Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow EIF2AK2 rightarrow Monclonal EIF2AK2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Procollagen Type IIA N-Prop (PIIANP) ELISA Kit
 • Regulatory-associated protein of mTOR (RPTOR) ELISA Kit
 • Adiponectin (ADIPOQ) Protein
 • chemokine (C-C motif) receptor 6 (CCR6) ELISA Kit
 • NTM Antibody
 • FTO Antibody
 • Nuclear Membrane Marker Antibody
 • 40S ribosomal protein S10 (RPS10) ELISA Kit
 • Agamous-like MADS-box protein AGL6 (AGL6) Recombinant Protein
 • Heparin cofactor II-thrombin (HCII-T) ELISA Kit
 • PPP2R5D Antibody
 • CAD Antibody
 • Phospholipase A2, membrane associated (Pla2g2a) ELISA Kit
 • Pro-Nerve Growth Factor 1 (pro-NGF1) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-EIF2AK2 antibody :: Mouse anti-Human EIF2AK2 Monclonal Antibody

Scan QR to view Datasheet Catalog #    MBS477369
Unit / Price
0.1 mL  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EIF2AK2, Monclonal Antibody

 Also Known As   

Anti-EIF2AK2 Mouse mAb

 Product Synonym Names    Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; Protein kinase RNA-activated; PKR; Protein kinase R; Tyrosine-protein kinase EIF2AK2; p68 kinase; EIF2AK2; PKR; PRKR
 Product Gene Name   

anti-EIF2AK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    176871
 3D Structure    ModBase 3D Structure for P19525
Section Bar
 Clonality    Monclonal
 Clone Number    1441CT628.33.40
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Purity/Purification    Affinity Purified
Section Bar
 Immunogen    This EIF2AK2 antibody is generated from mice immunized with a recombinant protein.
Section Bar
 Other Notes    Small volumes of anti-EIF2AK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-EIF2AK2 antibody   

Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-EIF2AK2 antibody    WB: 1:500
ICC: 1:25
Section Bar
 Immunofluorescence (IF) of anti-EIF2AK2 antibody    Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0. 1% Triton X-100 permeabilized HeLa (human cervical epithelial adenocarcinoma cell line) cells labeling Pdx1 with MBS477369 at 1/25 dilution, followed by Dylight? 488-conjugated goat anti-mouse Ig
anti-EIF2AK2 antibody Immunofluorescence (IF) image
Section Bar
 Western Blot (WB) of anti-EIF2AK2 antibody    Western blot analysis of lysates from A431, HepG2, SH-SY5Y cell line (from left to right), using EIF2AK2 Antibody . MBS477369 was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 20u03bcg per lane.
anti-EIF2AK2 antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for EIF2AK2. It may not necessarily be applicable to this product.
 NCBI GI #    208431827
 NCBI GeneID    5610
 NCBI Accession #    NP_001129123.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135651.2 [Other Products]
Section Bar
 UniProt Primary Accession #    P19525 [Other Products]
 UniProt Secondary Accession #    Q52M43; Q7Z6F6; Q9UIR4; A8K3P0; D6W584; E9PC80 [Other Products]
 UniProt Related Accession #    P19525 [Other Products]
 Molecular Weight    57,391 Da
Table BarTOPTable Bar
 NCBI Official Full Name    interferon-induced, double-stranded RNA-activated protein kinase isoform a
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 2 alpha kinase 2
 NCBI Official Symbol    EIF2AK2 [Similar Products]
 NCBI Official Synonym Symbols   
PKR; PRKR; EIF2AK1; PPP1R83
[Similar Products]
 NCBI Protein Information    interferon-induced, double-stranded RNA-activated protein kinase
 UniProt Protein Name    Interferon-induced, double-stranded RNA-activated protein kinase
 UniProt Synonym Protein Names   
Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; Protein kinase RNA-activated; PKR; Protein kinase R
 Protein Family    Interferon-induced, double-stranded RNA-activated protein kinase
 UniProt Gene Name    EIF2AK2 [Similar Products]
 UniProt Synonym Gene Names    PKR; PRKR; eIF-2A protein kinase 2; PKR; Protein kinase R [Similar Products]
Section Bar
 NCBI Summary for EIF2AK2    The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Section Bar
 UniProt Comments for EIF2AK2    IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin.
Table BarTOPTable Bar
 Research Articles on EIF2AK2    1. Here, the authors report that LRP16 selectively interacts and activates double-stranded RNA-dependent kinase (PKR), and also acts as scaffolds to assist the formation of a ternary complex of PKR and IKKbeta, prolonging the polymers of ADP-ribose (PAR)-dependent nuclear factor kappa B (NF-kappaB) transactivation caused by DNA-damaging agents and confers acquired chemoresistance.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-EIF2AK2 antibodyPathways associated with anti-EIF2AK2 antibody
 Reference Product  PubMed Publications
 STAT1 antibody  >3 publications with EIF2AK2 and STAT1
 STAT3 antibody  >2 publications with EIF2AK2 and STAT3
 CASP8 antibody  >1 publications with EIF2AK2 and CASP8
 CASP3 antibody  >1 publications with EIF2AK2 and CASP3
 EIF2S1 antibody  >1 publications with EIF2AK2 and EIF2S1
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with anti-EIF2AK2 antibodyOrgans/Tissues associated with anti-EIF2AK2 antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >4 publications with EIF2AK2 and Brain Diseases
 Nervous System Diseases Antibodies  >4 publications with EIF2AK2 and Nervous System Diseases
 Inflammation Antibodies  >4 publications with EIF2AK2 and Inflammation
 Neurodegenerative Diseases Antibodies  >3 publications with EIF2AK2 and Neurodegenerative Diseases
 Lung Diseases Antibodies  >2 publications with EIF2AK2 and Lung Diseases
 Liver Diseases Antibodies  >2 publications with EIF2AK2 and Liver Diseases
 Melanoma Antibodies  >1 publications with EIF2AK2 and Melanoma
 Neoplasms Antibodies  >1 publications with EIF2AK2 and Neoplasms
 Necrosis Antibodies  >1 publications with EIF2AK2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with EIF2AK2 and Blood
 Lung Antibodies  >2 publications with EIF2AK2 and Lung
 Skin Antibodies  >2 publications with EIF2AK2 and Skin
 Bone Antibodies  >1 publications with EIF2AK2 and Bone
 Lymph Node Antibodies  >1 publications with EIF2AK2 and Lymph Node
 Liver Antibodies  >1 publications with EIF2AK2 and Liver
 Brain Antibodies  >1 publications with EIF2AK2 and Brain
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions