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anti-MYBPC1 antibody :: Rabbit MYBPC1 Antibody

Scan QR to view Datasheet Catalog #    MBS856317
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MYBPC1, Antibody

 Also Known As   

MYBPC1 Antibody

 Product Synonym Names    Myosin-binding protein C slow-type; Slow MyBP-C; C-protein skeletal muscle slow isoform
 Product Gene Name   

anti-MYBPC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614915
 3D Structure    ModBase 3D Structure for Q00872
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    MYBPC1 antibody detects endogenous levels of total MYBPC1 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 91%, Positives = 91%); Rat (Identities = 91%, Positives = 91%)
 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human MYBPC1.
 Pathway    Intermediates
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-MYBPC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MYBPC1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-MYBPC1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-MYBPC1 antibody    WB: 1:500~1:1000, ELISA: 1:20000
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 Testing Data of anti-MYBPC1 antibody    Western blot analysis of extracts from 293 cells, using MYBPC1 antibody.
For Research Use Only
anti-MYBPC1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for MYBPC1. It may not necessarily be applicable to this product.
 NCBI GI #    360039217
 NCBI GeneID    4604
 NCBI Accession #    NP_001241647.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001254718.1 [Other Products]
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 UniProt Primary Accession #    Q00872 [Other Products]
 UniProt Secondary Accession #    Q15497; Q17RR7; Q569K7; B4DKR5; B7Z8G8; B7ZL02; B7ZL09; B7ZL10; E7ESM5; E7EWS6; G3XAE8 [Other Products]
 UniProt Related Accession #    Q00872 [Other Products]
 Molecular Weight    129,074 Da
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 NCBI Official Full Name    myosin-binding protein C, slow-type isoform 5
 NCBI Official Synonym Full Names    myosin binding protein C, slow type
 NCBI Official Symbol    MYBPC1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    myosin-binding protein C, slow-type; slow MyBP-C; skeletal muscle C-protein; C-protein, skeletal muscle slow isoform
 UniProt Protein Name    Myosin-binding protein C, slow-type
 UniProt Synonym Protein Names   
C-protein, skeletal muscle slow isoform
 Protein Family    Myosin-binding protein
 UniProt Gene Name    MYBPC1 [Similar Products]
 UniProt Synonym Gene Names    MYBPCS; Slow MyBP-C [Similar Products]
 UniProt Entry Name    MYPC1_HUMAN
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 NCBI Summary for MYBPC1    This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for MYBPC1    MYBPC1: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B). A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected. Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis. Belongs to the immunoglobulin superfamily. MyBP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Myosin-binding

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: myofibril; cytosol

Molecular Function: protein binding; structural constituent of muscle; titin binding; actin binding

Biological Process: cell adhesion; muscle filament sliding

Disease: Lethal Congenital Contracture Syndrome 4; Arthrogryposis, Distal, Type 1b
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Product References and Citations for anti-MYBPC1 antibody

   Fuerst D.O., J. Cell Sci. 102:769-778(1992).
Weber F.E., Eur. J. Biochem. 216:661-669(1993).
Bechtel S., BMC Genomics 8:399-399(2007).
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 Research Articles on MYBPC1    1. Mutations in the MYH7 gene, rather than in the MYBPC3 gene, were also related to a worse prognosis. This is the first work characterizing HC molecular epidemiology in the Brazilian population for the 3 most important genes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYBPC1 antibodyPathways associated with anti-MYBPC1 antibody
 Reference Product  PubMed Publications
 TNNI2 antibody  >2 publications with MYBPC1 and TNNI2
 TNNT3 antibody  >2 publications with MYBPC1 and TNNT3
 MYL2 antibody  >2 publications with MYBPC1 and MYL2
 MYH3 antibody  >2 publications with MYBPC1 and MYH3
 NEB antibody  >1 publications with MYBPC1 and NEB
 Products by Pathway  Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
Diseases associated with anti-MYBPC1 antibodyOrgans/Tissues associated with anti-MYBPC1 antibody
 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >6 publications with MYBPC1 and Muscular Diseases
 Nervous System Diseases Antibodies  >2 publications with MYBPC1 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with MYBPC1 and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with MYBPC1 and Adenocarcinoma
 Craniofacial Abnormalities Antibodies  >1 publications with MYBPC1 and Craniofacial Abnormalities
 Edema Antibodies  >1 publications with MYBPC1 and Edema
 Disease Models, Animal Antibodies  >1 publications with MYBPC1 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with MYBPC1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >13 publications with MYBPC1 and Muscle
 Embryonic Tissue Antibodies  >2 publications with MYBPC1 and Embryonic Tissue
 Heart Antibodies  >2 publications with MYBPC1 and Heart
 Brain Antibodies  >1 publications with MYBPC1 and Brain
 Liver Antibodies  >1 publications with MYBPC1 and Liver
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