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anti-14.3.3 beta antibody :: Mouse 14.3.3 beta Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS533204
Western Blot
Unit / Price
0.1 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

14.3.3 beta, Monoclonal Antibody

 Also Known As   

14.3.3 beta antibody

 Product Synonym Names    Monoclonal 14.3.3 beta; Anti-14-3-3 beta; Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein; KCIP-1; HS 1; beta polypeptide 14 3 3 protein beta/alpha; 14-3-3 beta; Protein kinase C inhibitor protein 1; 14/3/3 beta; 14.3.3 beta; HS1; Tyrosine 3 Monooxygenase/Tryptophan 5 Monooxygenase Activation Protein beta Polypeptide; Protein 1054; beta polypeptide; GW128; KCIP 1; YWHAB; Brain protein 14 3 3 beta isoform; GW 128; KCIP1
 Product Gene Name   

anti-14.3.3 beta antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601289
 3D Structure    ModBase 3D Structure for P31946
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 Clonality    Monoclonal
 Isotype    IgG2a kappa
 Clone Number    J2E9
 Host    Mouse
 Species Reactivity    To be determined by end-user.
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 Specificity    Human
 Purity/Purification    14-3-3 beta antibody was purified by protein-G affinity chromatography
 Form/Format    Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
 Concentration    1 mg/ml (lot specific)
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 Source Note    Anti-human 14-3-3 beta antibody, clone J2E9, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human YWHAB protein.
 Biological Significance    The 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms,beta, gamma,epsilon, sigma, zeta, tau and theta that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 beta has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery.
 Immunogen    14-3-3 beta antibody was raised in mouse using recombinant human 14-3-3 beta (1-246aa) purified from E Coli as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-14.3.3 beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-14.3.3 beta antibody

   Mouse monoclonal 14-3-3 beta antibody
 Product Categories/Family for anti-14.3.3 beta antibody    Signal Transduction
 Applications Tested/Suitable for anti-14.3.3 beta antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-14.3.3 beta antibody    WB: 1:1,000-1:2,000
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 Western Blot of anti-14.3.3 beta antibody    Western Blot analysis of 14.3.3 beta antibody
Cell lysates of HeLa(30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human 14-3-3 beta (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conj ugated to HRP and an ECL detection system.
anti-14.3.3 beta antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for 14.3.3 beta. It may not necessarily be applicable to this product.
 NCBI GI #    21328448
 NCBI GeneID    7529
 NCBI Accession #    NP_647539.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_139323.2 [Other Products]
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 UniProt Primary Accession #    P31946 [Other Products]
 UniProt Secondary Accession #    A8K9K2; E1P616 [Other Products]
 UniProt Related Accession #    P31946 [Other Products]
 Molecular Weight    27,850 Da
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 NCBI Official Full Name    14-3-3 protein beta/alpha
 NCBI Official Synonym Full Names    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
 NCBI Official Symbol    YWHAB [Similar Products]
 NCBI Official Synonym Symbols   
HS1; GW128; YWHAA; KCIP-1; HEL-S-1
[Similar Products]
 NCBI Protein Information    14-3-3 protein beta/alpha
 UniProt Protein Name    14-3-3 protein beta/alpha
 UniProt Synonym Protein Names   
Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
 UniProt Gene Name    YWHAB [Similar Products]
 UniProt Synonym Gene Names    KCIP-1 [Similar Products]
 UniProt Entry Name    1433B_HUMAN
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 NCBI Summary for 14.3.3 beta    This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for 14.3.3 beta    14-3-3 beta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: cytoplasmic vesicle membrane; focal adhesion; transcriptional repressor complex; membrane; perinuclear region of cytoplasm; cytoplasm; melanosome; nucleus; cytosol

Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; enzyme binding; histone deacetylase binding; protein complex binding; phosphoprotein binding; transcription corepressor activity; phosphoserine binding

Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of protein amino acid dephosphorylation; positive regulation of catalytic activity; axon guidance; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; protein heterooligomerization; apoptosis; MAPKKK cascade; small GTPase mediated signal transduction; Ras protein signal transduction; cytoplasmic sequestering of protein; insulin receptor signaling pathway; innate immune response; gene expression; negative regulation of transcription, DNA-dependent; vascular endothelial growth factor receptor signaling pathway; protein targeting
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 Research Articles on 14.3.3 beta    1. miR-152 controls both the expression of 14-3-3beta and HLA-G and exerts a dual role in tumor cells by both altering the immunogenicity and the tumorigenicity
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-14.3.3 beta antibodyPathways associated with anti-14.3.3 beta antibody
 Reference Product  PubMed Publications
 CDC25B antibody  >3 publications with 14.3.3 beta and CDC25B
 CDC25C antibody  >2 publications with 14.3.3 beta and CDC25C
 FOXO3 antibody  >1 publications with 14.3.3 beta and FOXO3
 HDAC4 antibody  >1 publications with 14.3.3 beta and HDAC4
 TSC2 antibody  >1 publications with 14.3.3 beta and TSC2
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway antibodies  Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-14.3.3 beta antibodyOrgans/Tissues associated with anti-14.3.3 beta antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >6 publications with 14.3.3 beta and Carcinoma
 Liver Diseases Antibodies  >4 publications with 14.3.3 beta and Liver Diseases
 Inflammation Antibodies  >4 publications with 14.3.3 beta and Inflammation
 Adenocarcinoma Antibodies  >3 publications with 14.3.3 beta and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >2 publications with 14.3.3 beta and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >2 publications with 14.3.3 beta and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with 14.3.3 beta and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with 14.3.3 beta and Liver Neoplasms
 Seizures Antibodies  >2 publications with 14.3.3 beta and Seizures
 Neurodegenerative Diseases Antibodies  >2 publications with 14.3.3 beta and Neurodegenerative Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with 14.3.3 beta and Brain
 Liver Antibodies  >6 publications with 14.3.3 beta and Liver
 Blood Antibodies  >6 publications with 14.3.3 beta and Blood
 Muscle Antibodies  >5 publications with 14.3.3 beta and Muscle
 Vascular Antibodies  >4 publications with 14.3.3 beta and Vascular
 Kidney Antibodies  >3 publications with 14.3.3 beta and Kidney
 Nerve Antibodies  >3 publications with 14.3.3 beta and Nerve
 Lung Antibodies  >2 publications with 14.3.3 beta and Lung
 Ganglia Antibodies  >2 publications with 14.3.3 beta and Ganglia
 Adipose Tissue Antibodies  >2 publications with 14.3.3 beta and Adipose Tissue
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