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anti-MARK2 antibody :: Rabbit MARK2 Antibody

Scan QR to view Datasheet Catalog #    MBS000487 anti-MARK2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MARK2, Antibody

 Also Known As   

Rabbit MARK2 Antibody

 Product Gene Name   

anti-MARK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (63606400..63678492). Location: 11q13.1
 OMIM    600526
 3D Structure    ModBase 3D Structure for Q7KZI7
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-MARK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MARK2 antibody   

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MARK2. It may not necessarily be applicable to this product.
 NCBI GI #    254028234
 NCBI GeneID    2011
 NCBI Accession #    NP_001034558.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001039469.2 [Other Products]
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 UniProt Primary Accession #    Q7KZI7 [Other Products]
 UniProt Secondary Accession #    Q15449; Q15524; Q5XGA3; Q68A18; Q96HB3; Q96RG0 [Other Products]
 UniProt Related Accession #    Q7KZI7 [Other Products]
 Molecular Weight    87,911 Da
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 NCBI Official Full Name    serine/threonine-protein kinase MARK2 isoform d
 NCBI Official Synonym Full Names    MAP/microtubule affinity-regulating kinase 2
 NCBI Official Symbol    MARK2 [Similar Products]
 NCBI Official Synonym Symbols   
EMK1; EMK-1; PAR-1; Par1b; Par-1b
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase MARK2; PAR1 homolog b; ELKL motif kinase 1; Ser/Thr protein kinase PAR-1B; serine/threonine protein kinase EMK
 UniProt Protein Name    Serine/threonine-protein kinase MARK2
 UniProt Synonym Protein Names   
ELKL motif kinase 1; EMK-1; MAP/microtubule affinity-regulating kinase 2; PAR1 homolog; PAR1 homolog b
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    MARK2 [Similar Products]
 UniProt Synonym Gene Names    EMK1; EMK-1; Par-1b; Par1b [Similar Products]
 UniProt Entry Name    MARK2_HUMAN
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 NCBI Summary for MARK2    This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
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 UniProt Comments for MARK2    MARK2: a CAMK protein kinase of the CAMKL group. Plays a role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection. 12 isoforms of the human protein are produced by alternative promoter.

Protein type: EC 2.7.11.26; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.1; CAMK group; CAMKL family; MARK subfamily

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: mitochondrion; membrane; plasma membrane; actin filament; basal cortex; nucleus; lateral plasma membrane

Molecular Function: protein serine/threonine kinase activity; protein binding; tau-protein kinase activity; magnesium ion binding; protein kinase activator activity; lipid binding; ATP binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; Wnt receptor signaling pathway; establishment of cell polarity; protein amino acid autophosphorylation; mitochondrion degradation; activation of protein kinase activity; peptidyl-threonine phosphorylation; neuron migration; mitochondrion localization; regulation of axonogenesis; protein amino acid phosphorylation; regulation of cytoskeleton organization and biogenesis
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 Research Articles on MARK2    1. automated image analysis of MT assembly dynamics identified MARK2 as a target regulated downstream of Rac1 that promotes oriented MT growth in the leading edge to mediate directed cell migration.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MARK2 antibodyPathways associated with anti-MARK2 antibody
 Reference Product  PubMed Publications
 STK11 antibody  >8 publications with MARK2 and STK11
 PARD6A antibody  >1 publications with MARK2 and PARD6A
 DVL3 antibody  >1 publications with MARK2 and DVL3
 Products by Pathway  Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Regulation Of Microtubule Cytoskeleton Pathway antibodies  Regulation Of Microtubule Cytoskeleton Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
Diseases associated with anti-MARK2 antibodyOrgans/Tissues associated with anti-MARK2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with MARK2 and Neoplasms
 Immune System Diseases Antibodies  >14 publications with MARK2 and Immune System Diseases
 Carcinoma Antibodies  >10 publications with MARK2 and Carcinoma
 Kidney Diseases Antibodies  >3 publications with MARK2 and Kidney Diseases
 Inflammation Antibodies  >3 publications with MARK2 and Inflammation
 Neoplasms, Experimental Antibodies  >3 publications with MARK2 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >3 publications with MARK2 and Breast Neoplasms
 Lymphoma Antibodies  >2 publications with MARK2 and Lymphoma
 Fatty Liver Antibodies  >2 publications with MARK2 and Fatty Liver
 Necrosis Antibodies  >2 publications with MARK2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >41 publications with MARK2 and Brain
 Blood Antibodies  >21 publications with MARK2 and Blood
 Kidney Antibodies  >15 publications with MARK2 and Kidney
 Nerve Antibodies  >12 publications with MARK2 and Nerve
 Muscle Antibodies  >12 publications with MARK2 and Muscle
 Vascular Antibodies  >11 publications with MARK2 and Vascular
 Bone Antibodies  >8 publications with MARK2 and Bone
 Stomach Antibodies  >7 publications with MARK2 and Stomach
 Liver Antibodies  >7 publications with MARK2 and Liver
 Heart Antibodies  >7 publications with MARK2 and Heart
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