NP_000423.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,789 Da
NCBI Official Full Name
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
NCBI Official Synonym Full Names
myosin light chain 2
NCBI Protein Information
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
UniProt Protein Name
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
UniProt Synonym Protein Names
Cardiac myosin light chain 2
UniProt Synonym Gene Names
NCBI Summary for MYL2
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for MYL2
Contractile protein that plays a role in heart development and function (). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly ().
Research Articles on MYL2
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Disclaimer
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Products associated with anti-MYL2 antibody
Pathways associated with anti-MYL2 antibody
Diseases associated with anti-MYL2 antibody
Disease Name |
Pubmed Publications |
Cardiovascular Diseases Antibodies |
>35 publications with MYL2 and Cardiovascular Diseases |
Heart Diseases Antibodies |
>33 publications with MYL2 and Heart Diseases |
Cardiomyopathy, Hypertrophic Antibodies |
>27 publications with MYL2 and Cardiomyopathy, Hypertrophic |
Cardiomyopathy, Hypertrophic, Familial Antibodies |
>11 publications with MYL2 and Cardiomyopathy, Hypertrophic, Familial |
Hypertrophy Antibodies |
>10 publications with MYL2 and Hypertrophy |
Hypertension Antibodies |
>5 publications with MYL2 and Hypertension |
Cardiomegaly Antibodies |
>5 publications with MYL2 and Cardiomegaly |
Neoplasms Antibodies |
>5 publications with MYL2 and Neoplasms |
Cardiomyopathy, Familial Hypertrophic, 10 Antibodies |
>4 publications with MYL2 and Cardiomyopathy, Familial Hypertrophic, 10 |
Inflammation Antibodies |
>2 publications with MYL2 and Inflammation |
Organs/Tissues associated with anti-MYL2 antibody
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