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anti-4-1BBL antibody :: Rat anti-Mouse 4-1BBL Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690970 anti-4-1BBL antibody
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

4-1BBL, Monoclonal Antibody

 Also Known As   

Rat Anti-Mouse 4-1BBL

 Product Synonym Names    Anti-mouse 4-1BB Ligand (#3H19)
 Product Gene Name   

anti-4-1BBL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000083.6 (57105264..57107757). Location: 17 D; 17
 3D Structure    ModBase 3D Structure for P41274
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    (MAB0875)
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    This antibody detects mouse 4-1BB ligand in Western blots.
 Purity/Purification    > 98% by SDS-PAGE and HPLC analyses
 Form/Format    The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS). Lyophilized samples are stable for 2 years from date of receipt when stored at
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 Endotoxin Level    < 0.1 ng per g of 4-1BBL
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-4-1BBL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-4-1BBL antibody

   4-1BB ligand (4-1BBL) is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF9. Mouse 4-1BBL cDNA encodes a 309 amino acid residues (aa) protein with an 82 aa Nterminal cytoplasmic domain, a 21 aa transmembrane domain and a 206 aa C terminal extracellular domain. The extracellular domain of 4-1BBL has a tertiary structure similar to that of other TNFSF members, but shares only low aa sequence homology (14-16%). Murine 4-1BBL shares 36% aa sequence identity with its human counterpart. 4-1BBL is predominantly expressed on activated antigen presenting cells (APCs) such as B cells, macrophages and dendritic cells (DCs). It is also expressed on most T and B lymphoma cell lines. A soluble 4-1BBL is released from the cell surface following cellular activation via proteolytic cleavage by one or more sheddases. By analogy to other TNFSF ligands, both the soluble and transmembrane 4-1BBL are expected to exist as noncovalent homotrimers. 4-1BBL binds 4-1BB, a TNF receptor superfamily member, TNFRSF9, which is also known as CD137 and ILA (induced by lymphocyte activation). 41BB is expressed on activated CD4+ and CD8+ T cells, thymocytes, and NK cells. It is also expressed on monocytes, neutrophils, DCs and eosinophils. In response to 4-1BBL binding, 4-1BB transduces a T cell costimulatory signal in both CD4+ and CD8+ T cells to promote survival and enhance proliferation, cytokine production and effector function. In dendritic cells, 4-1BB is a DC-activating molecule that enhances cytokine production and upregulates expression of B71 and B72 costimulatory molecules.
 Applications Tested/Suitable for anti-4-1BBL antibody   

Flow Cytometry (FC/FACS), Blocking

 Application Notes for anti-4-1BBL antibody    Western Blot: Yes (1:50-200)
FACS: Yes (1:500-1000)
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NCBI/Uniprot data below describe general gene information for 4-1BBL. It may not necessarily be applicable to this product.
 NCBI GI #    6678389
 NCBI GeneID    21950
 NCBI Accession #    NP_033430.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_009404.3 [Other Products]
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 UniProt Primary Accession #    P41274 [Other Products]
 UniProt Related Accession #    P41274 [Other Products]
 Molecular Weight    19.5 kDa
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 9
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 9
 NCBI Official Symbol    Tnfsf9 [Similar Products]
 NCBI Official Synonym Symbols   
Ly63l; 4-1BBL; Cd137l; 4-1BB-L; AI848817
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 9; 4-1BB ligand
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 9
 UniProt Synonym Protein Names   
4-1BB ligand
 UniProt Gene Name    Tnfsf9 [Similar Products]
 UniProt Synonym Gene Names    Cd137l; Cd157l; Ly63l; 4-1BBL [Similar Products]
 UniProt Entry Name    TNFL9_MOUSE
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 UniProt Comments for 4-1BBL    Function: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

Subunit structure: Homotrimer

Potential.

Subcellular location: Membrane; Single-pass type II membrane protein.

Sequence similarities: Belongs to the tumor necrosis factor family.
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 Research Articles on 4-1BBL    1. CD137-CD137L interactions increase myelopoiesis during infection
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-4-1BBL antibodyDiseases associated with anti-4-1BBL antibody
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >125 publications with 4-1BBL and Necrosis
 Neoplasms Antibodies  >57 publications with 4-1BBL and Neoplasms
 Immune System Diseases Antibodies  >28 publications with 4-1BBL and Immune System Diseases
 Inflammation Antibodies  >16 publications with 4-1BBL and Inflammation
 Neoplasms, Experimental Antibodies  >13 publications with 4-1BBL and Neoplasms, Experimental
 Liver Diseases Antibodies  >11 publications with 4-1BBL and Liver Diseases
 Liver Neoplasms Antibodies  >10 publications with 4-1BBL and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >8 publications with 4-1BBL and Cardiovascular Diseases
 Liver Neoplasms, Experimental Antibodies  >6 publications with 4-1BBL and Liver Neoplasms, Experimental
 Lung Neoplasms Antibodies  >5 publications with 4-1BBL and Lung Neoplasms
Organs/Tissues associated with anti-4-1BBL antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >14 publications with 4-1BBL and Liver
 Lymph Node Antibodies  >8 publications with 4-1BBL and Lymph Node
 Lung Antibodies  >7 publications with 4-1BBL and Lung
 Skin Antibodies  >7 publications with 4-1BBL and Skin
 Brain Antibodies  >4 publications with 4-1BBL and Brain
 Stomach Antibodies  >3 publications with 4-1BBL and Stomach
 Connective Tissue Antibodies  >1 publications with 4-1BBL and Connective Tissue
 Embryonic Tissue Antibodies  >1 publications with 4-1BBL and Embryonic Tissue
 Thymus Antibodies  >1 publications with 4-1BBL and Thymus
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