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anti-MEF2C antibody :: Rabbit anti-Human, mouse MEF2C Antibody

Scan QR to view Datasheet Catalog #    MBS001080 anti-MEF2C antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MEF2C, Antibody

 Also Known As   

Rabbit MEF2C Antibody

 Product Gene Name   

anti-MEF2C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (88014058..88199922, complement). Location: 5q14
 OMIM    600662
 3D Structure    ModBase 3D Structure for Q06413
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-MEF2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MEF2C antibody   

Immunohistochemistry (IHC), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for MEF2C. It may not necessarily be applicable to this product.
 NCBI GI #    196114945
 NCBI GeneID    4208
 NCBI Accession #    NP_001124477.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001131005.2 [Other Products]
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 UniProt Primary Accession #    Q06413 [Other Products]
 UniProt Secondary Accession #    C9JMZ0; D7F7N5; F8W7V7 [Other Products]
 UniProt Related Accession #    Q06413 [Other Products]
 Molecular Weight    51,221 Da
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 NCBI Official Full Name    myocyte-specific enhancer factor 2C isoform 2
 NCBI Official Synonym Full Names    myocyte enhancer factor 2C
 NCBI Official Symbol    MEF2C [Similar Products]
 NCBI Official Synonym Symbols   
DEL5q14.3; C5DELq14.3
[Similar Products]
 NCBI Protein Information    myocyte-specific enhancer factor 2C; MADS box transcription enhancer factor 2, polypeptide C
 UniProt Protein Name    Myocyte-specific enhancer factor 2C
 Protein Family    Myocyte-specific enhancer factor
 UniProt Gene Name    MEF2C [Similar Products]
 UniProt Entry Name    MEF2C_HUMAN
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 NCBI Summary for MEF2C    This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
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 UniProt Comments for MEF2C    MEF2C: transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5q14.3

Cellular Component: nucleoplasm; protein complex; intracellular membrane-bound organelle; cytoplasm; nuclear speck; nucleus; cytosol

Molecular Function: protein binding; miRNA binding; transcription activator binding; DNA binding; AT DNA binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity

Biological Process: cardiac muscle hypertrophy; muscle development; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; heart development; regulation of neurotransmitter secretion; stress-activated MAPK cascade; regulation of synaptic plasticity; toll-like receptor 3 signaling pathway; toll-like receptor 5 signaling pathway; neuron differentiation; positive regulation of MAP kinase activity; B cell receptor signaling pathway; regulation of neuron apoptosis; negative regulation of ossification; positive regulation of B cell proliferation; chondrocyte differentiation; negative regulation of neuron apoptosis; toll-like receptor 4 signaling pathway; positive regulation of cardiac muscle cell proliferation; endochondral ossification; nervous system development; skeletal muscle development; monocyte differentiation; response to virus; myotube differentiation; positive regulation of skeletal muscle development; muscle cell fate determination; toll-like receptor 2 signaling pathway; muscle cell differentiation; regulation of synaptogenesis; neuron development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; toll-like receptor 9 signaling pathway; B cell proliferation; transcription from RNA polymerase II promoter; regulation of synaptic transmission, glutamatergic; apoptosis; neuron migration; ventricular cardiac muscle cell differentiation; regulation of synaptic activity; negative regulation of transcription from RNA polymerase II promoter; palate development; toll-like receptor 10 signaling pathway; learning and/or memory; B cell homeostasis; regulation of transcription, DNA-dependent; melanocyte differentiation; regulation of megakaryocyte differentiation; germinal center formation; neural crest cell differentiation; heart looping; negative regulation of epithelial cell proliferation; blood vessel development; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; embryonic viscerocranium morphogenesis; positive regulation of bone mineralization; humoral immune response; regulation of germinal center formation; positive regulation of myoblast differentiation; osteoblast differentiation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of osteoblast differentiation; neuron morphogenesis during differentiation; toll-like receptor signaling pathway; innate immune response; positive regulation of muscle cell differentiation; blood vessel remodeling; platelet formation; regulation of excitatory postsynaptic membrane potential; positive regulation of neuron differentiation

Disease: Mental Retardation, Autosomal Dominant 20
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 Research Articles on MEF2C    1. genetic association study in population of 1,012 Han women in China: Data suggest that an SNP in MEF2C (rs1366594) is associated with bone mineral density of lumbar spine and hip joint in aging women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MEF2C antibodyPathways associated with anti-MEF2C antibody
 Reference Product  PubMed Publications
 GATA4 antibody  >94 publications with MEF2C and GATA4
 MEF2D antibody  >44 publications with MEF2C and MEF2D
 HDAC5 antibody  >25 publications with MEF2C and HDAC5
 HDAC4 antibody  >21 publications with MEF2C and HDAC4
 NOTCH1 antibody  >5 publications with MEF2C and NOTCH1
 SP1 antibody  >5 publications with MEF2C and SP1
 NCOA2 antibody  >3 publications with MEF2C and NCOA2
 SOX18 antibody  >3 publications with MEF2C and SOX18
 MAPK14 antibody  >2 publications with MEF2C and MAPK14
 TEAD1 antibody  >2 publications with MEF2C and TEAD1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ERK/MAPK Targets Pathway antibodies  ERK/MAPK Targets Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
Diseases associated with anti-MEF2C antibodyOrgans/Tissues associated with anti-MEF2C antibody
 Disease Name  Pubmed Publications
 Hypertrophy Antibodies  >44 publications with MEF2C and Hypertrophy
 Nervous System Diseases Antibodies  >39 publications with MEF2C and Nervous System Diseases
 Neoplasms Antibodies  >37 publications with MEF2C and Neoplasms
 Intellectual Disability Antibodies  >19 publications with MEF2C and Intellectual Disability
 Disease Models, Animal Antibodies  >17 publications with MEF2C and Disease Models, Animal
 Brain Diseases Antibodies  >17 publications with MEF2C and Brain Diseases
 Fibrosis Antibodies  >15 publications with MEF2C and Fibrosis
 Epilepsy Antibodies  >12 publications with MEF2C and Epilepsy
 Necrosis Antibodies  >10 publications with MEF2C and Necrosis
 Inflammation Antibodies  >7 publications with MEF2C and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >318 publications with MEF2C and Muscle
 Heart Antibodies  >229 publications with MEF2C and Heart
 Embryonic Tissue Antibodies  >105 publications with MEF2C and Embryonic Tissue
 Brain Antibodies  >64 publications with MEF2C and Brain
 Vascular Antibodies  >50 publications with MEF2C and Vascular
 Blood Antibodies  >48 publications with MEF2C and Blood
 Bone Marrow Antibodies  >36 publications with MEF2C and Bone Marrow
 Nerve Antibodies  >17 publications with MEF2C and Nerve
 Connective Tissue Antibodies  >16 publications with MEF2C and Connective Tissue
 Liver Antibodies  >11 publications with MEF2C and Liver
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