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anti-ADAM17 antibody :: Mouse A Disintegrin And Metalloprotease 17 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2025765 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $90 +1 FREE 8GB USB
0.02 mg  /  $100 +1 FREE 8GB USB
0.05 mg  /  $130 +1 FREE 8GB USB
0.1 mg  /  $160 +1 FREE 8GB USB
0.2 mg  /  $200 +1 FREE 8GB USB
1 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloprotease 17 (ADAM17), Monoclonal Antibody

★Popular Item★
 Also Known As   

Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17)

 Product Gene Name   

anti-ADAM17 antibody

[Similar Products]
 Matching Pairs    Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
Antigen: A Disintegrin And Metalloprotease 17 (ADAM17) (MBS2011531)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
APC-CY7 Conjugated Antibody: A Disintegrin And Metalloprotease 17 (ADAM17) (MBS2056485)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
PE Conjugated Antibody: A Disintegrin And Metalloprotease 17 (ADAM17) (MBS2056487)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
APC-CY7 Conjugated Antibody: A Disintegrin And Metalloprotease 17 (ADAM17) (MBS2056489)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
Cy3 Conjugated Antibody: A Disintegrin And Metalloprotease 17 (ADAM17) (MBS2056491)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
FITC Conjugated Antibody: A Disintegrin And Metalloprotease 17 (ADAM17) (MBS2056492)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
HRP Conjugated Antibody: A Disintegrin And Metalloprotease 17 (ADAM17) (MBS2056494)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
Biotin Conjugated Secondary Antibody: IgG (MBS2086030)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
FITC Conjugated Secondary Antibody: IgG (MBS2086031)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
Biotin Conjugated Secondary Antibody: IgG (MBS2086033)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
FITC Conjugated Secondary Antibody: IgG (MBS2086034)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 17 Clone #C10 (MBS2025765)
HRP Conjugated Secondary Antibody: IgG (MBS2086035)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2025765 Technical Datasheet    Technical Datasheet PDF
 OMIM    U86755 mRNA
 3D Structure    ModBase 3D Structure for P78536
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 Clonality    Monoclonal
 Isotype    IgG1 Kappa
 Clone Number    C10
 Host    Mouse
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 Purity/Purification    Protein A + Protein G affinity chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Organism Species    Homo sapiens (Human)
 Source    Monoclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant ADAM17 (Lys226~Arg473) expressed in E.coli
 Conjugate    No Conjugate
 Immunogen    Recombinant ADAM17 (Lys226~Arg473) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2056489
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-ADAM17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADAM17 antibody   

WB; IHC; ICC; IP.

 Application Notes for anti-ADAM17 antibody    Western blotting: 0.5-2 ug/mL;1:500-2000
Immunohistochemistry: 5-20 ug/mL;1:50-200
Immunocytochemistry: 5-20 ug/mL;1:50-200
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-ADAM17 antibody    (Figure. Western Blot; Sample: Human U937 Cells.)
anti-ADAM17 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-ADAM17 antibody    (Figure. Western Blot; Sample: Recombinant ADAM17, Human.)
anti-ADAM17 antibody Western Blot (WB) (WB) image
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  Immunohistochemistry(IHC) of anti-ADAM17 antibody    DAB staining on IHC8P; Samples
Human Stomach cancer Tissue
Primary Ab: 20 ug/ml Mouse Anti8
Human ADAM17 Antibody
Second Ab 2 ug/mL HRP8 Linked Caprine
Anti-Mouse IgG Polyclonal Antibody (Catalog: MBS2086035)
anti-ADAM17 antibody 
Immunohistochemistry(IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ADAM17. It may not necessarily be applicable to this product.
 NCBI GI #    73747889
 NCBI GeneID    6868
 NCBI Accession #    NP_003174.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003183.5 [Other Products]
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 UniProt Primary Accession #    P78536 [Other Products]
 UniProt Secondary Accession #    O60226 [Other Products]
 UniProt Related Accession #    P78536 [Other Products]
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 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 17 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 17
 NCBI Official Symbol    ADAM17 [Similar Products]
 NCBI Official Synonym Symbols   
CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 17
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 17
 UniProt Synonym Protein Names   
Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen: CD156b
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAM17 [Similar Products]
 UniProt Synonym Gene Names    CSVP; TACE; ADAM 17 [Similar Products]
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 NCBI Summary for ADAM17    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
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 UniProt Comments for ADAM17    TACE: a type I membrane protein with disintegrin and metalloprotease activity. An ubiquitously expressed ectoenzyme of peptidase family M12B. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Possesses a narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha) to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, and the amyloid precursor protein. Also involved in the activation of Notch pathway. Binds 1 zinc ion per subunit. Two splice variant isoforms have been described.

