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anti-MTNR1A antibody :: Rabbit MTNR1A Antibody

Scan QR to view Datasheet Catalog #    MBS855199
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MTNR1A, Antibody

 Also Known As   

MTNR1A Antibody

 Product Synonym Names    Melatonin receptor type 1A; Mel-1A-R; Mel1a melatonin receptor; MTNR1A
 Product Gene Name   

anti-MTNR1A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600665
 3D Structure    ModBase 3D Structure for P48039
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    MTR1A antibody detects endogenous levels of total MTR1A protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 86%, Positives = 93%); Rat (Identities = 86%, Positives = 93%)
 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human MTR1A.
 Pathway    GPCR
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-MTNR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MTNR1A antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-MTNR1A antibody   

Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-MTNR1A antibody    IF: 1:100~1:500, ELISA: 1:5000
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 Testing Data of anti-MTNR1A antibody    Peptide - +
Immunofluorescence analysis of HepG2 cells, using MTR1A antibody.
anti-MTNR1A antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for MTNR1A. It may not necessarily be applicable to this product.
 NCBI GI #    5174593
 NCBI GeneID    4543
 NCBI Accession #    NP_005949.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005958.3 [Other Products]
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 UniProt Primary Accession #    P48039 [Other Products]
 UniProt Secondary Accession #    A0AVC5; B0M0L2 [Other Products]
 UniProt Related Accession #    P48039 [Other Products]
 Molecular Weight    39,375 Da
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 NCBI Official Full Name    melatonin receptor type 1A
 NCBI Official Synonym Full Names    melatonin receptor 1A
 NCBI Official Symbol    MTNR1A [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    melatonin receptor type 1A; mel1a receptor
 UniProt Protein Name    Melatonin receptor type 1A
 Protein Family    Melatonin receptor
 UniProt Gene Name    MTNR1A [Similar Products]
 UniProt Synonym Gene Names    Mel-1A-R; Mel1a receptor [Similar Products]
 UniProt Entry Name    MTR1A_HUMAN
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 NCBI Summary for MTNR1A    This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MTNR1A    MTNR1A: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; hormone binding; melatonin receptor activity

Biological Process: circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of cGMP biosynthetic process; mating behavior
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Product References and Citations for anti-MTNR1A antibody

   Reppert S.M., Neuron 13:1177-1185(1994).
Ebisawa T., Biochem. Biophys. Res. Commun. 262:832-837(1999).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
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 Research Articles on MTNR1A    1. Suggest that physiological regulation of the melatonin receptors may result from complex and subtle mechanisms, a small difference in affinity between the active and inactive states of the receptor, and spontaneous coupling to G-proteins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MTNR1A antibodyPathways associated with anti-MTNR1A antibody
 Reference Product  PubMed Publications
 MTNR1B antibody  >27 publications with MTNR1A and MTNR1B
 NMU antibody  >1 publications with MTNR1A and NMU
 Products by Pathway  Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with anti-MTNR1A antibodyOrgans/Tissues associated with anti-MTNR1A antibody
 Disease Name  Pubmed Publications
 Child Development Disorders, Pervasive Antibodies  >2 publications with MTNR1A and Child Development Disorders, Pervasive
 Movement Disorders Antibodies  >1 publications with MTNR1A and Movement Disorders
 Brain Diseases Antibodies  >1 publications with MTNR1A and Brain Diseases
 Kidney Diseases Antibodies  >1 publications with MTNR1A and Kidney Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with MTNR1A and Drug-Related Side Effects and Adverse Reactions
 Necrosis Antibodies  >1 publications with MTNR1A and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with MTNR1A and Liver
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