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anti-MRE11 antibody :: Rabbit MRE11 (Ab-264) Antibody

Scan QR to view Datasheet Catalog #    MBS004054 anti-MRE11 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MRE11 (Ab-264), Antibody

 Also Known As   

Rabbit MRE11 (Ab-264) Antibody

 Product Gene Name   

anti-MRE11 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (94150466..94227040, complement). Location: 11q21
 OMIM    600814
 3D Structure    ModBase 3D Structure for P49959
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-MRE11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MRE11 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MRE11. It may not necessarily be applicable to this product.
 NCBI GI #    24234690
 NCBI GeneID    4361
 NCBI Accession #    NP_005581.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005590.3 [Other Products]
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 UniProt Primary Accession #    P49959 [Other Products]
 UniProt Secondary Accession #    O43475 [Other Products]
 UniProt Related Accession #    P49959 [Other Products]
 Molecular Weight    80,593 Da
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 NCBI Official Full Name    double-strand break repair protein MRE11A isoform 2
 NCBI Official Synonym Full Names    MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
 NCBI Official Symbol    MRE11A [Similar Products]
 NCBI Official Synonym Symbols   
ATLD; HNGS1; MRE11; MRE11B
[Similar Products]
 NCBI Protein Information    double-strand break repair protein MRE11A; AT-like disease; MRE11 homolog 1; MRE11 homolog A; endo/exonuclease Mre11; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; DNA recombination and repair protein
 UniProt Protein Name    Double-strand break repair protein MRE11A
 UniProt Synonym Protein Names   
Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A
 Protein Family    Double-strand break repair protein
 UniProt Gene Name    MRE11A [Similar Products]
 UniProt Synonym Gene Names    HNGS1; MRE11; MRE11 homolog 1 [Similar Products]
 UniProt Entry Name    MRE11_HUMAN
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 NCBI Summary for MRE11    This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MRE11    MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.

Protein type: DNA-binding; Cell cycle regulation; Deoxyribonuclease; DNA repair, damage

Chromosomal Location of Human Ortholog: 11q21

Cellular Component: nucleoplasm; chromosome, telomeric region; Mre11 complex; nucleus; cytosol; chromatin

Molecular Function: protein C-terminus binding; ATP-dependent DNA helicase activity; protein binding; nuclease activity; DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; endonuclease activity; manganese ion binding; double-stranded DNA binding; 3'-5' exonuclease activity; endodeoxyribonuclease activity

Biological Process: sister chromatid cohesion; positive regulation of kinase activity; negative regulation of DNA endoreduplication; telomere maintenance via telomerase; regulation of mitotic recombination; DNA repair; DNA catabolic process, endonucleolytic; positive regulation of protein amino acid autophosphorylation; double-strand break repair via homologous recombination; DNA duplex unwinding; double-strand break repair via nonhomologous end joining; DNA recombination; cell proliferation; intra-S DNA damage checkpoint; nucleotide-excision repair; base-excision repair; meiotic recombination; mitotic cell cycle G2/M transition DNA damage checkpoint; double-strand break repair; synapsis; positive regulation of interferon type I production; innate immune response; telomere maintenance; response to DNA damage stimulus

Disease: Ataxia-telangiectasia-like Disorder 1
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 Research Articles on MRE11    1. TIS21 regulates DNA double strand break repair and apoptosis via increasing Mre11 methylation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MRE11 antibodyPathways associated with anti-MRE11 antibody
 Reference Product  PubMed Publications
 RAD50 antibody  >274 publications with MRE11 and RAD50
 NBN antibody  >194 publications with MRE11 and NBN
 ATM antibody  >149 publications with MRE11 and ATM
 H2AFX antibody  >41 publications with MRE11 and H2AFX
 TP53 antibody  >12 publications with MRE11 and TP53
 FANCD2 antibody  >7 publications with MRE11 and FANCD2
 DCLRE1C antibody  >5 publications with MRE11 and DCLRE1C
 XRCC6 antibody  >2 publications with MRE11 and XRCC6
 Products by Pathway  Pathway Diagram
 Assembly Of The RAD50-MRE11-NBS1 Complex At DNA Double-strand Breaks Pathway antibodies  Assembly Of The RAD50-MRE11-NBS1 Complex At DNA Double-strand Breaks Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 Homologous Recombination Repair Pathway antibodies  Homologous Recombination Repair Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
Diseases associated with anti-MRE11 antibodyOrgans/Tissues associated with anti-MRE11 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >110 publications with MRE11 and Neoplasms
 Nervous System Diseases Antibodies  >45 publications with MRE11 and Nervous System Diseases
 Breast Neoplasms Antibodies  >29 publications with MRE11 and Breast Neoplasms
 ATAXIA-TELANGIECTASIA-LIKE DISORDER Antibodies  >29 publications with MRE11 and ATAXIA-TELANGIECTASIA-LIKE DISORDER
 Colorectal Neoplasms Antibodies  >21 publications with MRE11 and Colorectal Neoplasms
 Congenital Abnormalities Antibodies  >13 publications with MRE11 and Congenital Abnormalities
 Neoplasms, Experimental Antibodies  >11 publications with MRE11 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >10 publications with MRE11 and Ovarian Neoplasms
 Anemia Antibodies  >10 publications with MRE11 and Anemia
 Cell Transformation, Neoplastic Antibodies  >9 publications with MRE11 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with MRE11 and Blood
 Lung Antibodies  >17 publications with MRE11 and Lung
 Brain Antibodies  >11 publications with MRE11 and Brain
 Kidney Antibodies  >9 publications with MRE11 and Kidney
 Prostate Antibodies  >6 publications with MRE11 and Prostate
 Muscle Antibodies  >5 publications with MRE11 and Muscle
 Testis Antibodies  >5 publications with MRE11 and Testis
 Skin Antibodies  >5 publications with MRE11 and Skin
 Liver Antibodies  >5 publications with MRE11 and Liver
 Bladder Antibodies  >5 publications with MRE11 and Bladder
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