Protein type: EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 2p25.1

Cellular Component: actin cytoskeleton; apical plasma membrane; cell surface; cytoplasm; cytosol; focal adhesion; integral component of plasma membrane; intercellular junction; membrane; membrane raft; plasma membrane

Molecular Function: integrin binding; interleukin-6 receptor binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; Notch binding; PDZ domain binding; protein binding; SH3 domain binding

Biological Process: B cell differentiation; cell adhesion; cell adhesion mediated by integrin; cell motility; defense response to Gram-positive bacterium; epidermal growth factor receptor signaling pathway; germinal center formation; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway; neutrophil mediated immunity; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cellular component movement; positive regulation of chemokine production; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of leukocyte chemotaxis; positive regulation of protein phosphorylation; positive regulation of T cell chemotaxis; positive regulation of transforming growth factor beta receptor signaling pathway; proteolysis; regulation of mast cell apoptotic process; response to drug; response to high density lipoprotein stimulus; response to hypoxia; response to lipopolysaccharide; spleen development; T cell differentiation in thymus; tumor necrosis factor-mediated signaling pathway; wound healing, spreading of epidermal cells

Disease: Inflammatory Skin And Bowel Disease, Neonatal, 1
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 Research Articles on ADAM17    1. FoxM1 regulates the expression of ADAM-17, which is upregulated in gastric carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAM17 antibodyPathways associated with anti-ADAM17 antibody
 Reference Product  PubMed Publications
 TNF antibody  >112 publications with ADAM17 and TNF
 TIMP3 antibody  >18 publications with ADAM17 and TIMP3
 NOTCH1 antibody  >8 publications with ADAM17 and NOTCH1
 TNFSF11 antibody  >1 publications with ADAM17 and TNFSF11
 TGFA antibody  >1 publications with ADAM17 and TGFA
 DLG1 antibody  >1 publications with ADAM17 and DLG1
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
Diseases associated with anti-ADAM17 antibodyOrgans/Tissues associated with anti-ADAM17 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >383 publications with ADAM17 and Necrosis
 Neoplasms Antibodies  >118 publications with ADAM17 and Neoplasms
 Inflammation Antibodies  >85 publications with ADAM17 and Inflammation
 Nervous System Diseases Antibodies  >43 publications with ADAM17 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >37 publications with ADAM17 and Cardiovascular Diseases
 Liver Diseases Antibodies  >18 publications with ADAM17 and Liver Diseases
 Atherosclerosis Antibodies  >15 publications with ADAM17 and Atherosclerosis
 Lung Diseases Antibodies  >14 publications with ADAM17 and Lung Diseases
 Kidney Diseases Antibodies  >11 publications with ADAM17 and Kidney Diseases
 Liver Neoplasms Antibodies  >11 publications with ADAM17 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >64 publications with ADAM17 and Brain
 Kidney Antibodies  >32 publications with ADAM17 and Kidney
 Muscle Antibodies  >31 publications with ADAM17 and Muscle
 Liver Antibodies  >31 publications with ADAM17 and Liver
 Lung Antibodies  >30 publications with ADAM17 and Lung
 Embryonic Tissue Antibodies  >26 publications with ADAM17 and Embryonic Tissue
 Ovary Antibodies  >15 publications with ADAM17 and Ovary
 Prostate Antibodies  >10 publications with ADAM17 and Prostate
 Eye Antibodies  >10 publications with ADAM17 and Eye
 Bone Marrow Antibodies  >4 publications with ADAM17 and Bone Marrow
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