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anti-YWHAG antibody :: Mouse anti-Human 14-3-3, gamma Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6003904 anti-YWHAG antibody
Unit / Price
0.05 mg  /  $610 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

14-3-3, gamma (YWHAG), Monoclonal Antibody

 Also Known As   

14-3-3, gamma, ID (Protein Kinase C Inhibitor Protein 1, KCIP-1, 14-3-3 Protein gamma, N-terminally Processed, YWHAG)

 Product Synonym Names    Anti -14-3-3, gamma, ID (Protein Kinase C Inhibitor Protein 1, KCIP-1, 14-3-3 Protein gamma, N-terminally Processed, YWHAG)
 Product Gene Name   

anti-YWHAG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (75956108..75988342, complement). Location: 7q11.23
 OMIM    605356
 3D Structure    ModBase 3D Structure for P61981
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 Clonality    Monoclonal
 Isotype    IgG2b,k
 Clone Number    J3H10
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human YWHAG.
 Purity/Purification    Purified
Purified
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
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 Immunogen    Recombinant corresponding to human 14-3-3 gamma aa1-247, expressed in E. coli.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-YWHAG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-YWHAG antibody

   The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. The initially described alpha and delta isoforms are confirmed to be phosphorylated forms of beta and zeta respectively. Through their amino-terminal alpha helical region, 14-3-3 proteins forms homo- or heterodimers that interact with a wide variety of proteins: transcription factors, metabolic enzymes, cytoskeletal proteins, kinases, phosphatases and other signaling molecules. The interaction of 14-3-3 proteins with their targets is primarily through a phospho-Ser/Thr motif. However, binding to divergent phospho-Ser/Thr motifs, as well as phosphorylation independent interactions has been observed. 14-3-3 binding masks specific sequences of the target protein, and therefore, modulates target protein localization, phosphorylation state, stability and molecular interactions. 14-3-3 proteins may also induce target protein conformational changes which modify target protein function. Distinct temporal and spatial expression patterns of 14-3-3 isoforms have been observed in develop- ment and in acute response to extracellular signals and drugs, suggesting that 14-3-3 isoforms may perform differ- ent functions despite their sequence similarities. Several studies suggest that 14-3-3 isoforms are differentially regulated in cancer and neurological syndromes.
 Product Categories/Family for anti-YWHAG antibody    Antibodies; Abs to 14-3-3
 Applications Tested/Suitable for anti-YWHAG antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-YWHAG antibody    Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:1000-1:2000
Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml
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NCBI/Uniprot data below describe general gene information for YWHAG. It may not necessarily be applicable to this product.
 NCBI GI #    21464101
 NCBI GeneID    7532
 NCBI Accession #    NP_036611.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012479.3 [Other Products]
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 UniProt Primary Accession #    P61981 [Other Products]
 UniProt Secondary Accession #    O70457; P35214; Q6FH52; Q9UDP2; Q9UN99 [Other Products]
 UniProt Related Accession #    P61981 [Other Products]
 Molecular Weight    28,303 Da [Similar Products]
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 NCBI Official Full Name    14-3-3 protein gamma
 NCBI Official Synonym Full Names    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
 NCBI Official Symbol    YWHAG [Similar Products]
 NCBI Official Synonym Symbols   
14-3-3GAMMA
[Similar Products]
 NCBI Protein Information    14-3-3 protein gamma; KCIP-1; 14-3-3 gamma; protein kinase C inhibitor protein 1
 UniProt Protein Name    14-3-3 protein gamma
 UniProt Synonym Protein Names   
Protein kinase C inhibitor protein 1
 Protein Family    14-3-3 protein
 UniProt Gene Name    YWHAG [Similar Products]
 UniProt Synonym Gene Names    KCIP-1 [Similar Products]
 UniProt Entry Name    1433G_HUMAN
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 NCBI Summary for YWHAG    This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
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 UniProt Comments for YWHAG    14-3-3 gamma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Homodimer. Interacts with SAMSN1. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT. Highly expressed in brain, skeletal muscle, and heart. Belongs to the 14-3-3 family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: cytoplasmic vesicle membrane; focal adhesion; membrane; cytosol

Molecular Function: insulin-like growth factor receptor binding; protein kinase C inhibitor activity; protein domain specific binding; protein binding; protein kinase C binding; receptor tyrosine kinase binding

Biological Process: cellular response to insulin stimulus; regulation of neuron differentiation; apoptosis; organelle organization and biogenesis; negative regulation of protein kinase activity; regulation of signal transduction; regulation of synaptic plasticity; mitotic cell cycle; G2/M transition of mitotic cell cycle; protein targeting
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 Research Articles on YWHAG    1. Increased expression of 14-3-3gamma in breast cancer is associated significantly with tumor progression and poor prognosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to 14-3-3, gamma, ID (Protein Kinase C Inhibitor Protein 1, KCIP-1, 14-3-3 Prote
 Catalog #  Product Name  Catalog #  Product Name
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Pathways associated with anti-YWHAG antibodyDiseases associated with anti-YWHAG antibody
 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with YWHAG and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with YWHAG and Brain Diseases
 Cardiovascular Diseases Antibodies  >2 publications with YWHAG and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with YWHAG and Heart Diseases
 Disease Models, Animal Antibodies  >1 publications with YWHAG and Disease Models, Animal
 Learning Disorders Antibodies  >1 publications with YWHAG and Learning Disorders
 Hypertrophy Antibodies  >1 publications with YWHAG and Hypertrophy
 Necrosis Antibodies  >1 publications with YWHAG and Necrosis
Organs/Tissues associated with anti-YWHAG antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with YWHAG and Brain
 Heart Antibodies  >3 publications with YWHAG and Heart
 Muscle Antibodies  >3 publications with YWHAG and Muscle
 Nerve Antibodies  >3 publications with YWHAG and Nerve
 Bone Antibodies  >2 publications with YWHAG and Bone
 Bone Marrow Antibodies  >2 publications with YWHAG and Bone Marrow
 Blood Antibodies  >1 publications with YWHAG and Blood
 Lung Antibodies  >1 publications with YWHAG and Lung
 Kidney Antibodies  >1 publications with YWHAG and Kidney
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