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anti-TNFAIP3 antibody :: Mouse anti-Human A-20/TNFAIP3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS668220
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A-20/TNFAIP3, Monoclonal Antibody

★Popular Item★
 Also Known As   

A-20/TNFAIP3,Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20)

 Product Synonym Names    TNFAIP3, OTUD7C
 Product Gene Name   

anti-TNFAIP3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    191163
 3D Structure    ModBase 3D Structure for P21580
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 Clonality    Monoclonal
 Isotype    IgG1, Kappa
 Clone Number    ABM1G20
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Protein G choromatography
 Form/Format    Purified
25 ug in 50 uL/ 100 ug in 200 uL PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
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 Immunogen    A partial length recombinant protein from C terminal portion of A20 was used as the immunogen for this antibody.
 Buffer    PBS containing 0.05%BSA and 0.05% sodium azide.
 Target Modification    No
 Produced from Ascites    No
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 Preparation and Storage    Store the antibody at 4C, stable for 6 months. For long-term storage, store at -20C. Avoid repeated freeze and thaw cycles.
 Other Notes    Small volumes of anti-TNFAIP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TNFAIP3 antibody

   Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20)
 Applications Tested/Suitable for anti-TNFAIP3 antibody   

FACS, WB

 Application Notes for anti-TNFAIP3 antibody    Western Blot: 4-6 ug/mL
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 Western Blot (WB) of anti-TNFAIP3 antibody    Expression analysis of A20. Anti-A20 antibody (Clone: ABM1G20) was tested at 4 ug/ml on THP-1 Lysate.
anti-TNFAIP3 antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC) of anti-TNFAIP3 antibody    Cell surface FLOW analysis of A20 (Clone : ABM1G20) on HepG2 cells using 0.5 ug/10^6 cells of antibody. Goat anti-mouse PE conjugate was used as secondary antibody. Green represents isotope control , red represents anti-A20 antibody
anti-TNFAIP3 antibody Flow Cytometry (FC) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for TNFAIP3. It may not necessarily be applicable to this product.
 NCBI GI #    395393995
 NCBI GeneID    7128
 NCBI Accession #    NP_001257436.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001270507.1 [Other Products]
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 UniProt Primary Accession #    P21580 [Other Products]
 UniProt Secondary Accession #    Q2HIX9; Q5VXQ7; Q9NSR6; B2R767; E1P588 [Other Products]
 UniProt Related Accession #    P21580 [Other Products]
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 NCBI Official Full Name    tumor necrosis factor alpha-induced protein 3
 NCBI Official Synonym Full Names    TNF alpha induced protein 3
 NCBI Official Symbol    TNFAIP3 [Similar Products]
 NCBI Official Synonym Symbols   
A20; AISBL; OTUD7C; TNFA1P2
[Similar Products]
 NCBI Protein Information    tumor necrosis factor alpha-induced protein 3
 UniProt Protein Name    Tumor necrosis factor alpha-induced protein 3
 UniProt Synonym Protein Names   
OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20
 Protein Family    Tumor necrosis factor alpha-induced protein
 UniProt Gene Name    TNFAIP3 [Similar Products]
 UniProt Synonym Gene Names    OTUD7C; TNF alpha-induced protein 3 [Similar Products]
 UniProt Entry Name    TNAP3_HUMAN
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 NCBI Summary for TNFAIP3    This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
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 UniProt Comments for TNFAIP3    TNFAIP3: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF. Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6; the interaction is inhibited by HTLV-1 protein Tax. By TNF. Belongs to the peptidase C64 family.

Protein type: Apoptosis; Protease; EC 3.4.19.12; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: cytoplasm; cytosol; lysosome; nucleus

Molecular Function: DNA binding; kinase binding; ligase activity; protease binding; protein binding; protein self-association; ubiquitin binding; ubiquitin-protein ligase activity; ubiquitin-specific protease activity; zinc ion binding

Biological Process: apoptosis; B-1 B cell homeostasis; inflammatory response; inhibition of NF-kappaB transcription factor; negative regulation of B cell activation; negative regulation of bone resorption; negative regulation of chronic inflammatory response; negative regulation of cyclin-dependent protein kinase activity; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; negative regulation of innate immune response; negative regulation of interferon type I production; negative regulation of interleukin-1 beta production; negative regulation of interleukin-2 production; negative regulation of interleukin-6 production; negative regulation of protein ubiquitination; negative regulation of smooth muscle cell proliferation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 3 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of toll-like receptor 5 signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of protein catabolic process; protein deubiquitination; protein oligomerization; regulation of defense response to virus by host; regulation of germinal center formation; regulation of inflammatory response; response to molecule of bacterial origin; response to muramyl dipeptide
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 Research Articles on TNFAIP3    1. a miR-125a/A20-initiated and caspase-8-targeted mechanism by which HBx modulates apoptotic signaling, is reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFAIP3 antibodyPathways associated with anti-TNFAIP3 antibody
 Reference Product  PubMed Publications
 TNIP1 antibody  >60 publications with TNFAIP3 and TNIP1
 TRAF6 antibody  >45 publications with TNFAIP3 and TRAF6
 IKBKB antibody  >37 publications with TNFAIP3 and IKBKB
 TRAF2 antibody  >23 publications with TNFAIP3 and TRAF2
 TAX1BP1 antibody  >17 publications with TNFAIP3 and TAX1BP1
 RIPK1 antibody  >12 publications with TNFAIP3 and RIPK1
 TNIP2 antibody  >11 publications with TNFAIP3 and TNIP2
 IKBKG antibody  >6 publications with TNFAIP3 and IKBKG
 TBK1 antibody  >6 publications with TNFAIP3 and TBK1
 Products by Pathway  Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
Diseases associated with anti-TNFAIP3 antibodyOrgans/Tissues associated with anti-TNFAIP3 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >278 publications with TNFAIP3 and Necrosis
 Inflammation Antibodies  >218 publications with TNFAIP3 and Inflammation
 Arthritis, Rheumatoid Antibodies  >95 publications with TNFAIP3 and Arthritis, Rheumatoid
 Lupus Erythematosus, Systemic Antibodies  >63 publications with TNFAIP3 and Lupus Erythematosus, Systemic
 Cardiovascular Diseases Antibodies  >53 publications with TNFAIP3 and Cardiovascular Diseases
 Psoriasis Antibodies  >43 publications with TNFAIP3 and Psoriasis
 Nervous System Diseases Antibodies  >32 publications with TNFAIP3 and Nervous System Diseases
 Disease Models, Animal Antibodies  >31 publications with TNFAIP3 and Disease Models, Animal
 Lung Diseases Antibodies  >22 publications with TNFAIP3 and Lung Diseases
 Heart Diseases Antibodies  >19 publications with TNFAIP3 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >138 publications with TNFAIP3 and Blood
 Vascular Antibodies  >60 publications with TNFAIP3 and Vascular
 Skin Antibodies  >32 publications with TNFAIP3 and Skin
 Lung Antibodies  >32 publications with TNFAIP3 and Lung
 Liver Antibodies  >31 publications with TNFAIP3 and Liver
 Muscle Antibodies  >31 publications with TNFAIP3 and Muscle
 Heart Antibodies  >28 publications with TNFAIP3 and Heart
 Intestine Antibodies  >24 publications with TNFAIP3 and Intestine
 Brain Antibodies  >19 publications with TNFAIP3 and Brain
 Kidney Antibodies  >19 publications with TNFAIP3 and Kidney
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