NP_001159815.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,666 Da
NCBI Official Full Name
beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform 2
NCBI Official Synonym Full Names
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
NCBI Protein Information
beta-1,3-N-acetylglucosaminyltransferase manic fringe
UniProt Protein Name
Beta-1,3-N-acetylglucosaminyltransferase manic fringe
UniProt Synonym Protein Names
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
NCBI Summary for MFNG
This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the LFNG (GeneID: 3955) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene may control Notch signaling in claudin-low breast cancer. [provided by RefSeq, May 2018]
UniProt Comments for MFNG
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 ().
Product References and Citations for anti-MFNG antibody
Johnston S.H., Development 124:2245-2254(1997). Collins J.E., Genome Biol. 5:R84.1-R84.11(2004). Dunham I., Nature 402:489-495(1999).
Research Articles on MFNG
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Products associated with anti-MFNG antibody
Pathways associated with anti-MFNG antibody
Diseases associated with anti-MFNG antibody
Organs/Tissues associated with anti-MFNG antibody
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