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anti-MCM2 antibody :: Rabbit anti-Human, mouse MCM2 Antibody

Scan QR to view Datasheet Catalog #    MBS000173 anti-MCM2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MCM2, Antibody

 Also Known As   

Rabbit MCM2 Antibody

 Product Gene Name   

anti-MCM2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (127317253..127341279). Location: 3q21
 OMIM    116945
 3D Structure    ModBase 3D Structure for P49736
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-MCM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MCM2 antibody   

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MCM2. It may not necessarily be applicable to this product.
 NCBI GI #    33356547
 NCBI GeneID    4171
 NCBI Accession #    NP_004517.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004526.3 [Other Products]
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 UniProt Primary Accession #    P49736 [Other Products]
 UniProt Secondary Accession #    Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7 [Other Products]
 UniProt Related Accession #    P49736 [Other Products]
 Molecular Weight    101,896 Da
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 NCBI Official Full Name    DNA replication licensing factor MCM2
 NCBI Official Synonym Full Names    minichromosome maintenance complex component 2
 NCBI Official Symbol    MCM2 [Similar Products]
 NCBI Official Synonym Symbols   
BM28; CCNL1; CDCL1; cdc19; D3S3194; MITOTIN
[Similar Products]
 NCBI Protein Information    DNA replication licensing factor MCM2; cyclin-like 1; nuclear protein BM28; cell devision cycle-like 1; minichromosome maintenance protein 2 homolog; minichromosome maintenance deficient 2 (mitotin); MCM2 minichromosome maintenance deficient 2, mitotin
 UniProt Protein Name    DNA replication licensing factor MCM2
 UniProt Synonym Protein Names   
Minichromosome maintenance protein 2 homolog; Nuclear protein BM28
 Protein Family    DNA replication licensing factor
 UniProt Gene Name    MCM2 [Similar Products]
 UniProt Synonym Gene Names    BM28; CCNL1; CDCL1; KIAA0030 [Similar Products]
 UniProt Entry Name    MCM2_HUMAN
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 NCBI Summary for MCM2    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
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 UniProt Comments for MCM2    MCM2: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

Protein type: DNA-binding; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: microtubule cytoskeleton; nucleoplasm; MCM complex; cytoplasm; chromatin; nuclear origin of replication recognition complex; nucleus

Molecular Function: protein binding; DNA helicase activity; DNA binding; histone binding; metal ion binding; DNA replication origin binding; ATP binding

Biological Process: DNA unwinding during replication; nucleosome assembly; DNA replication initiation; DNA strand elongation during DNA replication; mitotic cell cycle; cell cycle; DNA replication; G1/S transition of mitotic cell cycle
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 Research Articles on MCM2    1. Immunohistochemical expression of minichromosome maintenance complex protein 2 predicts biochemical recurrence in prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MCM2 antibodyPathways associated with anti-MCM2 antibody
 Reference Product  PubMed Publications
 CDC6 antibody  >106 publications with MCM2 and CDC6
 MCM7 antibody  >99 publications with MCM2 and MCM7
 MCM4 antibody  >95 publications with MCM2 and MCM4
 MCM5 antibody  >88 publications with MCM2 and MCM5
 MCM3 antibody  >88 publications with MCM2 and MCM3
 MCM6 antibody  >77 publications with MCM2 and MCM6
 CDC7 antibody  >63 publications with MCM2 and CDC7
 DBF4 antibody  >41 publications with MCM2 and DBF4
 MCM10 antibody  >39 publications with MCM2 and MCM10
 ORC2 antibody  >18 publications with MCM2 and ORC2
 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Assembly Of The Pre-replicative Complex Pathway antibodies  Assembly Of The Pre-replicative Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
Diseases associated with anti-MCM2 antibodyOrgans/Tissues associated with anti-MCM2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >225 publications with MCM2 and Neoplasms
 Carcinoma Antibodies  >132 publications with MCM2 and Carcinoma
 Adenocarcinoma Antibodies  >55 publications with MCM2 and Adenocarcinoma
 Uterine Cervical Neoplasms Antibodies  >29 publications with MCM2 and Uterine Cervical Neoplasms
 Precancerous Conditions Antibodies  >23 publications with MCM2 and Precancerous Conditions
 Nervous System Diseases Antibodies  >19 publications with MCM2 and Nervous System Diseases
 Breast Neoplasms Antibodies  >18 publications with MCM2 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >17 publications with MCM2 and Cell Transformation, Neoplastic
 Brain Diseases Antibodies  >15 publications with MCM2 and Brain Diseases
 Neoplasms, Experimental Antibodies  >14 publications with MCM2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >26 publications with MCM2 and Brain
 Blood Antibodies  >24 publications with MCM2 and Blood
 Lymph Node Antibodies  >22 publications with MCM2 and Lymph Node
 Lymph Antibodies  >22 publications with MCM2 and Lymph
 Lung Antibodies  >20 publications with MCM2 and Lung
 Liver Antibodies  >16 publications with MCM2 and Liver
 Cervix Antibodies  >14 publications with MCM2 and Cervix
 Bone Antibodies  >14 publications with MCM2 and Bone
 Prostate Antibodies  >12 publications with MCM2 and Prostate
 Mouth Antibodies  >10 publications with MCM2 and Mouth
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