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anti-YWHAG antibody :: Mouse anti-Human 14-3-3, gamma Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS631763 anti-YWHAG antibody
Unit / Price
0.1 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

14-3-3, gamma (YWHAG), Monoclonal Antibody

 Also Known As   

14-3-3, gamma (Protein kinase C inhibitor protein 1, KCIP-1, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, YWHAG)

 Product Synonym Names    Anti -14-3-3, gamma (Protein kinase C inhibitor protein 1, KCIP-1, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, YWHAG)
 Product Gene Name   

anti-YWHAG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (75956108..75988342, complement). Location: 7q11.23
 OMIM    605356
 3D Structure    ModBase 3D Structure for P61981
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    9A71
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human 14-3-3 gamma. Reacts with the naturally occurring human form of 14-3-3 gamma, where the N-terminal Met is removed, resulting in an acetylated N-terminal Val. Unprocessed (non-modified) 14-3-3 gamma is not recognized by this antibody.
 Purity/Purification    Ascites
Mouse ascites
 Form/Format    Supplied as a liquid. May contain azide. See Certificate of Analysis.
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 Immunogen    N-terminal fragment of human 14-3-3 gamma where the N-terminal Val was acetylated
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-YWHAG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-YWHAG antibody

   14-3-3 proteins are present as multigene families in most organisms. Signal-induced phosphorylation has the ability to change protein function. Sometimes, however, phosphorylation is not enough to change a protein's function. 14-3-3 proteins play an important role of bringing signal transduction to completion. They regulate many cellular processes that are important in cancer biology, such as apoptosis and cell-cycle checkpoints.
 Product Categories/Family for anti-YWHAG antibody    Antibodies; Abs to 14-3-3
 Applications Tested/Suitable for anti-YWHAG antibody   

Western Blot (WB)

 Application Notes for anti-YWHAG antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 1:3,000. Detects a band of ~ 33kD.
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NCBI/Uniprot data below describe general gene information for YWHAG. It may not necessarily be applicable to this product.
 NCBI GI #    21464101
 NCBI GeneID    7532
 NCBI Accession #    NP_036611.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012479.3 [Other Products]
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 UniProt Primary Accession #    P61981 [Other Products]
 UniProt Secondary Accession #    O70457; P35214; Q6FH52; Q9UDP2; Q9UN99 [Other Products]
 UniProt Related Accession #    P61981 [Other Products]
 Molecular Weight    28,303 Da [Similar Products]
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 NCBI Official Full Name    14-3-3 protein gamma
 NCBI Official Synonym Full Names    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
 NCBI Official Symbol    YWHAG [Similar Products]
 NCBI Official Synonym Symbols   
14-3-3GAMMA
[Similar Products]
 NCBI Protein Information    14-3-3 protein gamma; KCIP-1; 14-3-3 gamma; OTTHUMP00000161136; protein kinase C inhibitor protein 1
 UniProt Protein Name    14-3-3 protein gamma
 UniProt Synonym Protein Names   
Protein kinase C inhibitor protein 1
 Protein Family    14-3-3 protein
 UniProt Gene Name    YWHAG [Similar Products]
 UniProt Entry Name    1433G_HUMAN
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 NCBI Summary for YWHAG    This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq]
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 UniProt Comments for YWHAG    14-3-3 gamma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Homodimer. Interacts with SAMSN1. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT. Highly expressed in brain, skeletal muscle, and heart. Belongs to the 14-3-3 family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: cytoplasmic vesicle membrane; focal adhesion; membrane; cytosol

Molecular Function: insulin-like growth factor receptor binding; protein kinase C inhibitor activity; protein domain specific binding; protein binding; protein kinase C binding; receptor tyrosine kinase binding

Biological Process: cellular response to insulin stimulus; regulation of neuron differentiation; apoptosis; organelle organization and biogenesis; regulation of synaptic plasticity; regulation of signal transduction; negative regulation of protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; protein targeting
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 Research Articles on YWHAG    1. a new role for 14-3-3gamma in protecting p21 from MDMX-mediated proteasomal turnover, which may partially account for DNA damage-induced elevation of p21 levels independent of p53.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-YWHAG antibodyPathways associated with anti-YWHAG antibody
 Reference Product  PubMed Publications
 SPTBN1 antibody  >1 publications with YWHAG and SPTBN1
 SON antibody  >1 publications with YWHAG and SON
 CCT2 antibody  >1 publications with YWHAG and CCT2
 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 FoxO Family Signaling Pathway antibodies  FoxO Family Signaling Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
Diseases associated with anti-YWHAG antibodyOrgans/Tissues associated with anti-YWHAG antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with YWHAG and Nervous System Diseases
 Neurologic Manifestations Antibodies  >3 publications with YWHAG and Neurologic Manifestations
 Congenital Abnormalities Antibodies  >2 publications with YWHAG and Congenital Abnormalities
 Cardiomegaly Antibodies  >1 publications with YWHAG and Cardiomegaly
 Learning Disorders Antibodies  >1 publications with YWHAG and Learning Disorders
 Ataxia Antibodies  >1 publications with YWHAG and Ataxia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with YWHAG and Brain
 Heart Antibodies  >3 publications with YWHAG and Heart
 Muscle Antibodies  >3 publications with YWHAG and Muscle
 Bone Antibodies  >2 publications with YWHAG and Bone
 Bone Marrow Antibodies  >2 publications with YWHAG and Bone Marrow
 Blood Antibodies  >1 publications with YWHAG and Blood
 Nerve Antibodies  >1 publications with YWHAG and Nerve
 Lung Antibodies  >1 publications with YWHAG and Lung
 Kidney Antibodies  >1 publications with YWHAG and Kidney
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