (Phospho-Thr334) antibody detects endogenous levels of MAPKAPK-2 only when phosphorylated at threonine 334.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human MAPKAPK-2 around the phosphorylation site of threonine 334 (P-Q-TP-P-L).
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-MAPKAPK-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MAPKAPK-2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-MAPKAPK-2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-MAPKAPK-2 antibody    WB: 1:500~1:1000
IHC: 1:50-1:100
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 Immunohistochemistry (IHC) of anti-MAPKAPK-2 antibody    P-Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using MAPKAPK-2 (Phospho-Thr334) antibody.
anti-MAPKAPK-2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-MAPKAPK-2 antibody    Western blot analysis of extract from HeLa cells treated with UV (20min), using MAPKAPK-2 (Ab-334) antibody and MAPKAPK-2 (Phospho-Thr334) antibody.
anti-MAPKAPK-2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MAPKAPK-2. It may not necessarily be applicable to this product.
 NCBI GI #    10863901
 NCBI GeneID    9261
 NCBI Accession #    NP_004750.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004759.4 [Other Products]
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 UniProt Primary Accession #    P49137 [Other Products]
 UniProt Secondary Accession #    Q5SY30; Q5SY41; Q8IYD6 [Other Products]
 UniProt Related Accession #    P49137 [Other Products]
 Molecular Weight    42,203 Da
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 NCBI Official Full Name    MAP kinase-activated protein kinase 2 isoform 1
 NCBI Official Synonym Full Names    mitogen-activated protein kinase-activated protein kinase 2
 NCBI Official Symbol    MAPKAPK2 [Similar Products]
 NCBI Official Synonym Symbols   
MK2; MK-2; MAPKAP-K2
[Similar Products]
 NCBI Protein Information    MAP kinase-activated protein kinase 2
 UniProt Protein Name    MAP kinase-activated protein kinase 2
 UniProt Gene Name    MAPKAPK2 [Similar Products]
 UniProt Synonym Gene Names    MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2 [Similar Products]
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 NCBI Summary for MAPKAPK-2    This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAPKAPK-2    Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X2-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.
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Product References and Citations for anti-MAPKAPK-2 antibody

   Rouse, J. et al. (1994) Cell 78, 1027-1037. Ben-Levy, R. et al. (1995) EMBO J. 14, 5920-5930.
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 Research Articles on MAPKAPK-2    1. According to the information mentioned above, we now report the design and synthesis of some series of new urea derivatives that were then evaluated for their inhibitory activities against MAPKAPK2, TNF-a, and p38a
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAPKAPK-2 antibodyPathways associated with anti-MAPKAPK-2 antibody
 Reference Product  PubMed Publications
 HSPB1 antibody  >49 publications with MAPKAPK-2 and HSPB1
 MAPK14 antibody  >17 publications with MAPKAPK-2 and MAPK14
 ALOX5 antibody  >7 publications with MAPKAPK-2 and ALOX5
 ZFP36 antibody  >7 publications with MAPKAPK-2 and ZFP36
 AKT1 antibody  >7 publications with MAPKAPK-2 and AKT1
 CDC25B antibody  >5 publications with MAPKAPK-2 and CDC25B
 SRF antibody  >4 publications with MAPKAPK-2 and SRF
 LSP1 antibody  >3 publications with MAPKAPK-2 and LSP1
 ETV1 antibody  >2 publications with MAPKAPK-2 and ETV1
 HSF1 antibody  >1 publications with MAPKAPK-2 and HSF1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CREB Phosphorylation Pathway antibodies  CREB Phosphorylation Pathway Diagram
 Destabilization Of MRNA By Butyrate Response Factor 1 (BRF1) Pathway antibodies  Destabilization Of MRNA By Butyrate Response Factor 1 (BRF1) Pathway Diagram
 Destabilization Of MRNA By Tristetraprolin (TTP) Pathway antibodies  Destabilization Of MRNA By Tristetraprolin (TTP) Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
Diseases associated with anti-MAPKAPK-2 antibodyOrgans/Tissues associated with anti-MAPKAPK-2 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >122 publications with MAPKAPK-2 and Necrosis
 Inflammation Antibodies  >87 publications with MAPKAPK-2 and Inflammation
 Neoplasms Antibodies  >64 publications with MAPKAPK-2 and Neoplasms
 Nervous System Diseases Antibodies  >22 publications with MAPKAPK-2 and Nervous System Diseases
 Carcinoma Antibodies  >21 publications with MAPKAPK-2 and Carcinoma
 Drug Toxicity Antibodies  >19 publications with MAPKAPK-2 and Drug Toxicity
 Heart Diseases Antibodies  >17 publications with MAPKAPK-2 and Heart Diseases
 Fibrosis Antibodies  >15 publications with MAPKAPK-2 and Fibrosis
 Hypertrophy Antibodies  >9 publications with MAPKAPK-2 and Hypertrophy
 Kidney Diseases Antibodies  >8 publications with MAPKAPK-2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >89 publications with MAPKAPK-2 and Blood
 Muscle Antibodies  >73 publications with MAPKAPK-2 and Muscle
 Vascular Antibodies  >49 publications with MAPKAPK-2 and Vascular
 Heart Antibodies  >45 publications with MAPKAPK-2 and Heart
 Brain Antibodies  >28 publications with MAPKAPK-2 and Brain
 Lung Antibodies  >28 publications with MAPKAPK-2 and Lung
 Bone Antibodies  >26 publications with MAPKAPK-2 and Bone
 Skin Antibodies  >16 publications with MAPKAPK-2 and Skin
 Kidney Antibodies  >14 publications with MAPKAPK-2 and Kidney
 Intestine Antibodies  >12 publications with MAPKAPK-2 and Intestine
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