NP_000354.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
troponin I, cardiac muscle
NCBI Official Synonym Full Names
troponin I3, cardiac type
NCBI Official Synonym Symbols
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF [Similar Products]
NCBI Protein Information
troponin I, cardiac muscle
UniProt Protein Name
Troponin I, cardiac muscle
UniProt Synonym Protein Names
Cardiac troponin I
UniProt Synonym Gene Names
NCBI Summary for CTNI
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
UniProt Comments for CTNI
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Research Articles on CTNI
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Products associated with anti-CTNI antibody
Pathways associated with anti-CTNI antibody
Diseases associated with anti-CTNI antibody
Disease Name |
Pubmed Publications |
Cardiovascular Diseases Antibodies |
>66 publications with CTNI and Cardiovascular Diseases |
Heart Diseases Antibodies |
>65 publications with CTNI and Heart Diseases |
Cardiomyopathies Antibodies |
>56 publications with CTNI and Cardiomyopathies |
Cardiomyopathy, Hypertrophic, Familial Antibodies |
>25 publications with CTNI and Cardiomyopathy, Hypertrophic, Familial |
Cardiomyopathy, Dilated Antibodies |
>18 publications with CTNI and Cardiomyopathy, Dilated |
CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7 Antibodies |
>9 publications with CTNI and CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7 |
Cardiomyopathy, Restrictive Antibodies |
>6 publications with CTNI and Cardiomyopathy, Restrictive |
Nervous System Diseases Antibodies |
>4 publications with CTNI and Nervous System Diseases |
Ventricular Dysfunction, Left Antibodies |
>3 publications with CTNI and Ventricular Dysfunction, Left |
Hypertension Antibodies |
>3 publications with CTNI and Hypertension |
Organs/Tissues associated with anti-CTNI antibody
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