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anti-MBP  antibody :: Rabbit MBP  Antibody

Scan QR to view Datasheet Catalog #    MBS330026 anti-MBP  antibody
Unit / Price
0.1 mg  /  $475 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MBP , Antibody

 Also Known As   

Anti-MBP 

 Product Synonym Names    Rabbit anti-MBP (Myelin Basic Protein) antibody (affinity purified)
 Product Gene Name   

anti-MBP  antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 18; NC_000018.9 (74690789..74844774, complement). Location: 18q23
 OMIM    159430
 3D Structure    ModBase 3D Structure for P02686
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 Host    Rabbit
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 Specificity    Recognize 20 kd bovine myelin basic proteins. May cross-react with other isoforms of other mammalian myelin basic proteins as the affinity binding-sequence is identical.
 Purity/Purification    Affinity purified with pan MBP peptide (PRTPPPSQGKGRGL) on Agarose
 Form/Format    250 umg/ml in PBS. 50% glycerol
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 Immunogen    Bovine myelin basic protein (MBP)
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 Preparation and Storage    Store at -20 degree C, stable for up to three years.
 Other Notes    Small volumes of anti-MBP  antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MBP  antibody

   Affinity purified rabbit polyclonal anti-MBP antibody is developed with bovine myelin basic protein as the immunogen. The antibody is affinity purified with an immuno-dominant peptide (PRTPPPSQGKGRGL), the peptide sequence is identical for most of the isoforms of mammalian myelin basic proteins.
 Product Categories/Family for anti-MBP  antibody    For Signal Transduction
 Applications Tested/Suitable for anti-MBP  antibody   

ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for MBP . It may not necessarily be applicable to this product.
 NCBI GI #    17378805
 NCBI GeneID    4155
 NCBI Accession #    P02686.3 [Other Products]
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 UniProt Primary Accession #    P02686 [Other Products]
 UniProt Secondary Accession #    Q15337; Q15338; Q15339; Q15340; A4FU54; A6NI84; A8MY86; A8MYL4; B3KY66; B7ZKS2; B7ZKS4 [Other Products]
 UniProt Related Accession #    P02686 [Other Products]
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 NCBI Official Full Name    Myelin basic protein
 NCBI Official Synonym Full Names    myelin basic protein
 NCBI Official Symbol    MBP [Similar Products]
 NCBI Protein Information    Golli-MBP; myelin basic protein; myelin A1 protein; myelin membrane encephalitogenic protein
 UniProt Protein Name    Myelin basic protein
 UniProt Synonym Protein Names   
Myelin A1 protein; Myelin membrane encephalitogenic protein
 UniProt Gene Name    MBP [Similar Products]
 UniProt Synonym Gene Names    MBP [Similar Products]
 UniProt Entry Name    MBP_HUMAN
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 NCBI Summary for MBP     The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MBP     Function: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Ref.7

Subunit structure: Homodimer. Isoform 3 exists as a homodimer. Ref.7

Subcellular location: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic side of myelin.

Tissue specificity: MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Ref.6

Developmental stage: Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks and its relative proportion declines thereafter.

Post-translational modification: Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic. Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated. Ref.22Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1. Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28

Involvement in disease: The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).

Sequence similarities: Belongs to the myelin basic protein family.

Sequence caution: The sequence AAC41944.1 differs from that shown. Reason: Contaminating sequence. The C-terminus contains a Histidine tag.The sequence BAD92223.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence CAH10359.1 differs from that shown. Reason: wrong intron-exon boundaries.
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 Research Articles on MBP     1. Multiple sites of the cleavage of 21- and 25-mer encephalytogenic oligopeptides corresponding to human myelin basic protein (MBP) by specific anti-MBP antibodies from patients with systemic lupus erythematosus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MBP  antibodyDiseases associated with anti-MBP  antibody
 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2561 publications with MBP  and Nervous System Diseases
 Demyelinating Diseases Antibodies  >1900 publications with MBP  and Demyelinating Diseases
 Brain Diseases Antibodies  >1646 publications with MBP  and Brain Diseases
 Disease Models, Animal Antibodies  >1323 publications with MBP  and Disease Models, Animal
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >1165 publications with MBP  and Encephalomyelitis, Autoimmune, Experimental
 Cardiovascular Diseases Antibodies  >646 publications with MBP  and Cardiovascular Diseases
 Inflammation Antibodies  >447 publications with MBP  and Inflammation
 Neoplasms Antibodies  >417 publications with MBP  and Neoplasms
 Hypertension Antibodies  >392 publications with MBP  and Hypertension
 Necrosis Antibodies  >249 publications with MBP  and Necrosis
Organs/Tissues associated with anti-MBP  antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3495 publications with MBP  and Blood
 Brain Antibodies  >1773 publications with MBP  and Brain
 Nerve Antibodies  >1328 publications with MBP  and Nerve
 Spinal Cord Antibodies  >651 publications with MBP  and Spinal Cord
 Heart Antibodies  >641 publications with MBP  and Heart
 Kidney Antibodies  >257 publications with MBP  and Kidney
 Lymph Node Antibodies  >237 publications with MBP  and Lymph Node
 Lymph Antibodies  >237 publications with MBP  and Lymph
 Muscle Antibodies  >231 publications with MBP  and Muscle
 Spleen Antibodies  >231 publications with MBP  and Spleen
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