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anti-MITF antibody :: Rabbit anti-Human, Mouse MITF Antibody

Scan QR to view Datasheet Catalog #    MBS853726
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MITF, Antibody

 Also Known As   

MITF (Ab-180/73) Antibody

 Product Synonym Names    MITF M1; Microphthalmia-associated transcription factor
 Product Gene Name   

anti-MITF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614456
 3D Structure    ModBase 3D Structure for O75030
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 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    MITF (Ab-180/73) antibody detects endogenous levels of total MITF protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human MITF around the phosphorylation site of serine 180/73 (P-N-SP-P-M).
 Pathway    Transcription
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-MITF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MITF antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-MITF antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-MITF antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:10000
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 Testing Data of anti-MITF antibody    anti-MITF antibody Testing Data image
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 Testing Data #2 of anti-MITF antibody    Immunohistochemistry analysis of paraffin-embedded human skin tissue using MITF (Ab-180/73) antibody.
Western blot analysis of extracts from HepG2 cells (lane 1) and COLO205 cells (lane 2), using MITF (Ab-180/73) antibody.
anti-MITF antibody Testing Data #2 image
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 Testing Data #3 of anti-MITF antibody    Peptide - +
Immunofluorescence analysis of HeLa cells, using MITF (Ab-180/73) antibody.
anti-MITF antibody Testing Data #3 image
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NCBI/Uniprot data below describe general gene information for MITF. It may not necessarily be applicable to this product.
 NCBI GI #    4557755
 NCBI GeneID    4286
 NCBI Accession #    NP_000239.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000248.3 [Other Products]
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 UniProt Primary Accession #    O75030 [Other Products]
 UniProt Secondary Accession #    Q14841; Q9P2V0; Q9P2V1; Q9P2V2; Q9P2Y8; B4DJL2; D3K197; E9PFN0 [Other Products]
 UniProt Related Accession #    O75030 [Other Products]
 Molecular Weight    52,527 Da
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 NCBI Official Full Name    microphthalmia-associated transcription factor isoform 4
 NCBI Official Synonym Full Names    microphthalmia-associated transcription factor
 NCBI Official Symbol    MITF [Similar Products]
 NCBI Official Synonym Symbols   
MI; WS2; CMM8; WS2A; bHLHe32
[Similar Products]
 NCBI Protein Information    microphthalmia-associated transcription factor; class E basic helix-loop-helix protein 32
 UniProt Protein Name    Microphthalmia-associated transcription factor
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 32; bHLHe32
 Protein Family    Microphthalmia-associated transcription factor
 UniProt Gene Name    MITF [Similar Products]
 UniProt Synonym Gene Names    BHLHE32; bHLHe32 [Similar Products]
 UniProt Entry Name    MITF_HUMAN
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 NCBI Summary for MITF    This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MITF    MITF: a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. Plays a critical role in the differentiation of various cell types including neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Two isoforms are known: the M-isoform is expressed exclusively in melanocytes, while the A-isoform has a much broader range of expression. Mutations in MITF can lead to Waardenburg syndrome. Ten alternatively spliced isoforms have been described.

Protein type: Transcription factor; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 3p14.2-p14.1

Cellular Component: protein complex; nucleus

Molecular Function: protein dimerization activity; RNA polymerase II transcription factor activity, enhancer binding; protein binding; chromatin binding

Biological Process: transcription from RNA polymerase II promoter; camera-type eye development; cell fate commitment; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; bone remodeling; regulation of cell proliferation; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; melanocyte differentiation; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter

Disease: Albinism, Ocular, With Sensorineural Deafness; Waardenburg Syndrome, Type 2a; Melanoma, Cutaneous Malignant, Susceptibility To, 8; Tietz Syndrome
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Product References and Citations for anti-MITF antibody

   Jn H. Hallsson, Genetics, May 2004; 167: 233 - 241.
Eiichi Morii, Blood, Apr 2001; 97: 2038 - 2044.
Eiichi Morii, Blood, Sep 2004; 104: 1656 - 1661.
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 Research Articles on MITF    1. Both MITF-1 and SOX10 can be used to differentiate melanoma in situ from actinic keratosis with melanocytic hyperplasia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MITF antibodyPathways associated with anti-MITF antibody
 Reference Product  PubMed Publications
 SOX10 antibody  >93 publications with MITF and SOX10
 PAX3 antibody  >92 publications with MITF and PAX3
 CTNNB1 antibody  >69 publications with MITF and CTNNB1
 PAX6 antibody  >35 publications with MITF and PAX6
 LEF1 antibody  >13 publications with MITF and LEF1
 PIAS3 antibody  >12 publications with MITF and PIAS3
 MAPK14 antibody  >2 publications with MITF and MAPK14
 MARK3 antibody  >1 publications with MITF and MARK3
 SUMO1 antibody  >1 publications with MITF and SUMO1
 Products by Pathway  Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Melanoma Pathway antibodies  Melanoma Pathway Diagram
 Melanoma Pathway antibodies  Melanoma Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
Diseases associated with anti-MITF antibodyOrgans/Tissues associated with anti-MITF antibody
 Disease Name  Pubmed Publications
 Skin Neoplasms Antibodies  >187 publications with MITF and Skin Neoplasms
 Neoplasms, Experimental Antibodies  >134 publications with MITF and Neoplasms, Experimental
 Pigmentation Disorders Antibodies  >119 publications with MITF and Pigmentation Disorders
 Deafness Antibodies  >59 publications with MITF and Deafness
 Carcinoma, Renal Cell Antibodies  >43 publications with MITF and Carcinoma, Renal Cell
 Inflammation Antibodies  >41 publications with MITF and Inflammation
 Kidney Diseases Antibodies  >41 publications with MITF and Kidney Diseases
 Waardenburg syndrome type 2 Antibodies  >30 publications with MITF and Waardenburg syndrome type 2
 Necrosis Antibodies  >29 publications with MITF and Necrosis
 Tietz syndrome Antibodies  >15 publications with MITF and Tietz syndrome
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >502 publications with MITF and Skin
 Eye Antibodies  >177 publications with MITF and Eye
 Bone Antibodies  >131 publications with MITF and Bone
 Blood Antibodies  >122 publications with MITF and Blood
 Muscle Antibodies  >62 publications with MITF and Muscle
 Embryonic Tissue Antibodies  >62 publications with MITF and Embryonic Tissue
 Kidney Antibodies  >49 publications with MITF and Kidney
 Brain Antibodies  >32 publications with MITF and Brain
 Lung Antibodies  >31 publications with MITF and Lung
 Connective Tissue Antibodies  >27 publications with MITF and Connective Tissue
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