Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow MAPKAPK2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • COL1A1 Antibody
 • NGAL (LCN2) Antibody
 • Glucocorticoid receptor (NR3C1) Recombinant Protein
 • TNFSF12 Antibody
 • Trefoil factor 1 protein (TFF1) Recombinant Protein
 • p53-tumor protein, p53-TP53 ELISA Kit
 • Adiponectin (ADIPOQ) Recombinant Protein
 • Peroxisome proliferator-activated receptor gamma (Pparg) Recombinant Protein
 • KIRREL cDNA Clone
 • Wnt3a Recombinant Protein
 • Inducible T-Cell Co Stimulator (ICOS) ELISA Kit
 • 14-3-3 beta - alpha (YWHAB) Antibody
 • T-cell surface glycoprotein CD1b (CD1B) Recombinant Protein
 • AZGP1 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-MAPKAPK2 antibody :: Rabbit MAPKAPK2 (Phospho-Ser272) Antibody

Scan QR to view Datasheet Catalog #    MBS004662
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAPKAPK2 (Phospho-Ser272), Antibody

★Popular Item★
 Also Known As   

Rabbit MAPKAPK2 (Phospho-Ser272) Antibody

 Product Gene Name   

anti-MAPKAPK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 1; NC_000001.10 (206858365..206907630). Location: 1q32
 OMIM    602006
 3D Structure    ModBase 3D Structure for P49137
Section Bar
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human (Identities = 100%, Positives = 100%);
Mouse (Identities = 100%, Positives = 100%);
Rat (Identities = 100%, Positives = 100%)
Section Bar
 Specificity    MAPKAPK2 (Phospho-Ser272) antibody detects endogenous levels of MAPKAPK2 only when phosphorylated at serine 272.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1 mg/ml (lot specific)
Section Bar
 All Sites    Human: Ser272; Mouse: Ser258; Rat: Ser258
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human MAPKAPK2 around the phosphorylation site of serine 272 (A-I-SP-P-G).
Section Bar
 Preparation and Storage    Store at -20 Degree C/1 year
 Other Notes    Small volumes of anti-MAPKAPK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-MAPKAPK2 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-MAPKAPK2 antibody    WB: 1:500~1:3000
IHC: 1:50~1:100
ELISA: 1:1000
Section Bar
 Immunohistochemistry of anti-MAPKAPK2 antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using MAPKAPK2 (Phospho-Ser272) antibody.
anti-MAPKAPK2 antibody Immunohistochemistry (IHC) image
Section Bar
  Western Blot of anti-MAPKAPK2 antibody    Western blot analysis of extracts from RAW264.7 cells, treated with UV (15mins), using MAPKAPK2 (Phospho-Ser272) antibody.
anti-MAPKAPK2 antibody  Western Blot (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for MAPKAPK2. It may not necessarily be applicable to this product.
 NCBI GI #    10863901
 NCBI GeneID    9261
 NCBI Accession #    NP_004750.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004759.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P49137 [Other Products]
 UniProt Secondary Accession #    Q5SY30; Q5SY41; Q8IYD6 [Other Products]
 UniProt Related Accession #    P49137 [Other Products]
 Molecular Weight    45,568 Da
Table BarTOPTable Bar
 NCBI Official Full Name    MAP kinase-activated protein kinase 2 isoform 1
 NCBI Official Synonym Full Names    mitogen-activated protein kinase-activated protein kinase 2
 NCBI Official Symbol    MAPKAPK2 [Similar Products]
 NCBI Official Synonym Symbols   
MK2; MK-2; MAPKAP-K2
[Similar Products]
 NCBI Protein Information    MAP kinase-activated protein kinase 2; MAPKAP kinase 2; MAPK-activated protein kinase 2
 UniProt Protein Name    MAP kinase-activated protein kinase 2
 UniProt Gene Name    MAPKAPK2 [Similar Products]
 UniProt Synonym Gene Names    MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2 [Similar Products]
 UniProt Entry Name    MAPK2_HUMAN
Section Bar
 NCBI Summary for MAPKAPK2    This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for MAPKAPK2    MAPKAPK2: a member of the MAPKAPK family of protein kinases. It is phosphorylated and activated by p38 in response to cytokines, stress and chemotactic factors.MAPKAPK-2 is apparently a direct target of p38 MAPK. HSP27 is one of its in vivo substrates. Two transcript variants encoding two different isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; CAMK group; MAPKAPK family; MAPKAPK subfamily

