NP_000259.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,515 Da
NCBI Official Full Name
merlin isoform 1
NCBI Official Synonym Full Names
neurofibromin 2
NCBI Protein Information
merlin
UniProt Protein Name
Merlin
UniProt Synonym Protein Names
Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin
UniProt Synonym Gene Names
NCBI Summary for MERL
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]
UniProt Comments for MERL
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Product References and Citations for anti-MERL antibody
Guang-Hui Xiao, et, al. (2005) Mol. Cell. Biol; 25: 2384-2394. Hi-Su Yang, et, al. (2006) Cancer Res; 66: 2708-2715. R Bohni, et, al. (1994) J. Biol. Chem; 269: 14541-14545. Adam J. Ratner, et, al. (2001) J. Biol. Chem; 276: 19267-19275.
Research Articles on MERL
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Products associated with anti-MERL antibody
Pathways associated with anti-MERL antibody
Diseases associated with anti-MERL antibody
Organs/Tissues associated with anti-MERL antibody
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