NP_006817.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
14-3-3 protein theta
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
NCBI Protein Information
14-3-3 protein theta; 14-3-3 protein tau; 14-3-3 protein T-cell
UniProt Protein Name
14-3-3 protein theta
UniProt Synonym Protein Names
14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1
UniProt Entry Name
1433T_HUMAN
NCBI Summary for 14-3-3 theta/tau
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
UniProt Comments for 14-3-3 theta/tau
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. Ref.12
Subunit structure: Homodimer. Interacts with CDK16
By similarity. Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the 'Ser-241' phosphorylated form of PDPK1. Ref.11 Ref.12 Ref.13 Ref.15 Ref.23
Subcellular location: Cytoplasm. Note: In neurons, axonally transported to the nerve terminals.
Tissue specificity: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. Ref.10
Post-translational modification: Ser-232 is probably phosphorylated by CK1. Ref.9
Sequence similarities: Belongs to the 14-3-3 family.
Research Articles on 14-3-3 theta/tau
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Pathways associated with anti-14-3-3 theta/tau antibody
Organs/Tissues associated with anti-14-3-3 theta/tau antibody
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