View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-14-3-3 antibody :: Rabbit 14-3-3 Monoclonal Antibody Catalog # MBS179851 Unit / Price 0.1 mL / $460 +1 FREE 8GB USB 5x0.1 mL / $1,880 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name 14-3-3, Monoclonal Antibody Full Product Name Anti-14-3-3 Rabbit Monoclonal Antibody Product Synonym Names 14-3-3 protein beta/alpha; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1; 14-3-3 protein beta/alpha, N-terminally processed; YWHAB Product Gene Name anti-14-3-3 antibody[Similar Products] Product Synonym Gene Name YWHAB[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM X57346 mRNA 3D Structure ModBase 3D Structure for P31946 Clonality Monoclonal Host Rabbit Species Reactivity Human, Mouse, Rat Purity/Purification Affinity-chromatography Form/Format Liquid Immunogen A synthesized peptide derived from human 41701 Subcellular Localization Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Contents Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Preparation and Storage Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. ISO Certification Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory. Other Notes Small volumes of anti-14-3-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-14-3-3 antibody Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activatation of MAP kinases via AKAP13. Product Categories/Family for anti-14-3-3 antibody Neuroscience; Neurology Process; Neural Signal Transduction; Signal Transduction; Adapters; Cytoplasmic; Neuroscience; Cell Type Marker; neuron marker; synapse marker; Stem Cells; Signaling Pathways; wnt; 14-3-3 Applications Tested/Suitable for anti-14-3-3 antibody Western Blot (WB) Application Notes for anti-14-3-3 antibody WB: 1:5000-1:20000 Western Blot (WB) of anti-14-3-3 antibody Western blot analysis of 14-3-3 expression in (1) HeLa cell lysate; (2) 3T3 cell lysate; (3) PC-12 cell lysate (MBS179851).Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-YWHAB monoclonal antibody overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for YWHAB TOP NCBI/Uniprot data below describe general gene information for 14-3-3. It may not necessarily be applicable to this product. NCBI GI # 4507949 NCBI GeneID 7529 NCBI Accession # NP_003395.1 [Other Products] NCBI GenBank Nucleotide # NM_003404.4 [Other Products] UniProt Primary Accession # P31946 [Other Products] UniProt Secondary Accession # A8K9K2; E1P616[Other Products] Molecular Weight 28082 MW TOP NCBI Official Full Name 14-3-3 protein beta/alpha UniProt Protein Name 14-3-3 protein beta/alpha UniProt Synonym Protein Names Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1 Protein Family 14-3-3 protein UniProt Gene Name YWHAB [Similar Products] UniProt Synonym Gene Names KCIP-1 [Similar Products] TOP TOP UniProt Comments for 14-3-3 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-14-3-3 antibody Reference Product PubMed Publications CDC25B antibody >3 publications with 14-3-3 and CDC25B CDC25A antibody >3 publications with 14-3-3 and CDC25A IGF1R antibody >3 publications with 14-3-3 and IGF1R CDC25C antibody >2 publications with 14-3-3 and CDC25C YWHAE antibody >2 publications with 14-3-3 and YWHAE SRC antibody >2 publications with 14-3-3 and SRC KCNK3 antibody >1 publications with 14-3-3 and KCNK3 EPB41L1 antibody >1 publications with 14-3-3 and EPB41L1 BAD antibody >1 publications with 14-3-3 and BAD TSC2 antibody >1 publications with 14-3-3 and TSC2 Pathways associated with anti-14-3-3 antibody Products by Pathway Pathway Diagram ARMS-mediated Activation Pathway antibodies ARMS-mediated Activation Pathway Diagram Activation Of BAD And Translocation To Mitochondria Pathway antibodies Activation Of BAD And Translocation To Mitochondria Pathway Diagram Activation Of BH3-only Proteins Pathway antibodies Activation Of BH3-only Proteins Pathway Diagram Adaptive Immune System Pathway antibodies Adaptive Immune System Pathway Diagram Alpha6-Beta4 Integrin Signaling Pathway antibodies Alpha6-Beta4 Integrin Signaling Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Axon Guidance Pathway antibodies Axon Guidance Pathway Diagram Calcium Regulation In The Cardiac Cell Pathway antibodies Calcium Regulation In The Cardiac Cell Pathway Diagram Cell Cycle Pathway antibodies Cell Cycle Pathway Diagram Cell Cycle Pathway antibodies Cell Cycle Pathway Diagram Diseases associated with anti-14-3-3 antibody Disease Name Pubmed Publications Neoplasms Antibodies >15 publications with 14-3-3 and Neoplasms Nervous System Diseases Antibodies >11 publications with 14-3-3 and Nervous System Diseases Carcinoma Antibodies >6 publications with 14-3-3 and Carcinoma Liver Diseases Antibodies >3 publications with 14-3-3 and Liver Diseases Intestinal Neoplasms Antibodies >3 publications with 14-3-3 and Intestinal Neoplasms Cardiovascular Diseases Antibodies >2 publications with 14-3-3 and Cardiovascular Diseases Inflammation Antibodies >2 publications with 14-3-3 and Inflammation Liver Neoplasms Antibodies >2 publications with 14-3-3 and Liver Neoplasms Neoplasm Metastasis Antibodies >2 publications with 14-3-3 and Neoplasm Metastasis Seizures Antibodies >2 publications with 14-3-3 and Seizures Organs/Tissues associated with anti-14-3-3 antibody Organ/Tissue Name Pubmed Publications Brain Antibodies >11 publications with 14-3-3 and Brain Blood Antibodies >4 publications with 14-3-3 and Blood Muscle Antibodies >4 publications with 14-3-3 and Muscle Kidney Antibodies >3 publications with 14-3-3 and Kidney Liver Antibodies >3 publications with 14-3-3 and Liver Nerve Antibodies >3 publications with 14-3-3 and Nerve Lung Antibodies >2 publications with 14-3-3 and Lung Ganglia Antibodies >2 publications with 14-3-3 and Ganglia Vascular Antibodies >2 publications with 14-3-3 and Vascular Heart Antibodies >2 publications with 14-3-3 and Heart TOP © 2006-24 MyBioSource.com. 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