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: nucleoplasm; centrosome; cytoplasm; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; signal transducer activity; protein binding; ATP binding; protein kinase activity

Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; stress-activated MAPK cascade; response to lipopolysaccharide; leukotriene metabolic process; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of interleukin-6 production; arachidonic acid metabolic process; response to stress; inflammatory response; toll-like receptor 4 signaling pathway; inner ear development; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; response to cytokine stimulus; Ras protein signal transduction; toll-like receptor signaling pathway; innate immune response; regulation of tumor necrosis factor production; gene expression; toll-like receptor 9 signaling pathway; vascular endothelial growth factor receptor signaling pathway; G2/M transition DNA damage checkpoint; response to DNA damage stimulus
Table BarTOPTable Bar
 Research Articles on MAPKAPK2    1. activation of PP2A or inactivation of the p38MAPK-MAPKAPK2-Hsp27 has a role in survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-MAPKAPK2 antibodyPathways associated with anti-MAPKAPK2 antibody
 Reference Product  PubMed Publications
 HSPB1 antibody  >49 publications with MAPKAPK2 and HSPB1
 MAPK14 antibody  >17 publications with MAPKAPK2 and MAPK14
 ALOX5 antibody  >7 publications with MAPKAPK2 and ALOX5
 ZFP36 antibody  >7 publications with MAPKAPK2 and ZFP36
 AKT1 antibody  >7 publications with MAPKAPK2 and AKT1
 CDC25B antibody  >5 publications with MAPKAPK2 and CDC25B
 SRF antibody  >4 publications with MAPKAPK2 and SRF
 LSP1 antibody  >3 publications with MAPKAPK2 and LSP1
 ETV1 antibody  >2 publications with MAPKAPK2 and ETV1
 HSF1 antibody  >1 publications with MAPKAPK2 and HSF1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CREB Phosphorylation Pathway antibodies  CREB Phosphorylation Pathway Diagram
 Destabilization Of MRNA By Butyrate Response Factor 1 (BRF1) Pathway antibodies  Destabilization Of MRNA By Butyrate Response Factor 1 (BRF1) Pathway Diagram
 Destabilization Of MRNA By Tristetraprolin (TTP) Pathway antibodies  Destabilization Of MRNA By Tristetraprolin (TTP) Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
Diseases associated with anti-MAPKAPK2 antibodyOrgans/Tissues associated with anti-MAPKAPK2 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >122 publications with MAPKAPK2 and Necrosis
 Inflammation Antibodies  >87 publications with MAPKAPK2 and Inflammation
 Neoplasms Antibodies  >64 publications with MAPKAPK2 and Neoplasms
 Nervous System Diseases Antibodies  >22 publications with MAPKAPK2 and Nervous System Diseases
 Carcinoma Antibodies  >21 publications with MAPKAPK2 and Carcinoma
 Drug Toxicity Antibodies  >19 publications with MAPKAPK2 and Drug Toxicity
 Heart Diseases Antibodies  >17 publications with MAPKAPK2 and Heart Diseases
 Fibrosis Antibodies  >15 publications with MAPKAPK2 and Fibrosis
 Hypertrophy Antibodies  >9 publications with MAPKAPK2 and Hypertrophy
 Kidney Diseases Antibodies  >8 publications with MAPKAPK2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >89 publications with MAPKAPK2 and Blood
 Muscle Antibodies  >73 publications with MAPKAPK2 and Muscle
 Vascular Antibodies  >49 publications with MAPKAPK2 and Vascular
 Heart Antibodies  >45 publications with MAPKAPK2 and Heart
 Brain Antibodies  >28 publications with MAPKAPK2 and Brain
 Lung Antibodies  >28 publications with MAPKAPK2 and Lung
 Bone Antibodies  >26 publications with MAPKAPK2 and Bone
 Skin Antibodies  >16 publications with MAPKAPK2 and Skin
 Kidney Antibodies  >14 publications with MAPKAPK2 and Kidney
 Intestine Antibodies  >12 publications with MAPKAPK2 and Intestine
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions