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anti-YWHAB antibody :: Mouse anti-Mammal 14-3-3 Binding Motif Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS603373 anti-YWHAB antibody
Unit / Price
0.1 mL  /  $590 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

14-3-3 Binding Motif (YWHAB), Monoclonal Antibody

 Also Known As   

14-3-3 Binding Motif, phosphorylated (Ser)

 Product Synonym Names    Anti -14-3-3 Binding Motif, phosphorylated (Ser)
 Product Gene Name   

anti-YWHAB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (43514240..43537173). Location: 20q13.1
 OMIM    601289
 3D Structure    ModBase 3D Structure for P31946
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3i2
 Host    Mouse
 Species Reactivity    Mammal
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 Specificity    Recognizes peptides/proteins containing phospho-Ser surrounded by Pro at the +2 position and Arg/Lys at the -3 position. By ELISA, recognizes a wide range of peptides containing this phosphorylated 14-3-3 binding motif in a manner that is phospho-specific and largely independent of the surrounding amino acid sequence. Weakly crossreacts with sequences containing phospho-Thr instead of phospho-Ser in this motif and with sequences containing phospho-Ser surrounded by Phe at the +1 position and Arg/Lys at the -3 position. No crossreactivity is observed with corresponding nonphosphorylated sequences.
 Purity/Purification    Ascites
Ascites
 Form/Format    Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 0.02% sodium azide, 50% glycerol.
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 Immunogen    Synthetic phospho-(Ser) 14-3-3 binding motif peptides (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-YWHAB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-YWHAB antibody

   The 14-3-3 proteins are a highly conserved family of proteins involved in the regulation of cell survival, apoptosis, proliferation and checkpoint control (1-5). Biological regulation by 14-3-3 is mediated through phosphorylation-dependent protein-protein interactions (6). Two different phospho-Ser-containing motifs are found within nearly all known 14-3-3 binding proteins (7). Motif 1 (Arg/Lys and Ser at positions -3 and -2, phospho-Ser at position 0, and Pro at position +2) is found in critical regulatory proteins including Bad, cdc25c, FKHRL1, PKC and c-Raf (5,7).
 Product Categories/Family for anti-YWHAB antibody    Antibodies; Abs to 14-3-3
 Applications Tested/Suitable for anti-YWHAB antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-YWHAB antibody    Suitable for use in ELISA, Western Blot and Immunoprecipitation.
Dilution: Peptide ELISA: 1:1000
Western Blot: 1:4000
Immunoprecipitation: 1:20 (Denatured proteins).
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NCBI/Uniprot data below describe general gene information for YWHAB. It may not necessarily be applicable to this product.
 NCBI GI #    21328448
 NCBI GeneID    7529
 NCBI Accession #    NP_647539.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_139323.3 [Other Products]
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 UniProt Primary Accession #    P31946 [Other Products]
 UniProt Secondary Accession #    A8K9K2; E1P616 [Other Products]
 UniProt Related Accession #    P31946 [Other Products]
 Molecular Weight    28,082 Da [Similar Products]
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 NCBI Official Full Name    14-3-3 protein beta/alpha
 NCBI Official Synonym Full Names    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
 NCBI Official Symbol    YWHAB [Similar Products]
 NCBI Official Synonym Symbols   
HS1; GW128; YWHAA; KCIP-1
[Similar Products]
 NCBI Protein Information    14-3-3 protein beta/alpha; 14-3-3 alpha; protein 1054; brain protein 14-3-3, beta isoform; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
 UniProt Protein Name    14-3-3 protein beta/alpha
 UniProt Synonym Protein Names   
Protein 1054; Protein kinase C inhibitor protein 1
 Protein Family    14-3-3 protein
 UniProt Gene Name    YWHAB [Similar Products]
 UniProt Synonym Gene Names    KCIP-1 [Similar Products]
 UniProt Entry Name    1433B_HUMAN
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 NCBI Summary for YWHAB    This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for YWHAB    14-3-3 beta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: focal adhesion; cytoplasmic vesicle membrane; membrane; transcriptional repressor complex; perinuclear region of cytoplasm; cytoplasm; melanosome; cytosol; nucleus

Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; enzyme binding; histone deacetylase binding; protein complex binding; phosphoprotein binding; transcription corepressor activity; phosphoserine binding

Biological Process: positive regulation of catalytic activity; negative regulation of protein amino acid dephosphorylation; epidermal growth factor receptor signaling pathway; axon guidance; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; protein heterooligomerization; apoptosis; MAPKKK cascade; small GTPase mediated signal transduction; Ras protein signal transduction; cytoplasmic sequestering of protein; insulin receptor signaling pathway; innate immune response; gene expression; negative regulation of transcription, DNA-dependent; vascular endothelial growth factor receptor signaling pathway; protein targeting
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 Research Articles on YWHAB    1. These results indicate that the six YWHAB polymorphisms are not associated with the genetic susceptibility to sporadic Creutzfeldt-Jakob disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-YWHAB antibodyPathways associated with anti-YWHAB antibody
 Reference Product  PubMed Publications
 CDC25B antibody  >3 publications with YWHAB and CDC25B
 BAD antibody  >2 publications with YWHAB and BAD
 CDC25C antibody  >2 publications with YWHAB and CDC25C
 HDAC4 antibody  >1 publications with YWHAB and HDAC4
 TSC2 antibody  >1 publications with YWHAB and TSC2
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-YWHAB antibodyOrgans/Tissues associated with anti-YWHAB antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >15 publications with YWHAB and Neoplasms
 Nervous System Diseases Antibodies  >12 publications with YWHAB and Nervous System Diseases
 Carcinoma Antibodies  >6 publications with YWHAB and Carcinoma
 Liver Diseases Antibodies  >4 publications with YWHAB and Liver Diseases
 Inflammation Antibodies  >3 publications with YWHAB and Inflammation
 Intestinal Neoplasms Antibodies  >3 publications with YWHAB and Intestinal Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with YWHAB and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >2 publications with YWHAB and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with YWHAB and Neoplasm Metastasis
 Seizures Antibodies  >2 publications with YWHAB and Seizures
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with YWHAB and Brain
 Blood Antibodies  >5 publications with YWHAB and Blood
 Liver Antibodies  >4 publications with YWHAB and Liver
 Muscle Antibodies  >4 publications with YWHAB and Muscle
 Kidney Antibodies  >3 publications with YWHAB and Kidney
 Nerve Antibodies  >3 publications with YWHAB and Nerve
 Lung Antibodies  >2 publications with YWHAB and Lung
 Ganglia Antibodies  >2 publications with YWHAB and Ganglia
 Vascular Antibodies  >2 publications with YWHAB and Vascular
 Heart Antibodies  >2 publications with YWHAB and Heart
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