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anti-Protein kinase C inhibitor protein; Protein 1054 antibody :: Mouse 14-3-3 beta /zeta Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS565120
Western Blot (WB)
Unit / Price
0.025 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

14-3-3 beta /zeta (Protein kinase C inhibitor protein; Protein 1054), Monoclonal Antibody

 Also Known As   

14-3-3 beta /zeta monoclonal antibody (22-ii-D8B)

 Product Gene Name   

anti-Protein kinase C inhibitor protein; Protein 1054 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601289
 3D Structure    ModBase 3D Structure for P31946
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    22-ii-D8B
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat, Bovine, Dog, Monkey, Porcine, Rabbit, Sheep
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 Specificity    Recognizes human, mouse, rat, bovine, dog, monkey, pig, rabbit and sheep 14-3-3 beta/zeta.
 Purity/Purification    Protein G affinity purified.
 Form/Format    Liquid. In PBS, pH 7.2, containing 0.1mM PMSF, 50% glycerol, and 0.09% sodium azide.
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 Immunogen    Lysed transformed human amnion cells (AMA).
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 Preparation and Storage    Long term storage: -20 degree C
 Other Notes    Small volumes of anti-Protein kinase C inhibitor protein; Protein 1054 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Protein kinase C inhibitor protein; Protein 1054 antibody

   14-3-3 proteins are highly conserved proteins that play a role in both signal transduction and progression through the cell cycle by binding to and regulating a number of different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms.
 Product Categories/Family for anti-Protein kinase C inhibitor protein; Protein 1054 antibody    DNA Regulation & Transcription; Cell Signaling
 Applications Tested/Suitable for anti-Protein kinase C inhibitor protein; Protein 1054 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-Protein kinase C inhibitor protein; Protein 1054 antibody    Western Blot (1ug/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
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 Western Blot (WB) of anti-Protein kinase C inhibitor protein; Protein 1054 antibody    anti-Protein kinase C inhibitor protein; Protein 1054 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Protein kinase C inhibitor protein; Protein 1054. It may not necessarily be applicable to this product.
 NCBI GI #    4507949
 NCBI GeneID    7529
 NCBI Accession #    NP_003395 [Other Products]
 NCBI GenBank Nucleotide #    NM_003404.4 [Other Products]
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 UniProt Primary Accession #    P31946 [Other Products]
 UniProt Secondary Accession #    A8K9K2; E1P616 [Other Products]
 UniProt Related Accession #    P31946 [Other Products]
 Molecular Weight    27,850 Da
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 NCBI Official Full Name    14-3-3 protein beta/alpha
 NCBI Official Synonym Full Names    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
 NCBI Official Symbol    YWHAB [Similar Products]
 NCBI Official Synonym Symbols   
HS1; GW128; YWHAA; KCIP-1; HEL-S-1
[Similar Products]
 NCBI Protein Information    14-3-3 protein beta/alpha
 UniProt Protein Name    14-3-3 protein beta/alpha
 UniProt Synonym Protein Names   
Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
 UniProt Gene Name    YWHAB [Similar Products]
 UniProt Synonym Gene Names    KCIP-1 [Similar Products]
 UniProt Entry Name    1433B_HUMAN
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 NCBI Summary for Protein kinase C inhibitor protein; Protein 1054    This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Protein kinase C inhibitor protein; Protein 1054    14-3-3 beta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; focal adhesion; melanosome; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; transcriptional repressor complex

Molecular Function: enzyme binding; histone deacetylase binding; phosphoprotein binding; phosphoserine binding; protein binding; protein C-terminus binding; protein complex binding; protein domain specific binding; transcription corepressor activity

Biological Process: activation of MAPKK activity; apoptosis; axon guidance; cytoplasmic sequestering of protein; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; gene expression; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of protein amino acid dephosphorylation; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of catalytic activity; programmed cell death; protein heterooligomerization; protein targeting; Ras protein signal transduction; regulation of mRNA stability; small GTPase mediated signal transduction; transcription initiation from RNA polymerase II promoter; vascular endothelial growth factor receptor signaling pathway; viral reproduction
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 Research Articles on Protein kinase C inhibitor protein; Protein 1054    1. These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Protein kinase C inhibitor protein; Protein 1054 antibodyPathways associated with anti-Protein kinase C inhibitor protein; Protein 1054 antibody
 Reference Product  PubMed Publications
 CDC25B antibody  >3 publications with Protein kinase C inhibitor protein; Protein 1054 and CDC25B
 CDC25C antibody  >2 publications with Protein kinase C inhibitor protein; Protein 1054 and CDC25C
 MAP2K1 antibody  >1 publications with Protein kinase C inhibitor protein; Protein 1054 and MAP2K1
 FOXO3 antibody  >1 publications with Protein kinase C inhibitor protein; Protein 1054 and FOXO3
 HDAC4 antibody  >1 publications with Protein kinase C inhibitor protein; Protein 1054 and HDAC4
 TSC2 antibody  >1 publications with Protein kinase C inhibitor protein; Protein 1054 and TSC2
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Butyrate Response Factor 1 (BRF1) Binds And Destabilizes MRNA Pathway antibodies  Butyrate Response Factor 1 (BRF1) Binds And Destabilizes MRNA Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-Protein kinase C inhibitor protein; Protein 1054 antibodyOrgans/Tissues associated with anti-Protein kinase C inhibitor protein; Protein 1054 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >16 publications with Protein kinase C inhibitor protein; Protein 1054 and Nervous System Diseases
 Carcinoma Antibodies  >7 publications with Protein kinase C inhibitor protein; Protein 1054 and Carcinoma
 Liver Diseases Antibodies  >4 publications with Protein kinase C inhibitor protein; Protein 1054 and Liver Diseases
 Inflammation Antibodies  >4 publications with Protein kinase C inhibitor protein; Protein 1054 and Inflammation
 Cardiovascular Diseases Antibodies  >3 publications with Protein kinase C inhibitor protein; Protein 1054 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with Protein kinase C inhibitor protein; Protein 1054 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with Protein kinase C inhibitor protein; Protein 1054 and Liver Neoplasms
 Neurodegenerative Diseases Antibodies  >2 publications with Protein kinase C inhibitor protein; Protein 1054 and Neurodegenerative Diseases
 Seizures Antibodies  >2 publications with Protein kinase C inhibitor protein; Protein 1054 and Seizures
 Neoplasm Metastasis Antibodies  >2 publications with Protein kinase C inhibitor protein; Protein 1054 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with Protein kinase C inhibitor protein; Protein 1054 and Brain
 Blood Antibodies  >8 publications with Protein kinase C inhibitor protein; Protein 1054 and Blood
 Liver Antibodies  >6 publications with Protein kinase C inhibitor protein; Protein 1054 and Liver
 Vascular Antibodies  >5 publications with Protein kinase C inhibitor protein; Protein 1054 and Vascular
 Muscle Antibodies  >5 publications with Protein kinase C inhibitor protein; Protein 1054 and Muscle
 Kidney Antibodies  >3 publications with Protein kinase C inhibitor protein; Protein 1054 and Kidney
 Nerve Antibodies  >3 publications with Protein kinase C inhibitor protein; Protein 1054 and Nerve
 Prostate Antibodies  >2 publications with Protein kinase C inhibitor protein; Protein 1054 and Prostate
 Lung Antibodies  >2 publications with Protein kinase C inhibitor protein; Protein 1054 and Lung
 Ganglia Antibodies  >2 publications with Protein kinase C inhibitor protein; Protein 1054 and Ganglia
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