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anti-EIF4EBP1 antibody :: Rabbit 4E Binding Protein 1, non-phosphorylated Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS633422 anti-EIF4EBP1 antibody
Unit / Price
0.1 mL  /  $590 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

4E Binding Protein 1, non-phosphorylated (EIF4EBP1), Monoclonal Antibody

 Also Known As   

4E Binding Protein 1, non-phosphorylated (Thr46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP)

 Product Synonym Names    Anti -4E Binding Protein 1, non-phosphorylated (Thr46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP)
 Product Gene Name   

anti-EIF4EBP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 8; NC_000008.10 (37888020..37917883). Location: 8p12
 OMIM    602223
 3D Structure    ModBase 3D Structure for Q13541
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    7H1
 Host    Rabbit
 Species Reactivity    Human, Monkey, Mouse, Rat
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 Specificity    Detects endogenous levels of 4E-BP1 only when dephosphorylated at Thr46. Crossreacts with 4E-BP2 and 4E-BP3 dephosphorylated at equivalent sites.
 Purity/Purification    Supernatant
Supernatant
 Form/Format    Supplied as a liquid in 10mM sodium HEPES (pH 7.5), 150mM NaCl, 100ug/ml BSA, 50% glycerol and less than 0.02% sodium azide.
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 Immunogen    Synthetic peptide (KLH-coupled) corresponding to residues surrounding Thr46 of human 4E-BP1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-EIF4EBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EIF4EBP1 antibody

   4E-BP1 (also known as PHAS-1) when bound to eIF4E, inhibits cap-dependent translation. Upon hyperphosphorylation of 4E-BP1 this interaction is disrupted and cap-dependent translation is activated (1). Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity (2,3). Multiple 4E-BP1 residues are phosphorylated in vivo (4); while phosphorylation by FRAP/mTOR on Thr37 and Thr46 does not prevent the binding of 4E-BP-1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70 (5).
 Product Categories/Family for anti-EIF4EBP1 antibody    Antibodies; Abs to Translation Initiation Factors
 Applications Tested/Suitable for anti-EIF4EBP1 antibody   

ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)

 Application Notes for anti-EIF4EBP1 antibody    Suitable for use in Flow Cytometry, ELISA, Western Blot.
Dilution: Western blot 1:1000
Flow Cytometry 1:200
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NCBI/Uniprot data below describe general gene information for EIF4EBP1. It may not necessarily be applicable to this product.
 NCBI GI #    561630
 NCBI GeneID    1978
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 UniProt Primary Accession #    Q13541 [Other Products]
 UniProt Secondary Accession #    Q6IBN3; B2R502; D3DSW8 [Other Products]
 UniProt Related Accession #    Q13541 [Other Products]
 Molecular Weight    12,580 Da [Similar Products]
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 NCBI Official Full Name    4E-binding protein 1
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 4E binding protein 1
 NCBI Official Symbol    EIF4EBP1 [Similar Products]
 NCBI Official Synonym Symbols   
BP-1; 4EBP1; 4E-BP1; PHAS-I; MGC4316
[Similar Products]
 NCBI Protein Information    eukaryotic translation initiation factor 4E-binding protein 1; OTTHUMP00000225572; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1
 UniProt Protein Name    Eukaryotic translation initiation factor 4E-binding protein 1
 UniProt Synonym Protein Names   
Phosphorylated heat- and acid-stable protein regulated by insulin 1
 Protein Family    Eukaryotic translation initiation factor 4E-binding protein
 UniProt Gene Name    EIF4EBP1 [Similar Products]
 UniProt Entry Name    4EBP1_HUMAN
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 NCBI Summary for EIF4EBP1    This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq]
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 UniProt Comments for EIF4EBP1    4E-BP1: binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: nucleoplasm; protein complex; cytoplasm; cytosol

Molecular Function: protein binding; translation repressor activity; eukaryotic initiation factor 4E binding

Biological Process: negative regulation of translational initiation; response to ethanol; TOR signaling pathway; cellular protein metabolic process; translation; translational initiation; insulin receptor signaling pathway; gene expression; positive regulation of mitotic cell cycle; negative regulation of protein complex assembly; lung development; G1/S transition of mitotic cell cycle
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 Research Articles on EIF4EBP1    1. potential prognostic factor for survival in patients with lung adenocarcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EIF4EBP1 antibodyPathways associated with anti-EIF4EBP1 antibody
 Reference Product  PubMed Publications
 EIF4E antibody  >407 publications with EIF4EBP1 and EIF4E
 MTOR antibody  >360 publications with EIF4EBP1 and MTOR
 AKT1 antibody  >40 publications with EIF4EBP1 and AKT1
 MAPK1 antibody  >22 publications with EIF4EBP1 and MAPK1
 ATM antibody  >11 publications with EIF4EBP1 and ATM
 RPS6KB1 antibody  >2 publications with EIF4EBP1 and RPS6KB1
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
Diseases associated with anti-EIF4EBP1 antibodyOrgans/Tissues associated with anti-EIF4EBP1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >179 publications with EIF4EBP1 and Neoplasms
 Carcinoma Antibodies  >43 publications with EIF4EBP1 and Carcinoma
 Tuberous Sclerosis Antibodies  >38 publications with EIF4EBP1 and Tuberous Sclerosis
 Hypertrophy Antibodies  >34 publications with EIF4EBP1 and Hypertrophy
 Immune System Diseases Antibodies  >29 publications with EIF4EBP1 and Immune System Diseases
 Breast Neoplasms Antibodies  >27 publications with EIF4EBP1 and Breast Neoplasms
 Leukemia Antibodies  >25 publications with EIF4EBP1 and Leukemia
 Insulin Resistance Antibodies  >23 publications with EIF4EBP1 and Insulin Resistance
 Male Urogenital Diseases Antibodies  >21 publications with EIF4EBP1 and Male Urogenital Diseases
 Urogenital Neoplasms Antibodies  >20 publications with EIF4EBP1 and Urogenital Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >147 publications with EIF4EBP1 and Muscle
 Blood Antibodies  >91 publications with EIF4EBP1 and Blood
 Vascular Antibodies  >36 publications with EIF4EBP1 and Vascular
 Heart Antibodies  >35 publications with EIF4EBP1 and Heart
 Liver Antibodies  >33 publications with EIF4EBP1 and Liver
 Brain Antibodies  >31 publications with EIF4EBP1 and Brain
 Kidney Antibodies  >28 publications with EIF4EBP1 and Kidney
 Lung Antibodies  >27 publications with EIF4EBP1 and Lung
 Pancreas Antibodies  >19 publications with EIF4EBP1 and Pancreas
 Prostate Antibodies  >13 publications with EIF4EBP1 and Prostate
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