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anti-MEK1 antibody :: Rabbit MEK1 (Phospho-Thr291) Antibody

Scan QR to view Datasheet Catalog #    MBS004798 anti-MEK1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MEK1 (Phospho-Thr291), Antibody

 Also Known As   

Rabbit MEK1 (Phospho-Thr291) Antibody

 Product Gene Name   

anti-MEK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 15; NC_000015.9 (66679211..66783882). Location: 15q22.1-q22.33
 OMIM    115150
 3D Structure    ModBase 3D Structure for Q02750
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-MEK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MEK1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MEK1. It may not necessarily be applicable to this product.
 NCBI GI #    5579478
 NCBI GeneID    5604
 NCBI Accession #    NP_002746.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002755.3 [Other Products]
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 UniProt Primary Accession #    Q02750 [Other Products]
 UniProt Related Accession #    Q02750 [Other Products]
 Molecular Weight    43,439 Da
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 NCBI Official Full Name    dual specificity mitogen-activated protein kinase kinase 1
 NCBI Official Synonym Full Names    mitogen-activated protein kinase kinase 1
 NCBI Official Symbol    MAP2K1 [Similar Products]
 NCBI Official Synonym Symbols   
MEK1; MKK1; MAPKK1; PRKMK1
[Similar Products]
 NCBI Protein Information    dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
 UniProt Protein Name    Dual specificity mitogen-activated protein kinase kinase 1
 UniProt Synonym Protein Names   
ERK activator kinase 1; MAPK/ERK kinase 1
 Protein Family    Meiosis-specific serine/threonine-protein kinase
 UniProt Gene Name    MAP2K1 [Similar Products]
 UniProt Synonym Gene Names    MEK1; PRKMK1; MAP kinase kinase 1; MAPKK 1; MKK1; MEK 1 [Similar Products]
 UniProt Entry Name    MP2K1_HUMAN
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 NCBI Summary for MEK1    The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MEK1    MEK1: a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf, Mos and Cot kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK1 and ERK2. An essential component of MAP kinase signal transduction pathways involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Protein type: Protein kinase, dual-specificity (non-receptor); EC 2.7.12.2; Protein kinase, STE; Kinase, protein; STE group; STE7 family

Chromosomal Location of Human Ortholog: 15q22.1-q22.33

Cellular Component: dendrite cytoplasm; Golgi apparatus; microtubule; focal adhesion; mitochondrion; endoplasmic reticulum; early endosome; perikaryon; cell cortex; cytosol; perinuclear region of cytoplasm; axon; cytoplasm; late endosome; plasma membrane; microtubule organizing center; nucleus

Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; Ras GTPase binding; receptor signaling protein tyrosine phosphatase activity; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; mitogen-activated protein kinase kinase kinase binding; ATP binding; protein kinase activity

Biological Process: axon guidance; peptidyl-tyrosine phosphorylation; activation of MAPKK activity; nerve growth factor receptor signaling pathway; protein heterooligomerization; activation of MAPK activity; negative regulation of homotypic cell-cell adhesion; response to glucocorticoid stimulus; cell motility involved in cell locomotion; stress-activated MAPK cascade; pathogenesis; toll-like receptor 3 signaling pathway; chemotaxis; signal transduction; toll-like receptor 10 signaling pathway; neuron differentiation; toll-like receptor 5 signaling pathway; negative regulation of cell proliferation; positive regulation of RNA elongation from RNA polymerase II promoter; small GTPase mediated signal transduction; vesicle transport along microtubule; response to axon injury; cell cycle arrest; toll-like receptor 4 signaling pathway; Golgi inheritance; epidermal growth factor receptor signaling pathway; mitosis; fibroblast growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; melanosome transport; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; keratinocyte differentiation; cell proliferation; regulation of stress-activated MAPK cascade; Ras protein signal transduction; regulation of vascular smooth muscle contraction; toll-like receptor signaling pathway; insulin receptor signaling pathway; innate immune response; positive regulation of Ras protein signal transduction; response to oxidative stress; toll-like receptor 9 signaling pathway; vascular endothelial growth factor receptor signaling pathway; cell motility; positive regulation of cell differentiation; positive regulation of cell migration

Disease: Noonan Syndrome 1; Cardiofaciocutaneous Syndrome 3
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 Research Articles on MEK1    1. osteosarcoma patients whose tumors expressed pMEK1 had a poorer clinical outcome than those whose tumors did not.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MEK1 antibodyPathways associated with anti-MEK1 antibody
 Reference Product  PubMed Publications
 MAPK1 antibody  >385 publications with MEK1 and MAPK1
 MAPK3 antibody  >353 publications with MEK1 and MAPK3
 BRAF antibody  >89 publications with MEK1 and BRAF
 EGFR antibody  >39 publications with MEK1 and EGFR
 HRAS antibody  >38 publications with MEK1 and HRAS
 RAF1 antibody  >35 publications with MEK1 and RAF1
 MAP3K1 antibody  >28 publications with MEK1 and MAP3K1
 MYC antibody  >24 publications with MEK1 and MYC
 ELK1 antibody  >18 publications with MEK1 and ELK1
 PAK1 antibody  >15 publications with MEK1 and PAK1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
Diseases associated with anti-MEK1 antibodyOrgans/Tissues associated with anti-MEK1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >375 publications with MEK1 and Neoplasms
 Necrosis Antibodies  >93 publications with MEK1 and Necrosis
 Cardiovascular Diseases Antibodies  >68 publications with MEK1 and Cardiovascular Diseases
 Inflammation Antibodies  >58 publications with MEK1 and Inflammation
 Breast Neoplasms Antibodies  >49 publications with MEK1 and Breast Neoplasms
 Heart Diseases Antibodies  >41 publications with MEK1 and Heart Diseases
 Melanoma Antibodies  >40 publications with MEK1 and Melanoma
 Nervous System Diseases Antibodies  >39 publications with MEK1 and Nervous System Diseases
 Drug Toxicity Antibodies  >32 publications with MEK1 and Drug Toxicity
 Neoplasm Invasiveness Antibodies  >31 publications with MEK1 and Neoplasm Invasiveness
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >197 publications with MEK1 and Blood
 Vascular Antibodies  >84 publications with MEK1 and Vascular
 Muscle Antibodies  >78 publications with MEK1 and Muscle
 Lung Antibodies  >74 publications with MEK1 and Lung
 Brain Antibodies  >69 publications with MEK1 and Brain
 Heart Antibodies  >55 publications with MEK1 and Heart
 Skin Antibodies  >52 publications with MEK1 and Skin
 Bone Antibodies  >48 publications with MEK1 and Bone
 Kidney Antibodies  >46 publications with MEK1 and Kidney
 Nerve Antibodies  >40 publications with MEK1 and Nerve
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