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anti-MRC1 antibody :: Rabbit MRC1 Antibody

Scan QR to view Datasheet Catalog #    MBS855077
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MRC1, Antibody

 Also Known As   

MRC1 Antibody

 Product Synonym Names    Macrophage mannose receptor 1; MMR; CD206 antigen
 Product Gene Name   

anti-MRC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    153618
 3D Structure    ModBase 3D Structure for P22897
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    MRC1 antibody detects endogenous levels of total MRC1 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
 Swiss-Prot No.    P22897
 Immunogen    The antiserum was produced against synthesized peptide CLYAKGKHEKKTWFE derived from internal of human MRC1.
 Pathway    Lymphocyte Signaling
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-MRC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MRC1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-MRC1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-MRC1 antibody    WB: 1:500~1:1000, ELISA: 1:20000
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 Testing Data of anti-MRC1 antibody    Western blot analysis of extracts from K562 cells, A549 cells and NIH-3T3 cells, using MRC1 antibody.
For Research Use Only
anti-MRC1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for MRC1. It may not necessarily be applicable to this product.
 NCBI GI #    4505245
 NCBI GeneID    4360
 NCBI Accession #    NP_002429.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002438.3 [Other Products]
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 UniProt Primary Accession #    P22897 [Other Products]
 UniProt Secondary Accession #    Q5VSJ2; Q5VSK2; A5PKW3 [Other Products]
 UniProt Related Accession #    P22897 [Other Products]
 Molecular Weight    56,554 Da
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 NCBI Official Full Name    macrophage mannose receptor 1
 NCBI Official Synonym Full Names    mannose receptor, C type 1
 NCBI Official Symbol    MRC1 [Similar Products]
 NCBI Official Synonym Symbols   
MMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1
[Similar Products]
 NCBI Protein Information    macrophage mannose receptor 1; mannose receptor, C type 1-like 1; C-type lectin domain family 13 member D; macrophage mannose receptor 1-like protein 1
 UniProt Protein Name    Macrophage mannose receptor 1
 UniProt Synonym Protein Names   
C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1; CD_antigen: CD206
 Protein Family    Macrophage mannose receptor
 UniProt Gene Name    MRC1 [Similar Products]
 UniProt Synonym Gene Names    CLEC13D; CLEC13DL; MRC1L1; MMR [Similar Products]
 UniProt Entry Name    MRC1_HUMAN
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 NCBI Summary for MRC1    The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Apr 2011]
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 UniProt Comments for MRC1    MRC1: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 10p12.33

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; endosome membrane

Molecular Function: mannose binding; protein binding; transmembrane receptor activity; receptor activity

Biological Process: receptor-mediated endocytosis; signal transduction
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Product References and Citations for anti-MRC1 antibody

   Taylor M.E., J. Biol. Chem. 265:12156-12162(1990).
Ezekowitz R.A., J. Exp. Med. 172:1785-1794(1990).
Kim S.J., Genomics 14:721-727(1992).
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 Research Articles on MRC1    1. presence of soluble form of MR in human serum in critical illness
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MRC1 antibodyPathways associated with anti-MRC1 antibody
 Reference Product  PubMed Publications
 CD163 antibody  >7 publications with MRC1 and CD163
 CHEK2 antibody  >3 publications with MRC1 and CHEK2
 ITGAM antibody  >2 publications with MRC1 and ITGAM
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway antibodies  Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
Diseases associated with anti-MRC1 antibodyOrgans/Tissues associated with anti-MRC1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >15 publications with MRC1 and Inflammation
 Lung Diseases Antibodies  >7 publications with MRC1 and Lung Diseases
 Necrosis Antibodies  >6 publications with MRC1 and Necrosis
 Disease Models, Animal Antibodies  >3 publications with MRC1 and Disease Models, Animal
 Weight Loss Antibodies  >3 publications with MRC1 and Weight Loss
 Acute Kidney Injury Antibodies  >1 publications with MRC1 and Acute Kidney Injury
 Liver Diseases Antibodies  >1 publications with MRC1 and Liver Diseases
 Cognition Disorders Antibodies  >1 publications with MRC1 and Cognition Disorders
 Fibrosis Antibodies  >1 publications with MRC1 and Fibrosis
 Edema Antibodies  >1 publications with MRC1 and Edema
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with MRC1 and Blood
 Brain Antibodies  >8 publications with MRC1 and Brain
 Lung Antibodies  >4 publications with MRC1 and Lung
 Spleen Antibodies  >4 publications with MRC1 and Spleen
 Connective Tissue Antibodies  >3 publications with MRC1 and Connective Tissue
 Placenta Antibodies  >1 publications with MRC1 and Placenta
 Uterus Antibodies  >1 publications with MRC1 and Uterus
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