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anti-MER/SKY antibody :: MER/SKY Antibody

Scan QR to view Datasheet Catalog #    MBS853167
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MER/SKY, Antibody

★Popular Item★
 Also Known As   

MER/SKY (Phospho-Tyr749/681) Antibody

 Product Synonym Names    C-mer; EC 2.7.10.1; kinase Mer; MERK; MERTK; proto-oncogene tyrosine-protein kinase MER precursor; receptor tyrosine kinase MerTK
 Product Gene Name   

anti-MER/SKY antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604705
 3D Structure    ModBase 3D Structure for Q12866
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    MER/SKY (Phospho-Tyr749/681) antibody detects endogenous levels of MER/SKY only when phosphorylated at tyrosine 749/681.
 Purity/Purification    Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human MER/SKY around the phosphorylation site of tyrosine 749/681 (K-I-YP-S-G).
 All Sites    Human: Tyr749/681
Mouse: Tyr744/671
Rat: Tyr744/671
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-MER/SKY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MER/SKY antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-MER/SKY antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-MER/SKY antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000
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 Testing Data of anti-MER/SKY antibody    P-peptide-+
anti-MER/SKY antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-MER/SKY antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using MER/SKY (Phospho-Tyr749/681) antibody. Western blot analysis of extracts from 3T3 cells, treated with EGF (200ng/ml, 5mins), using MER/SKY (Phospho-Tyr749/681) antibody.
anti-MER/SKY antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MER/SKY. It may not necessarily be applicable to this product.
 NCBI GI #    66932918
 NCBI GeneID    10461
 NCBI Accession #    NP_006334.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006343.2 [Other Products]
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 UniProt Primary Accession #    Q12866 [Other Products]
 UniProt Secondary Accession #    Q9HBB4 [Other Products]
 UniProt Related Accession #    Q12866 [Other Products]
 Molecular Weight    110,249 Da
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 NCBI Official Full Name    tyrosine-protein kinase Mer
 NCBI Official Synonym Full Names    MER proto-oncogene, tyrosine kinase
 NCBI Official Symbol    MERTK [Similar Products]
 NCBI Official Synonym Symbols   
MER; RP38; c-Eyk; c-mer; Tyro12
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase Mer
 UniProt Protein Name    Tyrosine-protein kinase Mer
 UniProt Synonym Protein Names   
Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
 UniProt Gene Name    MERTK [Similar Products]
 UniProt Synonym Gene Names    MER [Similar Products]
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 NCBI Summary for MER/SKY    This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]
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 UniProt Comments for MER/SKY    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
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Product References and Citations for anti-MER/SKY antibody

   Graham D.K., Cell Growth Differ. 5:647-657(1994). Gal A., Nat. Genet. 26:270-271(2000). Hillier L.W., Nature 434:724-731(2005).
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 Research Articles on MER/SKY    1. Study describes a novel cellular pathway involved in diabetic efferocytosis, wherein diabetes-induced decrease in miR-126 expression results in upregulation of ADAM9 expression that in-turn leads proteolytic cleavage of MerTK and formation of inactive soluble Mer. Decrease in MerTK phosphorylation leads to reduced downstream cytoskeletal signaling required for engulfment and thus decreases efferocytosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MER/SKY antibodyPathways associated with anti-MER/SKY antibody
 Reference Product  PubMed Publications
 GAS6 antibody  >55 publications with MER/SKY and GAS6
 GRB2 antibody  >3 publications with MER/SKY and GRB2
 VAV1 antibody  >2 publications with MER/SKY and VAV1
 TNK2 antibody  >2 publications with MER/SKY and TNK2
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-MER/SKY antibodyOrgans/Tissues associated with anti-MER/SKY antibody
 Disease Name  Pubmed Publications
 Retinitis Pigmentosa Antibodies  >38 publications with MER/SKY and Retinitis Pigmentosa
 Neoplasms Antibodies  >36 publications with MER/SKY and Neoplasms
 Inflammation Antibodies  >31 publications with MER/SKY and Inflammation
 Disease Models, Animal Antibodies  >27 publications with MER/SKY and Disease Models, Animal
 Nervous System Diseases Antibodies  >20 publications with MER/SKY and Nervous System Diseases
 Death Antibodies  >20 publications with MER/SKY and Death
 Necrosis Antibodies  >19 publications with MER/SKY and Necrosis
 Atherosclerosis Antibodies  >13 publications with MER/SKY and Atherosclerosis
 Nerve Degeneration Antibodies  >10 publications with MER/SKY and Nerve Degeneration
 Brain Diseases Antibodies  >9 publications with MER/SKY and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >78 publications with MER/SKY and Eye
 Blood Antibodies  >63 publications with MER/SKY and Blood
 Bone Antibodies  >23 publications with MER/SKY and Bone
 Brain Antibodies  >16 publications with MER/SKY and Brain
 Lung Antibodies  >10 publications with MER/SKY and Lung
 Testis Antibodies  >10 publications with MER/SKY and Testis
 Kidney Antibodies  >7 publications with MER/SKY and Kidney
 Liver Antibodies  >6 publications with MER/SKY and Liver
 Muscle Antibodies  >6 publications with MER/SKY and Muscle
 Embryonic Tissue Antibodies  >5 publications with MER/SKY and Embryonic Tissue
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